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Aliases for MIRLET7G Gene

Subcategory (RNA class) for MIRLET7G Gene


Quality Score for this RNA gene is


Aliases for MIRLET7G Gene

  • MicroRNA Let-7g 2 3 5
  • Hsa-Let-7g 3
  • Let-7g 3
  • LET7G 3

External Ids for MIRLET7G Gene

Previous HGNC Symbols for MIRLET7G Gene


Previous GeneCards Identifiers for MIRLET7G Gene

  • GC03M052280
  • GC03M052302

Summaries for MIRLET7G Gene

Entrez Gene Summary for MIRLET7G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7G Gene

MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIRLET7G Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7G

Additional gene information for MIRLET7G Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7G Gene

Genomics for MIRLET7G Gene

GeneHancer (GH) Regulatory Elements for MIRLET7G Gene

Promoters and enhancers for MIRLET7G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052269 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.8 -3.2 -3195 4.9 ZNF121 KLF1 PRDM10 ZBTB33 PRDM1 ITIH4 GLYCTK PPM1M MUSTN1 GC03M052275 MIRLET7G WDR82
GH03I052265 Enhancer 0.7 ENCODE dbSUPER 0.8 +2.8 2801 0.2 CTCF CTBP1 DPF2 MNT ZBTB33 NR2F2 TWF2 MIRLET7G PIR44903 WDR82
GH03I052264 Enhancer 0.3 dbSUPER 0.8 +3.4 3409 0.5 NR2F2 PPM1M MIRLET7G PIR44903 WDR82
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7G on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7G Gene

Genomic Locations for MIRLET7G Gene
84 bases
Minus strand

Genomic View for MIRLET7G Gene

Genes around MIRLET7G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7G Gene

ORGUL Member Location for MIRLET7G Gene

ORGUL Member Location for MIRLET7G gene

Proteins for MIRLET7G Gene

Post-translational modifications for MIRLET7G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7G Gene

Domains & Families for MIRLET7G Gene

Gene Families for MIRLET7G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7G Gene

Function for MIRLET7G Gene

Gene Ontology (GO) - Molecular Function for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24291274
genes like me logo Genes that share ontologies with MIRLET7G: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7G Gene

Localization for MIRLET7G Gene

Gene Ontology (GO) - Cellular Components for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7G Gene

Pathways & Interactions for MIRLET7G Gene

genes like me logo Genes that share pathways with MIRLET7G: view

Pathways by source for MIRLET7G Gene

2 BioSystems pathways for MIRLET7G Gene
1 KEGG pathway for MIRLET7G Gene

Interacting Proteins for MIRLET7G Gene

Gene Ontology (GO) - Biological Process for MIRLET7G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 24291274
GO:0035195 gene silencing by miRNA IDA 24291274
GO:0045766 positive regulation of angiogenesis IDA 24291274
GO:0050728 negative regulation of inflammatory response IDA 24291274
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IDA 24291274
genes like me logo Genes that share ontologies with MIRLET7G: view

No data available for SIGNOR curated interactions for MIRLET7G Gene

Drugs & Compounds for MIRLET7G Gene

No Compound Related Data Available

Transcripts for MIRLET7G Gene

fRNAdb Secondary structures for MIRLET7G Gene

  • FR046598


(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7G Gene

No ASD Table

Relevant External Links for MIRLET7G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIRLET7G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7G Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7G Gene:

genes like me logo Genes that share expression patterns with MIRLET7G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7G Gene

Orthologs for MIRLET7G Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-let-7g 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-let-7g 34
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-let-7g 34
  • 100 (a)
(Mus musculus)
Mammalia Mirlet7g 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-let-7g 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-let-7g 34
  • 88 (a)
(Gallus gallus)
Aves gga-let-7g 34
  • 95 (a)
(Anolis carolinensis)
Reptilia aca-let-7g 34
  • 96 (a)
(Danio rerio)
Actinopterygii dre-let-7j 34
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7d 34
  • 42 (a)
Species where no ortholog for MIRLET7G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7G Gene

Gene Tree for MIRLET7G (if available)
Gene Tree for MIRLET7G (if available)

Paralogs for MIRLET7G Gene

No data available for Paralogs for MIRLET7G Gene

Variants for MIRLET7G Gene

Sequence variations from dbSNP and Humsavar for MIRLET7G Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000388354 -- 52,268,659(-) T/C upstream_transcript_variant
rs1001687191 -- 52,269,707(-) G/T upstream_transcript_variant
rs1002563543 -- 52,268,906(-) C/T upstream_transcript_variant
rs1002926130 -- 52,269,158(-) A/C upstream_transcript_variant
rs1003624331 -- 52,269,925(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7G Gene

Variant ID Type Subtype PubMed ID
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv822090 CNV gain 20364138
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897

Additional Variant Information for MIRLET7G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7G Gene

Disorders for MIRLET7G Gene

Additional Disease Information for MIRLET7G

No disorders were found for MIRLET7G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7G Gene

Publications for MIRLET7G Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
  2. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication. (PMID: 26489607) Chou WW … Dai CY (Journal of molecular medicine (Berlin, Germany) 2016) 3 58
  5. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. (PMID: 26655271) Wu K … Zhao S (Cancer letters 2016) 3 58

Products for MIRLET7G Gene

Sources for MIRLET7G Gene

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