microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7G Gene

Data sources for MIRLET7G Gene:

RNA type for MIRLET7G Gene

miRNA

Aliases for MIRLET7G Gene

External Ids for MIRLET7G Gene

Previous HGNC Symbols for MIRLET7G Gene

  • MIRNLET7G

Previous GeneCards Identifiers for MIRLET7G Gene

  • GC03M052280
  • GC03M052302

Summaries for MIRLET7G Gene

Entrez Gene Summary for MIRLET7G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7G Gene

MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7G include Ovarian Cancer and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

Rfam classification for MIRLET7G Gene

Additional gene information for MIRLET7G Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene

Genomics for MIRLET7G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J052258 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +6.2 6199 7.7 CTBP1 ZNF316 ZBTB48 CTCF ZNF384 MAFG ZBTB33 DPF2 MAFK MNT piR-50904 GLYCTK PPM1M TWF2 WDR82 MIR135A1 GLYCTK-AS1 LOC101929054 ENSG00000173366 TLR9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7G on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7G Gene

Latest Assembly
chr3:52,268,276-52,268,363
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand

Previous Assembly
chr3:52,302,294-52,302,377
(GRCh37/hg19 by Entrez Gene)
Size:
84 bases
Orientation:
Minus strand

chr3:52,302,292-52,302,379
(GRCh37/hg19 by Ensembl)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIRLET7G Gene

Genes around MIRLET7G on UCSC Golden Path with GeneCards custom track
MIRLET7G in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7G Gene

Proteins for MIRLET7G Gene

Post-translational modifications for MIRLET7G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7G Gene

Domains & Families for MIRLET7G Gene

Gene Families for MIRLET7G Gene

genes like me logo Genes that share domains with MIRLET7G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7G Gene

Function for MIRLET7G Gene

Phenotypes From GWAS Catalog for MIRLET7G Gene

Gene Ontology (GO) - Molecular Function for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20338660
genes like me logo Genes that share ontologies with MIRLET7G: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7G Gene

Localization for MIRLET7G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7G gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7G Gene

Pathways & Interactions for MIRLET7G Gene

genes like me logo Genes that share pathways with MIRLET7G: view

Pathways by source for MIRLET7G Gene

2 BioSystems pathways for MIRLET7G Gene
1 KEGG pathway for MIRLET7G Gene

Gene Ontology (GO) - Biological Process for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IDA 20338660
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 24291274
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045766 positive regulation of angiogenesis IDA 24291274
GO:0050728 negative regulation of inflammatory response IDA 24291274
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7G Gene

Drugs & Compounds for MIRLET7G Gene

No Compound Related Data Available

Transcripts for MIRLET7G Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7G Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004AFF8D_9606 miRNA 22 6

RefSeq: NR_029660,

LncBase: hsa-let-7g-5p,

miRBase: MIMAT0000414,

MirGeneDB: Hsa-Let-7-P2c3_5p,

TarBase: hsa-let-7g-5p,

ENA: HB859640.1:1..22:misc_RNA, LM379032.1:1..22:ncRNA, LM608475.1:5..26:ncRNA,

URS000029979D_9606 miRNA 21 6

RefSeq: NR_029660,

LncBase: hsa-let-7g-3p,

miRBase: MIMAT0004584,

MirGeneDB: Hsa-Let-7-P2c3_3p,

TarBase: hsa-let-7g-3p,

ENA: LM380262.1:1..21:ncRNA, LM608475.1:62..82:ncRNA,

URS00003DBD40_9606 pre_miRNA 84 4

RefSeq: NR_029660,

Ensembl: ENST00000362280 (view in UCSC) ,

miRBase: MI0000433,

ENA: LM608475.1:1..84:precursor_RNA,

URS00000B0351_9606 pre_miRNA 88 1

Rfam: RF00027,

URS0001BC1704_9606 pre_miRNA 88 1

Rfam: RF00027,

MIRLET7G in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7G Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7G Gene

No ASD Table

Relevant External Links for MIRLET7G Gene

GeneLoc Exon Structure for
MIRLET7G

Expression for MIRLET7G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7G

genes like me logo Genes that share expression patterns with MIRLET7G: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7G Gene

Orthologs for MIRLET7G Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7G Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-let-7g 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7g 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mirlet7g 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7g 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7g 30
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7g 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7g 30
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7g 30
  • 96 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7j 30
  • 72 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-let-7d 30
  • 42 (a)
ManyToMany
Species where no ortholog for MIRLET7G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7G Gene

ENSEMBL:
Gene Tree for MIRLET7G (if available)
TreeFam:
Gene Tree for MIRLET7G (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7G

Paralogs for MIRLET7G Gene

No data available for Paralogs for MIRLET7G Gene

Variants for MIRLET7G Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7G Gene

Variant ID Type Subtype PubMed ID
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv822090 CNV gain 20364138
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897

Additional Variant Information for MIRLET7G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7G
Leiden Open Variation Database (LOVD)
MIRLET7G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7G Gene

Disorders for MIRLET7G Gene

MalaCards: The human disease database

(29) MalaCards diseases for MIRLET7G Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • lung cancer, susceptibility to
squamous cell carcinoma, head and neck
  • hnscc
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7G

genes like me logo Genes that share disorders with MIRLET7G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7G Gene

Publications for MIRLET7G Gene

  1. Long Noncoding RNA Hypoxia-Inducible Factor-1 Alpha-Antisense RNA 1 Regulates Vascular Smooth Muscle Cells to Promote the Development of Thoracic Aortic Aneurysm by Modulating Apoptotic Protease-Activating Factor 1 and Targeting let-7g. (PMID: 32653692) Zhang X … Li B (The Journal of surgical research 2020) 3
  2. The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1. (PMID: 32102121) Cui F … Ma S (Yonsei medical journal 2020) 3
  3. Circulating let-7g-5p and miR-191-5p Are Independent Predictors of Chronic Kidney Disease in Hypertensive Patients. (PMID: 32115655) Berillo O … Schiffrin EL (American journal of hypertension 2020) 3
  4. MicroRNA let-7g-5p alleviates murine collagen-induced arthritis by inhibiting Th17 cell differentiation. (PMID: 31987855) Yang P … Zhou L (Biochemical pharmacology 2020) 3
  5. Evaluating prognostic utility of preoperative Neutrophil to Lymphocyte Ratio and hsa-let-7g/c up-regulation in patients with urinary bladder cancer. (PMID: 31683460) Boubaker NS … Ouerhani S (Cancer biomarkers : section A of Disease markers 2020) 3

Products for MIRLET7G Gene

Sources for MIRLET7G Gene