Aliases for MITD1 Gene
External Ids for MITD1 Gene
Previous GeneCards Identifiers for MITD1 Gene
Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for MITD1 Gene
MITD1 (Microtubule Interacting And Trafficking Domain Containing 1) is a Protein Coding gene. Diseases associated with MITD1 include Lipoyltransferase 1 Deficiency and Omodysplasia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and phosphatidylinositol binding.
UniProtKB/Swiss-Prot Summary for MITD1 Gene
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.