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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIRLET7G (MicroRNA Let-7g) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7G include Ovarian Cancer and Lung Cancer. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03J052269 | Promoter/Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.7 | -2.9 | -2928 | 4.4 | PRDM10 PRDM1 RBFOX2 NR2F2 ZNF660 ZBTB33 KLF1 BHLHE40 ZNF121 | ITIH4 GLYCTK PPM1M MUSTN1 MIRLET7G lnc-TWF2-1 WDR82 | |
GH03J052265 | Enhancer | 0.7 | ENCODE dbSUPER | 0.7 | +2.8 | 2803 | 0.2 | ZBTB33 CTBP1 CTCF NR2F2 DPF2 ZNF384 MNT | TWF2 MIRLET7G piR-50904 PPM1M WDR82 GLYCTK | |
GH03J052264 | Enhancer | 0.3 | dbSUPER | 0.7 | +3.4 | 3411 | 0.5 | NR2F2 | PPM1M MIRLET7G piR-50904 WDR82 GLYCTK |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20338660 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0005623 | cell | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Metastatic brain tumor | ||
3 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030336 | negative regulation of cell migration | IDA | 20338660 |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IDA | 24291274 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045766 | positive regulation of angiogenesis | IDA | 24291274 |
GO:0050728 | negative regulation of inflammatory response | IDA | 24291274 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00004AFF8D_9606 | miRNA | 22 | 6 |
RefSeq: NR_029660, LncBase: hsa-let-7g-5p, miRBase: MIMAT0000414, MirGeneDB: Hsa-Let-7-P2c3_5p, TarBase: hsa-let-7g-5p, ENA: HB859640.1:1..22:misc_RNA, LM379032.1:1..22:ncRNA, LM608475.1:5..26:ncRNA, |
URS000029979D_9606 | miRNA | 21 | 6 |
RefSeq: NR_029660, LncBase: hsa-let-7g-3p, miRBase: MIMAT0004584, MirGeneDB: Hsa-Let-7-P2c3_3p, TarBase: hsa-let-7g-3p, |
URS00003DBD40_9606 | precursor_RNA | 84 | 5 |
HGNC: 31485, RefSeq: NR_029660, Ensembl: ENST00000362280 (view in UCSC) , miRBase: MI0000433, |
URS00000B0351_9606 | precursor_RNA | 88 | 1 |
Rfam: RF00027, |
URS0000EFBC1D_9606 | precursor_RNA | 79 | 1 |
MirGeneDB: Hsa-Let-7-P2c3, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-let-7g 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7g 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mirlet7g 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-let-7g 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7g 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-let-7g 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-let-7g 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-let-7g 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-let-7j 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-let-7d 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|
|
lung cancer |
|
|
clear cell renal cell carcinoma |
|
|
squamous cell carcinoma, head and neck |
|
|
oral squamous cell carcinoma |
|