microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7F2 Gene

Subcategory (RNA class) for MIRLET7F2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIRLET7F2 Gene

  • MicroRNA Let-7f-2 2 3 5
  • Hsa-Let-7f-2-3p 163 173
  • Hsa-Let-7f-5p 163 173
  • Hsa-Let-7f-2 2 3
  • MIRLET7F2 2 5
  • Hsa-Let-7-P2a3 178
  • MIMAT0000067 50
  • MIMAT0004487 50
  • MIRNLET7F2 3
  • MI0000068 50
  • Let-7f-2 3
  • RF00027 168
  • LET7F2 3

External Ids for MIRLET7F2 Gene

Previous HGNC Symbols for MIRLET7F2 Gene

  • MIRNLET7F2

Previous GeneCards Identifiers for MIRLET7F2 Gene

  • GC0XM053602
  • GC0XM053558
  • GC0XM053574

Summaries for MIRLET7F2 Gene

Entrez Gene Summary for MIRLET7F2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F2 Gene

MIRLET7F2 (MicroRNA Let-7f-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7F2 include Kidney Cancer and Breast Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7F2 Gene

Additional gene information for MIRLET7F2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7F2 Gene

Genomics for MIRLET7F2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7F2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ053635 Enhancer 0.2 Ensembl 13.4 -78.4 -78427 0.2 HUWE1 MIR98 MIRLET7F2 lnc-HSD17B10-7 piR-50443-404 RF00017-8455 RF00017-8454 HSD17B10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7F2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7F2 Gene

Genomic Locations for MIRLET7F2 Gene
chrX:53,557,192-53,557,274
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chrX:53,584,153-53,584,235
(GRCh37/hg19)
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIRLET7F2 Gene

Genes around MIRLET7F2 on UCSC Golden Path with GeneCards custom track
MIRLET7F2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F2 Gene

Proteins for MIRLET7F2 Gene

Post-translational modifications for MIRLET7F2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F2 Gene

Domains & Families for MIRLET7F2 Gene

Gene Families for MIRLET7F2 Gene

genes like me logo Genes that share domains with MIRLET7F2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7F2 Gene

Function for MIRLET7F2 Gene

Phenotypes From GWAS Catalog for MIRLET7F2 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21508257
genes like me logo Genes that share ontologies with MIRLET7F2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7F2 Gene

Localization for MIRLET7F2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7F2 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIRLET7F2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7F2 Gene

Pathways & Interactions for MIRLET7F2 Gene

PathCards logo

SuperPathways for MIRLET7F2 Gene

genes like me logo Genes that share pathways with MIRLET7F2: view

Pathways by source for MIRLET7F2 Gene

1 BioSystems pathway for MIRLET7F2 Gene
1 KEGG pathway for MIRLET7F2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 28345812
GO:0032007 negative regulation of TOR signaling IDA 21962509
GO:0032700 negative regulation of interleukin-17 production IDA 21508257
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043066 negative regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with MIRLET7F2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7F2 Gene

Drugs & Compounds for MIRLET7F2 Gene

No Compound Related Data Available

Transcripts for MIRLET7F2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7F2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003B7674_9606 miRNA 22 6

RefSeq: NR_029483, NR_029484,

LncBase: hsa-let-7f-5p,

miRBase: MIMAT0000067,

MirGeneDB: Hsa-Let-7-P2a3_5p, Hsa-Let-7-P2b1_5p,

TarBase: hsa-let-7f-5p,

ENA: View 6 records in RNAcentral

URS000075D19A_9606 precursor_RNA 83 5

HGNC: 31484,

RefSeq: NR_029484,

Ensembl: ENST00000385277 (view in UCSC) ,

miRBase: MI0000068,

ENA: LM608157.1:1..83:precursor_RNA,

URS00001C04A2_9606 miRNA 22 5

RefSeq: NR_029484,

LncBase: hsa-let-7f-2-3p,

miRBase: MIMAT0004487,

TarBase: hsa-let-7f-2-3p,

ENA: LM380167.1:1..22:ncRNA, LM608157.1:58..79:ncRNA,

URS00005D05D7_9606 precursor_RNA 81 1

Rfam: RF00027,

URS0000EFE6B5_9606 precursor_RNA 72 1

MirGeneDB: Hsa-Let-7-P2a3,

MIRLET7F2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7F2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F2 Gene

No ASD Table

Relevant External Links for MIRLET7F2 Gene

GeneLoc Exon Structure for
MIRLET7F2

Expression for MIRLET7F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7F2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7F2

genes like me logo Genes that share expression patterns with MIRLET7F2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7F2 Gene

Orthologs for MIRLET7F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7F2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7f-2 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7f-2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mirlet7f-2 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7f-2 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-2 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7a-1 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7f-1 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-1 31
  • 76 (a)
OneToOne
Species where no ortholog for MIRLET7F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7F2 Gene

ENSEMBL:
Gene Tree for MIRLET7F2 (if available)
TreeFam:
Gene Tree for MIRLET7F2 (if available)

Paralogs for MIRLET7F2 Gene

No data available for Paralogs for MIRLET7F2 Gene

Variants for MIRLET7F2 Gene

Additional dbSNP identifiers (rs#s) for MIRLET7F2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F2 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv3576879 CNV gain 25503493
nsv435891 CNV deletion 17901297

Additional Variant Information for MIRLET7F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7F2 Gene

Disorders for MIRLET7F2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIRLET7F2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
kidney cancer
  • renal cell carcinoma
breast cancer
  • breast lobular carcinoma
hepatocellular carcinoma
  • hcc
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7F2

genes like me logo Genes that share disorders with MIRLET7F2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7F2 Gene

Publications for MIRLET7F2 Gene

  1. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3
  2. Reduced expression of let-7f activates TGF-β/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure. (PMID: 28345812) Dhahri W … Rivard A (Journal of cellular and molecular medicine 2017) 3
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  4. Initial research on the relationship between let-7 family members in the serum and massive cerebral infarction. (PMID: 26810534) Gong Z … Jia Y (Journal of the neurological sciences 2016) 3
  5. Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. (PMID: 26178671) Yan YX … He Y (Endocrine journal 2015) 3

Products for MIRLET7F2 Gene

Sources for MIRLET7F2 Gene