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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIRLET7D Gene
Subcategory (RNA class) for MIRLET7D Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIRLET7D Gene
External Ids for MIRLET7D Gene
- HGNC: 31481
- Entrez Gene: 406886
- Ensembl: ENSG00000199133
- OMIM: 612145
- miRBase: hsa-let-7d
Previous HGNC Symbols for MIRLET7D Gene
- MIRNLET7D
Previous GeneCards Identifiers for MIRLET7D Gene
- GC09P095984
- GC09P096941
Summaries for MIRLET7D Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIRLET7D Gene
MIRLET7D (MicroRNA Let-7d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7D include Acute Promyelocytic Leukemia and Ovarian Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
Rfam classification for MIRLET7D Gene
-
let-7 microRNA precursor
Additional gene information for MIRLET7D Gene
- HGNC(31481)
- Entrez Gene(406886)
- Ensembl(ENSG00000199133)
- OMIM(612145)
- Open Targets Platform(ENSG00000199133)
- Search for MIRLET7D at DataMed
- Search for MIRLET7D at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7D Gene
Genomics for MIRLET7D Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIRLET7D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIRLET7D on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIRLET7D Gene
Genomic Locations for MIRLET7D Gene
- chr9:94,178,834-94,178,920
- (GRCh38/hg38)
- Size:
- 87 bases
- Orientation:
- Plus strand
- chr9:96,941,116-96,941,202
- (GRCh37/hg19)
- Size:
- 87 bases
- Orientation:
- Plus strand
Genomic View for MIRLET7D Gene
Genes around MIRLET7D on UCSC Golden Path with GeneCards custom track
MIRLET7D in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 9q22.32 by HGNC
- 9q22.32 by Entrez Gene
- 9q22.32 by Ensembl
MIRLET7D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIRLET7D Gene
Proteins for MIRLET7D Gene
Post-translational modifications for MIRLET7D Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7D
- Origene Custom Protein Services for MIRLET7D
No data available for DME Specific Peptides for MIRLET7D Gene
Domains & Families for MIRLET7D Gene
Gene Families for MIRLET7D Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7D Gene
Function for MIRLET7D Gene
Phenotypes From GWAS Catalog for MIRLET7D Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7D - Select products 50% OFF >
- * MIRLET7D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIRLET7D
miRNA for MIRLET7D Gene
- miRTarBase miRNAs that target MIRLET7D
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7D - Select products 50% OFF >
- * MIRLET7D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIRLET7D
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIRLET7D Gene
Localization for MIRLET7D Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7D Gene
Pathways & Interactions for MIRLET7D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
| 3 | miRNAs involved in DNA damage response | ||
Pathways by source for MIRLET7D Gene
2 BioSystems pathways for MIRLET7D Gene
1 KEGG pathway for MIRLET7D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7D Gene
Transcripts for MIRLET7D Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7D Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00000A07C1_9606 | miRNA | 22 | 6 |
RefSeq: NR_029481, LncBase: hsa-let-7d-5p, miRBase: MIMAT0000065, MirGeneDB: Hsa-Let-7-P2c1_5p, TarBase: hsa-let-7d-5p, ENA: HB859637.1:1..22:misc_RNA, LM378752.1:1..22:ncRNA, LM608154.1:8..29:ncRNA, |
| URS000075B243_9606 | precursor_RNA | 87 | 5 |
HGNC: 31481, RefSeq: NR_029481, Ensembl: ENST00000362263 (view in UCSC) , miRBase: MI0000065, |
| URS000028D142_9606 | miRNA | 22 | 5 |
RefSeq: NR_029481, LncBase: hsa-let-7d-3p, miRBase: MIMAT0004484, TarBase: hsa-let-7d-3p, |
| URS00004C105E_9606 | precursor_RNA | 85 | 1 |
Rfam: RF00027, |
| URS0000EFEEE4_9606 | precursor_RNA | 76 | 1 |
MirGeneDB: Hsa-Let-7-P2c1, |
MIRLET7D in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIRLET7D Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7D - Select products 50% OFF >
- * MIRLET7D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIRLET7D
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7D - Select products 50% OFF >
- * MIRLET7D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIRLET7D
Relevant External Links for MIRLET7D Gene
- GeneLoc Exon Structure for
- MIRLET7D
Expression for MIRLET7D Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7D
Evidence on tissue expression from TISSUES for MIRLET7D Gene
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for MIRLET7D
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7D Gene
Orthologs for MIRLET7D Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7d 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-let-7d 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mirlet7d 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7d 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-let-7d 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-let-7d 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-let-7d 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | CR847944.3 31 |
|
ManyToMany |
- Species where no ortholog for MIRLET7D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIRLET7D Gene
No data available for Paralogs for MIRLET7D Gene
Variants for MIRLET7D Gene
Additional Variant Information for MIRLET7D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIRLET7D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7D Gene
Disorders for MIRLET7D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute promyelocytic leukemia |
|
|
| ovarian cancer |
|
|
| lung cancer |
|
|
| non-alcoholic fatty liver disease |
|
|
| squamous cell carcinoma, head and neck |
|
Search MIRLET7D in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIRLET7D
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7D Gene
Publications for MIRLET7D Gene
- Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. (PMID: 31110176) Rubio K … Barreto G (Nature communications 2019) 3
- MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. (PMID: 30816441) Chen YN … Liu Y (International journal of oncology 2019) 3
- Regulation of HMGA2 and KRAS genes in epithelial ovarian cancer by miRNA hsa-let-7d-3p. (PMID: 31898667) Gunel T … Aydinli K (Journal of cancer research and therapeutics 2019) 3
- Let-7d modulates the proliferation, migration, tubulogenesis of endothelial cells. (PMID: 31435814) Ji X … Yi S (Molecular and cellular biochemistry 2019) 3
- Let-7d Inhibits Growth and Metastasis in Breast Cancer by Targeting Jab1/Cops5. (PMID: 29975923) Wei Y … Pan Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3
ExternalLinks
Products for MIRLET7D Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7D
- Origene Custom Protein Services for MIRLET7D
- Browse OriGene Inhibitory RNA Products For MIRLET7D
- OriGene qPCR primer pairs for MIRLET7D
- Browse CRISPR knockouts for MIRLET7D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIRLET7D
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIRLET7D
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIRLET7D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIRLET7D
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIRLET7D
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIRLET7D
Sources for MIRLET7D Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB