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Aliases for MIRLET7F1 Gene

Subcategory (RNA class) for MIRLET7F1 Gene

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Quality Score for this RNA gene is

13

Aliases for MIRLET7F1 Gene

  • MicroRNA Let-7f-1 2 3 5
  • Hsa-Let-7f-1 3
  • MIRNLET7F1 3
  • Let-7f-1 3
  • LET7F1 3

External Ids for MIRLET7F1 Gene

ORGUL Members for MIRLET7F1 Gene

Previous HGNC Symbols for MIRLET7F1 Gene

  • MIRNLET7F1

Previous GeneCards Identifiers for MIRLET7F1 Gene

  • GC09P095983
  • GC09P096939
  • GC09P096943
  • GC09P096945
  • GC09P096951
  • GC09P096956
  • GC09P094177
  • GC09P094179
  • GC09P094180
  • GC09P094181
  • GC09P094182
  • GC09P094184
  • GC09P094186
  • GC09P094189

Summaries for MIRLET7F1 Gene

Entrez Gene Summary for MIRLET7F1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F1 Gene

MIRLET7F1 (MicroRNA Let-7f-1) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIRLET7F1 include Pituitary Adenoma and Pancreatic Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIRLET7F1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7F1 Gene

Genomics for MIRLET7F1 Gene

GeneHancer (GH) Regulatory Elements for MIRLET7F1 Gene

Promoters and enhancers for MIRLET7F1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J094175 Enhancer 0.5 ENCODE 650.7 -0.6 -587 1.2 POLR2A RBM22 RUNX3 SUPT5H SPI1 ENSG00000269929 GC09P094193 GC09P094199 GC09P094201 GC09P094206 GC09P094207 MIRLET7A1 MIRLET7F1 PIR33013 PIR42143
GH09J094083 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 9.8 -91.4 -91383 2.1 MXI1 GTF2E2 MAX BMI1 ZIC2 ZNF644 ZFHX2 CTBP1 MTA3 POLR2A PTPDC1 MIRLET7D MIRLET7A1 MIRLET7F1 CYCSP24 ENSG00000269946
GH09J094212 Enhancer 0.8 ENCODE 11.3 +36.3 36323 0.9 HDAC1 ATF1 CHAMP1 TCF12 ZNF766 GATA2 ATF7 CREM NCOA1 REST MIRLET7D MIRLET7A1 MIRLET7F1 ENSG00000269946 LOC100132077 MIRLET7DHG PIR33030
GH09J094065 Enhancer 0.8 Ensembl ENCODE 11.2 -110.6 -110646 0.6 CTCF IRF2 ZNF654 ARNT TRIM22 REST RAD21 CC2D1A MEF2D ARID2 MIRLET7A1 MIRLET7D MIRLET7F1 CYCSP24 PTPDC1 ENSG00000269946
GH09J094110 Enhancer 0.8 ENCODE 10.7 -65.3 -65297 1 HDAC1 ATF1 PKNOX1 TAF9B ARNT NCOA2 TCF12 GATA2 ATF7 CEBPB MIRLET7A1 MIRLET7D MIRLET7F1 BARX1-DT ENSG00000269946 CYCSP24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7F1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7F1 Gene

Genomic Locations for MIRLET7F1 Gene
chr9:94,176,347-94,176,433
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr9:96,938,629-96,938,715
(GRCh37/hg19)

Genomic View for MIRLET7F1 Gene

Genes around MIRLET7F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F1 Gene

Proteins for MIRLET7F1 Gene

Post-translational modifications for MIRLET7F1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F1 Gene

Domains & Families for MIRLET7F1 Gene

Gene Families for MIRLET7F1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7F1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7F1 Gene

Function for MIRLET7F1 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21962509
genes like me logo Genes that share ontologies with MIRLET7F1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7F1 Gene

Localization for MIRLET7F1 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIRLET7F1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7F1 Gene

Pathways & Interactions for MIRLET7F1 Gene

genes like me logo Genes that share pathways with MIRLET7F1: view

Pathways by source for MIRLET7F1 Gene

2 BioSystems pathways for MIRLET7F1 Gene
1 KEGG pathway for MIRLET7F1 Gene

Interacting Proteins for MIRLET7F1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 28345812
GO:0032007 negative regulation of TOR signaling IDA 21962509
GO:0035195 gene silencing by miRNA IDA 21962509
GO:0051898 negative regulation of protein kinase B signaling IDA 21962509
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA 28345812
genes like me logo Genes that share ontologies with MIRLET7F1: view

No data available for SIGNOR curated interactions for MIRLET7F1 Gene

Drugs & Compounds for MIRLET7F1 Gene

No Compound Related Data Available

Transcripts for MIRLET7F1 Gene

mRNA/cDNA for MIRLET7F1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F1 Gene

No ASD Table

Relevant External Links for MIRLET7F1 Gene

GeneLoc Exon Structure for
MIRLET7F1
ECgene alternative splicing isoforms for
MIRLET7F1

Expression for MIRLET7F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7F1 Gene:

MIRLET7F1
genes like me logo Genes that share expression patterns with MIRLET7F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7F1 Gene

Orthologs for MIRLET7F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7F1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7f-1 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7f-1 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7f-1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7f 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm24111 34
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7e 34
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7f 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7f-2 34
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7f 34
  • 66 (a)
OneToOne
Species where no ortholog for MIRLET7F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7F1 Gene

ENSEMBL:
Gene Tree for MIRLET7F1 (if available)
TreeFam:
Gene Tree for MIRLET7F1 (if available)

Paralogs for MIRLET7F1 Gene

No data available for Paralogs for MIRLET7F1 Gene

Variants for MIRLET7F1 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7F1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001069410 -- 94,174,436(+) C/T upstream_transcript_variant
rs1001242486 -- 94,174,454(+) G/A upstream_transcript_variant
rs1001589170 -- 94,174,757(+) C/T upstream_transcript_variant
rs1002261112 -- 94,176,065(+) G/T upstream_transcript_variant
rs1002305969 -- 94,175,091(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F1 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Additional Variant Information for MIRLET7F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7F1 Gene

Disorders for MIRLET7F1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIRLET7F1 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
pancreatic cancer
  • pancreatic carcinoma
breast cancer
  • breast cancer, familial
colorectal cancer
  • crc
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7F1

genes like me logo Genes that share disorders with MIRLET7F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7F1 Gene

Publications for MIRLET7F1 Gene

  1. Reduced expression of let-7f activates TGF-β/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure. (PMID: 28345812) Dhahri W … Rivard A (Journal of cellular and molecular medicine 2017) 3 58
  2. Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3. (PMID: 27812761) Yao Y … Jia Y (Neurochemical research 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer. (PMID: 26847233) Li D … An R (Molecular medicine reports 2016) 3 58
  5. Circulating microRNAs as potential biomarkers for endometriosis. (PMID: 25772772) Cho S … Taylor HS (Fertility and sterility 2015) 3 58

Products for MIRLET7F1 Gene

Sources for MIRLET7F1 Gene

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