microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7I Gene

Subcategory (RNA class) for MIRLET7I Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIRLET7I Gene

  • MicroRNA Let-7i 2 3 5
  • Hsa-Let-7i-3p 163 173
  • Hsa-Let-7i-5p 163 173
  • Hsa-Let-7i 2 3
  • MIRLET7I 2 5
  • Hsa-Let-7-P2c2 178
  • MIMAT0004585 50
  • MIMAT0000415 50
  • MIRNLET7I 3
  • MI0000434 50
  • RF00027 168
  • Let-7i 3
  • LET7I 3

External Ids for MIRLET7I Gene

Previous HGNC Symbols for MIRLET7I Gene

  • MIRNLET7I

Previous GeneCards Identifiers for MIRLET7I Gene

  • GC12P061286
  • GC12P062997
  • GC12P062604
  • GC12P062605

Summaries for MIRLET7I Gene

Entrez Gene Summary for MIRLET7I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7I Gene

MIRLET7I (MicroRNA Let-7i) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7I include Ovarian Cancer and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Toll-like Receptor Signaling Pathway and MicroRNAs in cancer.

Rfam classification for MIRLET7I Gene

Additional gene information for MIRLET7I Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7I Gene

Genomics for MIRLET7I Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7I Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J062601 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.2 151 5.1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 ZNF512 LEF1 ENSG00000257354 ENSG00000275180 LINC01465 MIRLET7I MON2 USP15 TAFA2 PPM1H
GH12J062631 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 11.2 +28.6 28551 2.2 RNF2 HNRNPL CTCF PRDM10 TFE3 ZIC2 RBFOX2 RXRB PATZ1 ZNF501 HSALNG0091860 MIRLET7I LINC01465 USP15 piR-52294-036 MON2 PPM1H
GH12J062783 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +183.5 183516 7.2 POLR2A SP1 CEBPB ATF3 NR3C1 USF1 GABPA FOS JUND RFX5 LINC01465 MIRLET7I RF00017-1169 piR-32559-090 PPM1H MON2
GH12J062792 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +189.9 189882 3.1 CEBPG CTCF ZNF143 PKNOX1 REST RAD21 TRIM22 CEBPA ATF7 CEBPB LINC01465 MIRLET7I RF00017-1169 piR-32559-090 PPM1H MON2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7I on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7I Gene

Genomic Locations for MIRLET7I Gene
chr12:62,603,685-62,603,771
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr12:62,997,466-62,997,550
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIRLET7I Gene

Genes around MIRLET7I on UCSC Golden Path with GeneCards custom track
MIRLET7I in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7I Gene

Proteins for MIRLET7I Gene

Post-translational modifications for MIRLET7I Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7I Gene

Domains & Families for MIRLET7I Gene

Gene Families for MIRLET7I Gene

genes like me logo Genes that share domains with MIRLET7I: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7I Gene

Function for MIRLET7I Gene

Phenotypes From GWAS Catalog for MIRLET7I Gene

Gene Ontology (GO) - Molecular Function for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:0001046 core promoter sequence-specific DNA binding IMP 25336585
GO:0003730 mRNA 3'-UTR binding IDA 17660297
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17660297
genes like me logo Genes that share ontologies with MIRLET7I: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7I Gene

Localization for MIRLET7I Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7I gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIRLET7I: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7I Gene

Pathways & Interactions for MIRLET7I Gene

genes like me logo Genes that share pathways with MIRLET7I: view

Pathways by source for MIRLET7I Gene

1 BioSystems pathway for MIRLET7I Gene
1 KEGG pathway for MIRLET7I Gene

Gene Ontology (GO) - Biological Process for MIRLET7I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 28844675
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 17660297
GO:0042832 defense response to protozoan IMP 17660297
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA 25336585
genes like me logo Genes that share ontologies with MIRLET7I: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7I Gene

Drugs & Compounds for MIRLET7I Gene

No Compound Related Data Available

Transcripts for MIRLET7I Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7I Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004023EA_9606 miRNA 22 6

RefSeq: NR_029661,

LncBase: hsa-let-7i-5p,

miRBase: MIMAT0000415,

MirGeneDB: Hsa-Let-7-P2c2_5p,

TarBase: hsa-let-7i-5p,

ENA: HB859641.1:1..22:misc_RNA, LM379033.1:1..22:ncRNA, LM608476.1:6..27:ncRNA,

URS000075B982_9606 precursor_RNA 84 5

HGNC: 31486,

RefSeq: NR_029661,

Ensembl: ENST00000362309 (view in UCSC) ,

miRBase: MI0000434,

ENA: LM608476.1:1..84:precursor_RNA,

URS0000237CBD_9606 miRNA 22 5

RefSeq: NR_029661,

LncBase: hsa-let-7i-3p,

miRBase: MIMAT0004585,

TarBase: hsa-let-7i-3p,

ENA: LM380263.1:1..22:ncRNA, LM608476.1:62..83:ncRNA,

URS0000052456_9606 precursor_RNA 87 1

Rfam: RF00027,

URS0000EFEAAC_9606 precursor_RNA 78 1

MirGeneDB: Hsa-Let-7-P2c2,

MIRLET7I in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7I Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7I Gene

No ASD Table

Relevant External Links for MIRLET7I Gene

GeneLoc Exon Structure for
MIRLET7I

Expression for MIRLET7I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7I Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7I

Evidence on tissue expression from TISSUES for MIRLET7I Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with MIRLET7I: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7I Gene

Orthologs for MIRLET7I Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7I Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-let-7i 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7i 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7i 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mirlet7i 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 40 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 33 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-let-7i 31
  • 87 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7i 31
  • 100 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7i 31
  • 77 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-let-7a 31
  • 44 (a)
ManyToMany
Species where no ortholog for MIRLET7I was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7I Gene

ENSEMBL:
Gene Tree for MIRLET7I (if available)
TreeFam:
Gene Tree for MIRLET7I (if available)

Paralogs for MIRLET7I Gene

No data available for Paralogs for MIRLET7I Gene

Variants for MIRLET7I Gene

Additional dbSNP identifiers (rs#s) for MIRLET7I Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7I Gene

Variant ID Type Subtype PubMed ID
nsv740 CNV insertion 18451855
nsv821671 CNV loss 15273396

Additional Variant Information for MIRLET7I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7I Gene

Disorders for MIRLET7I Gene

MalaCards: The human disease database

(27) MalaCards diseases for MIRLET7I Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
squamous cell carcinoma, head and neck
  • hnscc
alzheimer disease
  • ad
fatal familial insomnia
  • ffi
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7I

genes like me logo Genes that share disorders with MIRLET7I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7I Gene

Publications for MIRLET7I Gene

  1. Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients naïve to anti-TNF therapy. (PMID: 30911942) Reyes-Loyola P … Amezcua-Guerra LM (Clinical rheumatology 2019) 3
  2. Circulating MicroRNAs as Novel Potential Biomarkers for Left Ventricular Remodeling in Postinfarction Heart Failure. (PMID: 31885737) Gao G … Yang P (Disease markers 2019) 3
  3. [Let-7i reduces chemotherapy resistance in breast cancer cells through down-regulation of K-Ras and Bcl2 expression]. (PMID: 31878995) Qin M … Liu X (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2019) 3
  4. Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1. (PMID: 29858755) Shi Y … Li F (Protein & cell 2019) 3
  5. Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6. (PMID: 30015976) Song J … He N (Oncology reports 2018) 3

Products for MIRLET7I Gene

Sources for MIRLET7I Gene