microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7E Gene

Data sources for MIRLET7E Gene:

RNA type for MIRLET7E Gene

miRNA

Aliases for MIRLET7E Gene

External Ids for MIRLET7E Gene

Previous HGNC Symbols for MIRLET7E Gene

  • MIRNLET7E

Previous GeneCards Identifiers for MIRLET7E Gene

  • GC19P056923
  • GC19P056927
  • GC19P052200
  • GC19P052204
  • GC19P052212
  • GC19P052220
  • GC19P051693
  • GC19P051697
  • GC19P051725
  • GC19P051732
  • GC19P051724
  • GC19P051722
  • GC19P051700
  • GC19P051704
  • GC19P051707
  • GC19P051711
  • GC19P051715

Summaries for MIRLET7E Gene

Entrez Gene Summary for MIRLET7E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7E Gene

MIRLET7E (MicroRNA Let-7e) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7E include Lung Cancer and Retinoblastoma. Among its related pathways are Gastric Cancer Network 2 and Toll-like Receptor Signaling Pathway.

Rfam classification for MIRLET7E Gene

Additional gene information for MIRLET7E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7E Gene

Genomics for MIRLET7E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051545 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 10.5 -143.4 -143411 7.2 NCOR1 IKZF1 MYC ZNF592 NFIC NONO REST SMAD5 HES1 BHLHE40 HSALNG0127226 SIGLEC6 ZNF175 ZNF841 ZNF808 ZNF616 ZNF836 SIGLEC8 SIGLEC14 ZNF350
GH19J051731 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.4 +45.8 45815 16.8 CTCF GABPA TAL1 ATF1 SPI1 MAX POLR2A ZNF384 TCF12 TEAD4 HSALNG0127254 FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E
GH19J051439 Promoter 0.6 Ensembl 9.9 -252.9 -252885 0.6 ZNF146 ZMYM3 KDM1A ZNF24 BCOR SIGLEC12 CEACAM18 VSIG10L RPL7P51 SIGLEC14 SIGLEC5 NKG7 ETFB CLDND2 MIR125A
GH19J051438 Enhancer 0.6 ENCODE 9.9 -254.4 -254374 0.1 IKZF1 CTCF REST TRIM22 SIN3A SMC3 YY1 RAD21 EHMT2 PKNOX1 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 NKG7 CLDND2 ETFB MIR125A
GH19J051687 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.3 -2295 6.9 NCOR1 IKZF1 ZNF580 ZSCAN16 NFIC ZIC2 ZBTB10 CTCF SMAD5 FEZF1 SPACA6 ZNF137P ZNF808 ZNF841 ZNF577 ZNF616 ZNF766 ZNF175 ZNF836 ENSG00000268970
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7E on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7E Gene

Latest Assembly
chr19:51,692,786-51,692,864
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,196,039-52,196,117
(GRCh37/hg19 by Entrez Gene)
Size:
79 bases
Orientation:
Plus strand

chr19:52,196,039-52,196,117
(GRCh37/hg19 by Ensembl)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIRLET7E Gene

Genes around MIRLET7E on UCSC Golden Path with GeneCards custom track
MIRLET7E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7E Gene

Proteins for MIRLET7E Gene

Post-translational modifications for MIRLET7E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7E Gene

Domains & Families for MIRLET7E Gene

Gene Families for MIRLET7E Gene

genes like me logo Genes that share domains with MIRLET7E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7E Gene

Function for MIRLET7E Gene

Phenotypes From GWAS Catalog for MIRLET7E Gene

Gene Ontology (GO) - Molecular Function for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIRLET7E: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7E Gene

Localization for MIRLET7E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7E gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIRLET7E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7E Gene

Pathways & Interactions for MIRLET7E Gene

genes like me logo Genes that share pathways with MIRLET7E: view

Pathways by source for MIRLET7E Gene

1 KEGG pathway for MIRLET7E Gene

Gene Ontology (GO) - Biological Process for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032715 negative regulation of interleukin-6 production IDA 30670152
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 30670152
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IGI 30670152
GO:0043433 negative regulation of DNA-binding transcription factor activity IDA 30670152
genes like me logo Genes that share ontologies with MIRLET7E: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7E Gene

Drugs & Compounds for MIRLET7E Gene

No Compound Related Data Available

Transcripts for MIRLET7E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7E Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000000B1C9_9606 miRNA 22 6

RefSeq: NR_029482,

LncBase: hsa-let-7e-5p,

miRBase: MIMAT0000066,

MirGeneDB: Hsa-Let-7-P1b_5p,

TarBase: hsa-let-7e-5p,

ENA: HB859638.1:1..22:misc_RNA, LM378753.1:1..22:ncRNA, LM608155.1:8..29:ncRNA,

URS0000409B45_9606 miRNA 22 6

RefSeq: NR_029482,

LncBase: hsa-let-7e-3p,

miRBase: MIMAT0004485,

MirGeneDB: Hsa-Let-7-P1b_3p,

TarBase: hsa-let-7e-3p,

ENA: AY940866.1:1..22:ncRNA, LM380165.1:1..22:ncRNA, LM608155.1:53..74:ncRNA,

URS000075DE48_9606 pre_miRNA 79 4

RefSeq: NR_029482,

Ensembl: ENST00000362102 (view in UCSC) ,

miRBase: MI0000066,

ENA: LM608155.1:1..79:precursor_RNA,

URS0000702A26_9606 pre_miRNA 77 1

Rfam: RF00027,

URS0001BC028B_9606 pre_miRNA 76 1

Rfam: RF00027,

MIRLET7E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7E Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7E Gene

No ASD Table

Relevant External Links for MIRLET7E Gene

GeneLoc Exon Structure for
MIRLET7E

Expression for MIRLET7E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7E

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7E Gene

Orthologs for MIRLET7E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7e 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7e 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-let-7e 30
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-1 30
  • 29 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-4 30
  • 58 (a)
ManyToMany
Species where no ortholog for MIRLET7E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7E Gene

ENSEMBL:
Gene Tree for MIRLET7E (if available)
TreeFam:
Gene Tree for MIRLET7E (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7E

Paralogs for MIRLET7E Gene

No data available for Paralogs for MIRLET7E Gene

Variants for MIRLET7E Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7E Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for MIRLET7E Gene

Human Gene Mutation Database (HGMD)
MIRLET7E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7E
Leiden Open Variation Database (LOVD)
MIRLET7E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7E Gene

Disorders for MIRLET7E Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIRLET7E Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
retinoblastoma
  • rb1
pituitary adenoma
  • adenoma of the pituitary gland
psoriasis
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7E

genes like me logo Genes that share disorders with MIRLET7E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7E Gene

Publications for MIRLET7E Gene

  1. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (PMID: 17437991) Lee YS … Dutta A (Genes & development 2007) 3 72
  2. Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis. (PMID: 32135185) Liu Y … Sun B (Life sciences 2020) 3
  3. Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1. (PMID: 31722968) Xiao M … Cai J (Molecular cancer research : MCR 2020) 3
  4. Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells. (PMID: 30670152) Park Y … Kim J (BMB reports 2019) 3
  5. Single nucleotide polymorphism rs10889677 in miRNAs Let-7e and Let-7f binding site of IL23R gene is a strong colorectal cancer determinant: Report and meta-analysis. (PMID: 31546198) Mosallaei M … Salehi R (Cancer genetics 2019) 3

Products for MIRLET7E Gene

Sources for MIRLET7E Gene