Aliases for MISP Gene
External Ids for MISP Gene
Previous HGNC Symbols for MISP Gene
The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for MISP Gene
MISP (Mitotic Spindle Positioning) is a Protein Coding gene. Diseases associated with MISP include Amyotrophic Lateral Sclerosis Type 22 and N Syndrome. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is MISP3.
UniProtKB/Swiss-Prot Summary for MISP Gene
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.