microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7F1 Gene

Data sources for MIRLET7F1 Gene:

RNA type for MIRLET7F1 Gene

miRNA

Aliases for MIRLET7F1 Gene

External Ids for MIRLET7F1 Gene

Previous HGNC Symbols for MIRLET7F1 Gene

  • MIRNLET7F1

Previous GeneCards Identifiers for MIRLET7F1 Gene

  • GC09P095983
  • GC09P096939
  • GC09P096943
  • GC09P096945
  • GC09P096951
  • GC09P096956
  • GC09P094177
  • GC09P094179
  • GC09P094195
  • GC09P094197
  • GC09P094199
  • GC09P094212
  • GC09P094180
  • GC09P094181
  • GC09P094182
  • GC09P094184
  • GC09P094186
  • GC09P094189
  • GC09P094191

Summaries for MIRLET7F1 Gene

Entrez Gene Summary for MIRLET7F1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7F1 Gene

MIRLET7F1 (MicroRNA Let-7f-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7F1 include Pituitary Adenoma and Pancreatic Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7F1 Gene

Additional gene information for MIRLET7F1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7F1 Gene

Genomics for MIRLET7F1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7F1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7F1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7F1 Gene

Latest Assembly
chr9:94,176,347-94,176,433
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr9:96,938,629-96,938,715
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

chr9:96,938,629-96,938,715
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIRLET7F1 Gene

Genes around MIRLET7F1 on UCSC Golden Path with GeneCards custom track
MIRLET7F1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7F1 Gene

Proteins for MIRLET7F1 Gene

Post-translational modifications for MIRLET7F1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7F1 Gene

Domains & Families for MIRLET7F1 Gene

Gene Families for MIRLET7F1 Gene

genes like me logo Genes that share domains with MIRLET7F1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7F1 Gene

Function for MIRLET7F1 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21508257
genes like me logo Genes that share ontologies with MIRLET7F1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7F1 Gene

Localization for MIRLET7F1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7F1 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIRLET7F1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7F1 Gene

Pathways & Interactions for MIRLET7F1 Gene

genes like me logo Genes that share pathways with MIRLET7F1: view

Pathways by source for MIRLET7F1 Gene

2 BioSystems pathways for MIRLET7F1 Gene
1 KEGG pathway for MIRLET7F1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 28345812
GO:0032007 negative regulation of TOR signaling IDA 21962509
GO:0032700 negative regulation of interleukin-17 production IDA 21508257
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043066 negative regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with MIRLET7F1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7F1 Gene

Drugs & Compounds for MIRLET7F1 Gene

No Compound Related Data Available

Transcripts for MIRLET7F1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7F1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003B7674_9606 miRNA 22 6

RefSeq: NR_029483, NR_029484,

LncBase: hsa-let-7f-5p,

miRBase: MIMAT0000067,

MirGeneDB: Hsa-Let-7-P2a3_5p, Hsa-Let-7-P2b1_5p,

TarBase: hsa-let-7f-5p,

ENA: View 6 records in RNAcentral

URS00004BFD1E_9606 pre_miRNA 87 5

RefSeq: NR_029483,

Ensembl: ENST00000362202 (view in UCSC) ,

miRBase: MI0000067,

Rfam: RF00027,

ENA: LM608156.1:1..87:precursor_RNA,

URS00002F8148_9606 miRNA 22 5

RefSeq: NR_029483,

LncBase: hsa-let-7f-1-3p,

miRBase: MIMAT0004486,

TarBase: hsa-let-7f-1-3p,

ENA: LM380166.1:1..22:ncRNA, LM608156.1:63..84:ncRNA,

URS0001BC00CD_9606 pre_miRNA 87 1

Rfam: RF00027,

URS0000EFC915_9606 pre_miRNA 78 1

MirGeneDB: Hsa-Let-7-P2b1,

MIRLET7F1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7F1 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7F1 Gene

No ASD Table

Relevant External Links for MIRLET7F1 Gene

GeneLoc Exon Structure for
MIRLET7F1

Expression for MIRLET7F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7F1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7F1

genes like me logo Genes that share expression patterns with MIRLET7F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7F1 Gene

Orthologs for MIRLET7F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7F1 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7f-1 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7f-1 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-let-7f 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7f-1 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm24111 30
  • 52 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7e 30
  • 46 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-let-7f 30
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7f-2 30
  • 54 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7f 30
  • 66 (a)
OneToOne
Species where no ortholog for MIRLET7F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7F1 Gene

ENSEMBL:
Gene Tree for MIRLET7F1 (if available)
TreeFam:
Gene Tree for MIRLET7F1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7F1

Paralogs for MIRLET7F1 Gene

No data available for Paralogs for MIRLET7F1 Gene

Variants for MIRLET7F1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7F1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7F1 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Additional Variant Information for MIRLET7F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7F1
Leiden Open Variation Database (LOVD)
MIRLET7F1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7F1 Gene

Disorders for MIRLET7F1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIRLET7F1 Gene - From: MID and COP

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
pancreatic cancer
  • pancreatic carcinoma
colorectal cancer
  • crc
lung cancer
  • lung cancer, susceptibility to
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7F1

genes like me logo Genes that share disorders with MIRLET7F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7F1 Gene

Publications for MIRLET7F1 Gene

  1. Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway. (PMID: 32305960) Chen G … Yin X (Aging 2020) 3
  2. Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus. (PMID: 32133007) Geng L … Sun L (Frontiers in immunology 2020) 3
  3. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  4. MicroRNA Let-7f-1-3p attenuates smoke-induced apoptosis in bronchial and alveolar epithelial cells in vitro by targeting FOXO1. (PMID: 31301310) Han Z … Meng Q (European journal of pharmacology 2019) 3
  5. Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. (PMID: 31545233) Tan W … Li G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3

Products for MIRLET7F1 Gene

Sources for MIRLET7F1 Gene