Aliases for MIRLET7G Gene
Subcategory (RNA class) for MIRLET7G Gene
miRNA
Quality Score for this RNA gene is
10.2
External Ids for MIRLET7G Gene
- HGNC: 31485
- Entrez Gene: 406890
- Ensembl: ENSG00000199150
- OMIM: 612102
- miRBase: hsa-let-7g
ORGUL Members for MIRLET7G Gene
Previous HGNC Symbols for MIRLET7G Gene
- MIRNLET7G
Previous GeneCards Identifiers for MIRLET7G Gene
- GC03M052280
- GC03M052302
Summaries for MIRLET7G Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIRLET7G Gene
MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.
fRNAdb sequence ontologies for MIRLET7G Gene - the ORGUL cluster for this gene includes several descriptions:
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIRLET7G Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene
Genomics for MIRLET7G Gene
GeneHancer (GH) Regulatory Elements for MIRLET7G Gene
Promoters and enhancers for MIRLET7G Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I052269 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 0.8 | -3.2 | -3195 | 4.9 | ZNF121 KLF1 PRDM10 ZBTB33 PRDM1 | ITIH4 GLYCTK PPM1M MUSTN1 GC03M052275 MIRLET7G WDR82 | |
| GH03I052265 | Enhancer | 0.7 | ENCODE dbSUPER | 0.8 | +2.8 | 2801 | 0.2 | CTCF CTBP1 DPF2 MNT ZBTB33 NR2F2 | TWF2 MIRLET7G PIR44903 WDR82 | |
| GH03I052264 | Enhancer | 0.3 | dbSUPER | 0.8 | +3.4 | 3409 | 0.5 | NR2F2 | PPM1M MIRLET7G PIR44903 WDR82 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIRLET7G on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIRLET7G Gene
Genomic Locations for MIRLET7G Gene
- chr3:52,268,278-52,268,361
- (GRCh38/hg38)
- Size:
- 84 bases
- Orientation:
- Minus strand
- chr3:52,302,292-52,302,379
- (GRCh37/hg19)
Genomic View for MIRLET7G Gene
Genes around MIRLET7G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.2 by Ensembl
- 3p21.2 by Entrez Gene
- 3p21.2 by HGNC
MIRLET7G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIRLET7G Gene
ORGUL Member Location for MIRLET7G Gene
Proteins for MIRLET7G Gene
Post-translational modifications for MIRLET7G Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIRLET7G
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7G
- Origene Custom Protein Services for MIRLET7G
- Search GeneTex for Proteins for MIRLET7G
No data available for DME Specific Peptides for MIRLET7G Gene
Domains & Families for MIRLET7G Gene
Gene Families for MIRLET7G Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7G Gene
Function for MIRLET7G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 24291274 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIRLET7G
-
-
ViGene Biosciences pre-made micro RNAs for MIRLET7G gene
- Search ViGene Biosciences for MIRLET7G
CRISPR Products
- Browse CRISPR knockouts for MIRLET7G
- Applied Biological Materials CRISPR for MIRLET7G
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
-
ViGene Biosciences pre-made micro RNAs for MIRLET7G gene
Inhibitory RNA Products
- Search ViGene Biosciences for MIRLET7G
Clone Products
- GenScript: Custom all cDNA clones Services for MIRLET7G
- VectorBuilder custom plasmid, inducible vectors for MIRLET7G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIRLET7G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIRLET7G
- Applied Biological Materials Clones for MIRLET7G
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7G Gene
Localization for MIRLET7G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7G Gene
Pathways & Interactions for MIRLET7G Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
| 3 | Parkinsons Disease Pathway | ||
Pathways by source for MIRLET7G Gene
2 BioSystems pathways for MIRLET7G Gene
1 KEGG pathway for MIRLET7G Gene
Interacting Proteins for MIRLET7G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IDA | 24291274 |
| GO:0035195 | gene silencing by miRNA | IDA | 24291274 |
| GO:0045766 | positive regulation of angiogenesis | IDA | 24291274 |
| GO:0050728 | negative regulation of inflammatory response | IDA | 24291274 |
| GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation | IDA | 24291274 |
No data available for SIGNOR curated interactions for MIRLET7G Gene
Transcripts for MIRLET7G Gene
fRNAdb Secondary structures for MIRLET7G Gene
mRNA/cDNA for MIRLET7G Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIRLET7G
- Applied Biological Materials CRISPR for MIRLET7G
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
-
ViGene Biosciences pre-made micro RNAs for MIRLET7G gene
Inhibitory RNA Products
- Search ViGene Biosciences for MIRLET7G
Clone Products
- GenScript: Custom all cDNA clones Services for MIRLET7G
- VectorBuilder custom plasmid, inducible vectors for MIRLET7G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIRLET7G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIRLET7G
- Applied Biological Materials Clones for MIRLET7G
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIRLET7G Gene
NURSA nuclear receptor signaling pathways regulating expression of MIRLET7G Gene:
MIRLET7GPrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7G Gene
Orthologs for MIRLET7G Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | bta-let-7g 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-let-7g 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7g 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mirlet7g 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7g 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-let-7g 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-let-7g 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-let-7g 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-let-7j 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | csa-let-7d 34 |
|
ManyToMany |
- Species where no ortholog for MIRLET7G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIRLET7G Gene
No data available for Paralogs for MIRLET7G Gene
Variants for MIRLET7G Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000388354 | -- | 52,268,659(-) | T/C | upstream_transcript_variant | |
| rs1001687191 | -- | 52,269,707(-) | G/T | upstream_transcript_variant | |
| rs1002563543 | -- | 52,268,906(-) | C/T | upstream_transcript_variant | |
| rs1002926130 | -- | 52,269,158(-) | A/C | upstream_transcript_variant | |
| rs1003624331 | -- | 52,269,925(-) | A/G | upstream_transcript_variant |
Additional Variant Information for MIRLET7G Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIRLET7G
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7G Gene
Disorders for MIRLET7G Gene
Additional Disease Information for MIRLET7G
No disorders were found for MIRLET7G Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7G Gene
Publications for MIRLET7G Gene
- Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
- Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
- Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
- MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication. (PMID: 26489607) Chou WW … Dai CY (Journal of molecular medicine (Berlin, Germany) 2016) 3 58
- BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K … Zhao S (Cancer letters 2016) 3 58
Products for MIRLET7G Gene
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- Browse R&D Systems for biochemical assays
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- Browse Cell Selection and Detection Kits
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIRLET7G
- VectorBuilder custom plasmid, inducible vectors for MIRLET7G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIRLET7G
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MIRLET7G
- Search GeneTex for Antibodies for MIRLET7G
- Search GeneTex for Proteins for MIRLET7G
- ViGene Biosciences pre-made micro RNAs for MIRLET7G gene
- Search ViGene Biosciences for MIRLET7G
Sources for MIRLET7G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
