microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7D Gene

Subcategory (RNA class) for MIRLET7D Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIRLET7D Gene

  • MicroRNA Let-7d 2 3 5
  • Hsa-Let-7d-3p 163 173
  • Hsa-Let-7d-5p 163 173
  • Hsa-Let-7d 2 3
  • MIRLET7D 2 5
  • Hsa-Let-7-P2c1 178
  • MIMAT0000065 50
  • MIMAT0004484 50
  • MIRNLET7D 3
  • MI0000065 50
  • RF00027 168
  • Let-7d 3
  • LET7D 3

External Ids for MIRLET7D Gene

Previous HGNC Symbols for MIRLET7D Gene

  • MIRNLET7D

Previous GeneCards Identifiers for MIRLET7D Gene

  • GC09P095984
  • GC09P096941

Summaries for MIRLET7D Gene

Entrez Gene Summary for MIRLET7D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7D Gene

MIRLET7D (MicroRNA Let-7d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7D include Acute Promyelocytic Leukemia and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7D Gene

Additional gene information for MIRLET7D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7D Gene

Genomics for MIRLET7D Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MIRLET7D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7D Gene

Genomic Locations for MIRLET7D Gene
chr9:94,178,834-94,178,920
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr9:96,941,116-96,941,202
(GRCh37/hg19)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIRLET7D Gene

Genes around MIRLET7D on UCSC Golden Path with GeneCards custom track
MIRLET7D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7D Gene

Proteins for MIRLET7D Gene

Post-translational modifications for MIRLET7D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7D Gene

Domains & Families for MIRLET7D Gene

Gene Families for MIRLET7D Gene

genes like me logo Genes that share domains with MIRLET7D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7D Gene

Function for MIRLET7D Gene

Phenotypes From GWAS Catalog for MIRLET7D Gene

Animal Model Products

CRISPR Products

miRNA for MIRLET7D Gene

miRTarBase miRNAs that target MIRLET7D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIRLET7D Gene

Localization for MIRLET7D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7D gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIRLET7D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIRLET7D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7D Gene

Pathways & Interactions for MIRLET7D Gene

genes like me logo Genes that share pathways with MIRLET7D: view

Pathways by source for MIRLET7D Gene

2 BioSystems pathways for MIRLET7D Gene
1 KEGG pathway for MIRLET7D Gene

Gene Ontology (GO) - Biological Process for MIRLET7D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIRLET7D: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7D Gene

Drugs & Compounds for MIRLET7D Gene

No Compound Related Data Available

Transcripts for MIRLET7D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7D Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000A07C1_9606 miRNA 22 6

RefSeq: NR_029481,

LncBase: hsa-let-7d-5p,

miRBase: MIMAT0000065,

MirGeneDB: Hsa-Let-7-P2c1_5p,

TarBase: hsa-let-7d-5p,

ENA: HB859637.1:1..22:misc_RNA, LM378752.1:1..22:ncRNA, LM608154.1:8..29:ncRNA,

URS000075B243_9606 precursor_RNA 87 5

HGNC: 31481,

RefSeq: NR_029481,

Ensembl: ENST00000362263 (view in UCSC) ,

miRBase: MI0000065,

ENA: LM608154.1:1..87:precursor_RNA,

URS000028D142_9606 miRNA 22 5

RefSeq: NR_029481,

LncBase: hsa-let-7d-3p,

miRBase: MIMAT0004484,

TarBase: hsa-let-7d-3p,

ENA: LM380164.1:1..22:ncRNA, LM608154.1:62..83:ncRNA,

URS00004C105E_9606 precursor_RNA 85 1

Rfam: RF00027,

URS0000EFEEE4_9606 precursor_RNA 76 1

MirGeneDB: Hsa-Let-7-P2c1,

MIRLET7D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7D Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7D Gene

No ASD Table

Relevant External Links for MIRLET7D Gene

GeneLoc Exon Structure for
MIRLET7D

Expression for MIRLET7D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7D

Evidence on tissue expression from TISSUES for MIRLET7D Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with MIRLET7D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7D Gene

Orthologs for MIRLET7D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7D Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7d 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7d 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mirlet7d 31
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7d 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7d 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7d 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7d 31
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CR847944.3 31
  • 71 (a)
ManyToMany
Species where no ortholog for MIRLET7D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7D Gene

ENSEMBL:
Gene Tree for MIRLET7D (if available)
TreeFam:
Gene Tree for MIRLET7D (if available)

Paralogs for MIRLET7D Gene

No data available for Paralogs for MIRLET7D Gene

Variants for MIRLET7D Gene

Additional dbSNP identifiers (rs#s) for MIRLET7D Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7D Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Additional Variant Information for MIRLET7D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7D Gene

Disorders for MIRLET7D Gene

MalaCards: The human disease database

(47) MalaCards diseases for MIRLET7D Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7D

genes like me logo Genes that share disorders with MIRLET7D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7D Gene

Publications for MIRLET7D Gene

  1. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. (PMID: 31110176) Rubio K … Barreto G (Nature communications 2019) 3
  2. MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. (PMID: 30816441) Chen YN … Liu Y (International journal of oncology 2019) 3
  3. Regulation of HMGA2 and KRAS genes in epithelial ovarian cancer by miRNA hsa-let-7d-3p. (PMID: 31898667) Gunel T … Aydinli K (Journal of cancer research and therapeutics 2019) 3
  4. Let-7d modulates the proliferation, migration, tubulogenesis of endothelial cells. (PMID: 31435814) Ji X … Yi S (Molecular and cellular biochemistry 2019) 3
  5. Let-7d Inhibits Growth and Metastasis in Breast Cancer by Targeting Jab1/Cops5. (PMID: 29975923) Wei Y … Pan Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3

Products for MIRLET7D Gene

Sources for MIRLET7D Gene