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Aliases for MIRLET7E Gene

Subcategory (RNA class) for MIRLET7E Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIRLET7E Gene

  • MicroRNA Let-7e 2 3 5
  • Hsa-Let-7e 3
  • MIRNLET7E 3
  • Let-7e 3
  • LET7E 3

External Ids for MIRLET7E Gene

ORGUL Members for MIRLET7E Gene

Previous HGNC Symbols for MIRLET7E Gene

  • MIRNLET7E

Previous GeneCards Identifiers for MIRLET7E Gene

  • GC19P056923
  • GC19P056927
  • GC19P052200
  • GC19P052204
  • GC19P052212
  • GC19P052220
  • GC19P051693
  • GC19P051697
  • GC19P051700
  • GC19P051704
  • GC19P051707
  • GC19P051711
  • GC19P051715

Summaries for MIRLET7E Gene

Entrez Gene Summary for MIRLET7E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7E Gene

MIRLET7E (MicroRNA Let-7e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Gastric Cancer Network 2 and MicroRNAs in cancer.

Additional gene information for MIRLET7E Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7E Gene

Genomics for MIRLET7E Gene

GeneHancer (GH) Regulatory Elements for MIRLET7E Gene

Promoters and enhancers for MIRLET7E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -143.0 -143013 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B SIGLEC6 ZNF175 ZNF841 ZNF616 ZNF836 ZNF808 SIGLEC14 SIGLEC8 ZNF350 CEACAM18
GH19I051748 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 10.8 +57.7 57715 5 CEBPB FPR1 FPR2 SIGLEC10 FPR3 SPACA6 MIR125A MIR99B MIRLET7E ZNF350 HAS1
GH19I051438 Enhancer 0.6 ENCODE 9.9 -254.4 -254374 0.1 CTCF PKNOX1 TRIM22 SIN3A MIER2 REST RAD21 IKZF1 ZNF143 ZNF444 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 NKG7 CLDND2 ETFB MIR125A
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.8 -2.3 -2295 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7E on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7E Gene

Genomic Locations for MIRLET7E Gene
chr19:51,692,786-51,692,864
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr19:52,196,039-52,196,117
(GRCh37/hg19)

Genomic View for MIRLET7E Gene

Genes around MIRLET7E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7E Gene

Proteins for MIRLET7E Gene

Post-translational modifications for MIRLET7E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7E Gene

Domains & Families for MIRLET7E Gene

Gene Families for MIRLET7E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7E Gene

Function for MIRLET7E Gene

Gene Ontology (GO) - Molecular Function for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23426184
genes like me logo Genes that share ontologies with MIRLET7E: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7E Gene

Localization for MIRLET7E Gene

Gene Ontology (GO) - Cellular Components for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIRLET7E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7E Gene

Pathways & Interactions for MIRLET7E Gene

genes like me logo Genes that share pathways with MIRLET7E: view

Pathways by source for MIRLET7E Gene

2 BioSystems pathways for MIRLET7E Gene
1 KEGG pathway for MIRLET7E Gene

Interacting Proteins for MIRLET7E Gene

Gene Ontology (GO) - Biological Process for MIRLET7E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23426184
genes like me logo Genes that share ontologies with MIRLET7E: view

No data available for SIGNOR curated interactions for MIRLET7E Gene

Drugs & Compounds for MIRLET7E Gene

No Compound Related Data Available

Transcripts for MIRLET7E Gene

mRNA/cDNA for MIRLET7E Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7E Gene

No ASD Table

Relevant External Links for MIRLET7E Gene

GeneLoc Exon Structure for
MIRLET7E
ECgene alternative splicing isoforms for
MIRLET7E

Expression for MIRLET7E Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7E Gene:

MIRLET7E
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7E Gene

Orthologs for MIRLET7E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7e 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7e 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7e 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7f-1 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-4 34
  • 58 (a)
ManyToMany
Species where no ortholog for MIRLET7E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7E Gene

ENSEMBL:
Gene Tree for MIRLET7E (if available)
TreeFam:
Gene Tree for MIRLET7E (if available)

Paralogs for MIRLET7E Gene

No data available for Paralogs for MIRLET7E Gene

Variants for MIRLET7E Gene

Sequence variations from dbSNP and Humsavar for MIRLET7E Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000093001 -- 51,690,920(+) /A upstream_transcript_variant
rs1000530929 -- 51,692,052(+) G/A upstream_transcript_variant
rs1000647040 -- 51,692,365(+) G/A upstream_transcript_variant
rs1003007762 -- 51,691,352(+) G/A upstream_transcript_variant
rs1003022639 -- 51,691,127(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7E Gene

Variant ID Type Subtype PubMed ID
nsv9742 CNV gain+loss 18304495
nsv953608 CNV deletion 24416366
nsv1140251 OTHER inversion 24896259
esv2758767 CNV gain+loss 17122850

Additional Variant Information for MIRLET7E Gene

Human Gene Mutation Database (HGMD)
MIRLET7E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7E Gene

Disorders for MIRLET7E Gene

Additional Disease Information for MIRLET7E

No disorders were found for MIRLET7E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7E Gene

Publications for MIRLET7E Gene

  1. Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair. (PMID: 28376831) Xiao M … Wang Z (Journal of ovarian research 2017) 3 58
  2. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
  3. MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1. (PMID: 28751193) Shan Y … Jia L (The international journal of biochemistry & cell biology 2017) 3 58
  4. ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. (PMID: 28408353) Ma J … Liu Z (Cancer letters 2017) 3 58
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58

Products for MIRLET7E Gene

Sources for MIRLET7E Gene

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