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Aliases for MIRLET7I Gene

Subcategory (RNA class) for MIRLET7I Gene


Quality Score for this RNA gene is


Aliases for MIRLET7I Gene

  • MicroRNA Let-7i 2 3 5
  • Hsa-Let-7i 3
  • Let-7i 3
  • LET7I 3

External Ids for MIRLET7I Gene

ORGUL Members for MIRLET7I Gene

Previous HGNC Symbols for MIRLET7I Gene


Previous GeneCards Identifiers for MIRLET7I Gene

  • GC12P061286
  • GC12P062997
  • GC12P062604
  • GC12P062605

Summaries for MIRLET7I Gene

Entrez Gene Summary for MIRLET7I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7I Gene

MIRLET7I (MicroRNA Let-7i) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIRLET7I Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7I Gene

Genomics for MIRLET7I Gene

GeneHancer (GH) Regulatory Elements for MIRLET7I Gene

Promoters and enhancers for MIRLET7I Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I062601 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.2 -150 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ENSG00000257354 ENSG00000275180 GC12P062607 LINC01465 MIRLET7I MON2 USP15 FAM19A2
GH12I062784 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +182.8 182762 4.2 USF1 JUN RAD21 RFX5 POLR2A FOS FOSL2 CEBPB USF2 ELF1 LINC01465 MIRLET7I GC12M062761 LOC105369795 PPM1H
GH12I062631 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.2 +28.6 28550 2.2 FOXA2 ARID4B MZF1 DMAP1 ZSCAN9 RAD21 YY1 ZNF335 GLIS2 SCRT2 LINC01465 MIRLET7I MON2 USP15 GC12P062638 ENSG00000275180
GH12I062792 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +190.4 190376 2.1 PKNOX1 SIN3A RAD21 ZBTB40 RFX5 ZNF213 ARID2 ZNF143 RCOR1 ATF7 MIRLET7I LINC01465 GC12M062761 LOC105369795 PPM1H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7I on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7I Gene

Genomic Locations for MIRLET7I Gene
84 bases
Plus strand

Genomic View for MIRLET7I Gene

Genes around MIRLET7I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7I Gene

Proteins for MIRLET7I Gene

Post-translational modifications for MIRLET7I Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7I Gene

Domains & Families for MIRLET7I Gene

Gene Families for MIRLET7I Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7I: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7I Gene

Function for MIRLET7I Gene

Phenotypes From GWAS Catalog for MIRLET7I Gene

Gene Ontology (GO) - Molecular Function for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:0001046 core promoter sequence-specific DNA binding IMP 25336585
genes like me logo Genes that share ontologies with MIRLET7I: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7I Gene

Localization for MIRLET7I Gene

Gene Ontology (GO) - Cellular Components for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIRLET7I: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7I Gene

Pathways & Interactions for MIRLET7I Gene

SuperPathways for MIRLET7I Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIRLET7I: view

Pathways by source for MIRLET7I Gene

1 KEGG pathway for MIRLET7I Gene

Interacting Proteins for MIRLET7I Gene

Gene Ontology (GO) - Biological Process for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA 25336585
GO:0045944 positive regulation of transcription by RNA polymerase II IMP 25336585
genes like me logo Genes that share ontologies with MIRLET7I: view

No data available for SIGNOR curated interactions for MIRLET7I Gene

Drugs & Compounds for MIRLET7I Gene

No Compound Related Data Available

Transcripts for MIRLET7I Gene


(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7I Gene

No ASD Table

Relevant External Links for MIRLET7I Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7I Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7I Gene:

genes like me logo Genes that share expression patterns with MIRLET7I: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7I Gene

Orthologs for MIRLET7I Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7I Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7i 34
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-let-7i 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7i 34
  • 100 (a)
(Mus musculus)
Mammalia Mirlet7i 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
(Gallus gallus)
Aves gga-let-7i 34
  • 87 (a)
(Anolis carolinensis)
Reptilia aca-let-7i 34
  • 100 (a)
(Danio rerio)
Actinopterygii dre-let-7i 34
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7a 34
  • 44 (a)
Species where no ortholog for MIRLET7I was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7I Gene

Gene Tree for MIRLET7I (if available)
Gene Tree for MIRLET7I (if available)

Paralogs for MIRLET7I Gene

No data available for Paralogs for MIRLET7I Gene

Variants for MIRLET7I Gene

Sequence variations from dbSNP and Humsavar for MIRLET7I Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001210968 -- 62,604,071(+) A/C downstream_transcript_variant
rs1003850236 -- 62,602,818(+) C/T upstream_transcript_variant
rs1004323303 -- 62,602,699(+) G/A upstream_transcript_variant
rs1004925218 -- 62,603,452(+) A/G upstream_transcript_variant
rs1005260002 -- 62,603,634(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7I Gene

Variant ID Type Subtype PubMed ID
nsv740 CNV insertion 18451855
nsv821671 CNV loss 15273396

Additional Variant Information for MIRLET7I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7I Gene

Disorders for MIRLET7I Gene

Additional Disease Information for MIRLET7I

No disorders were found for MIRLET7I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7I Gene

Publications for MIRLET7I Gene

  1. Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia. (PMID: 27770612) Xu Y … Wang L (Journal of cellular physiology 2017) 3 58
  2. Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression. (PMID: 28512058) Zhou H … Jia L (Gene 2017) 3 58
  3. Let-7i attenuates human brain microvascular endothelial cell damage in oxygen glucose deprivation model by decreasing toll-like receptor 4 expression. (PMID: 28844675) Xiang W … Deng Z (Biochemical and biophysical research communications 2017) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K … Zhao S (Cancer letters 2016) 3 58

Products for MIRLET7I Gene

Sources for MIRLET7I Gene

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