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MIRLET7D Gene(RNA Gene)

MicroRNA Let-7d

GCID:
GC09P094178
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIRLET7D Gene

Subcategory (RNA class) for MIRLET7D Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIRLET7D Gene

  • MicroRNA Let-7d 2 3 5
  • Hsa-Let-7d 3
  • MIRNLET7D 3
  • Let-7d 3
  • LET7D 3

External Ids for MIRLET7D Gene

ORGUL Members for MIRLET7D Gene

Previous HGNC Symbols for MIRLET7D Gene

  • MIRNLET7D

Previous GeneCards Identifiers for MIRLET7D Gene

  • GC09P095984
  • GC09P096941

Summaries for MIRLET7D Gene

Entrez Gene Summary for MIRLET7D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7D Gene

MIRLET7D (MicroRNA Let-7d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.

Additional gene information for MIRLET7D Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7D Gene

Genomics for MIRLET7D Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIRLET7D Gene

Promoters and enhancers for MIRLET7D Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09I094083 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.9 -93.9 -93870 2.1 MXI1 GTF2E2 MAX BMI1 ZIC2 ZNF644 ZFHX2 CTBP1 MTA3 POLR2A PTPDC1 MIRLET7D MIRLET7A1 MIRLET7F1 CYCSP24 LOC105376152
GH09I094156 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 -21.7 -21726 1.4 HDGF SMAD1 ATF1 FOXA2 ZNF766 ATF7 ZNF592 MEF2D GMEB1 SMARCA4 MIRLET7D LOC100132077 ENSG00000269946 LOC105376152
GH09I094065 Enhancer 0.9 Ensembl ENCODE 11.2 -113.1 -113133 0.6 CTCF IRF2 ZNF654 ARNT TRIM22 REST RAD21 CC2D1A MEF2D ARID2 MIRLET7A1 MIRLET7F1 MIRLET7D CYCSP24 PTPDC1 LOC105376152
GH09I094212 Enhancer 0.8 ENCODE 11.3 +33.8 33836 0.9 HDAC1 ATF1 CHAMP1 TCF12 ZNF766 GATA2 ATF7 CREM NCOA1 REST MIRLET7D MIRLET7A1 MIRLET7F1 ENSG00000269946 LOC100132077 MIRLET7DHG PIR33030
GH09I094110 Enhancer 0.8 ENCODE 10.7 -67.8 -67784 1 HDAC1 ATF1 PKNOX1 TAF9B ARNT NCOA2 TCF12 GATA2 ATF7 CEBPB MIRLET7A1 MIRLET7D MIRLET7F1 BARX1-AS1 LOC105376152 CYCSP24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7D on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7D Gene

Genomic Locations for MIRLET7D Gene
chr9:94,178,834-94,178,920
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr9:96,941,116-96,941,202
(GRCh37/hg19)

Genomic View for MIRLET7D Gene

Genes around MIRLET7D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7D Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIRLET7D Gene

Proteins for MIRLET7D Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIRLET7D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7D Gene

Domains & Families for MIRLET7D Gene

Gene Families for MIRLET7D Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7D Gene

Function for MIRLET7D Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA for MIRLET7D Gene

miRTarBase miRNAs that target MIRLET7D

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIRLET7D Gene

Localization for MIRLET7D Gene

Gene Ontology (GO) - Cellular Components for MIRLET7D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIRLET7D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7D Gene

Pathways & Interactions for MIRLET7D Gene

genes like me logo Genes that share pathways with MIRLET7D: view

Pathways by source for MIRLET7D Gene

2 BioSystems pathways for MIRLET7D Gene
1 KEGG pathway for MIRLET7D Gene

Interacting Proteins for MIRLET7D Gene

Gene Ontology (GO) - Biological Process for MIRLET7D Gene

None

No data available for SIGNOR curated interactions for MIRLET7D Gene

Drugs & Compounds for MIRLET7D Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIRLET7D Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIRLET7D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7D Gene

No ASD Table

Relevant External Links for MIRLET7D Gene

GeneLoc Exon Structure for
MIRLET7D
ECgene alternative splicing isoforms for
MIRLET7D

Expression for MIRLET7D Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7D Gene

mRNA expression in normal human tissues for MIRLET7D Gene
mRNA expression by GTEx for MIRLET7D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7D Gene:

MIRLET7D
genes like me logo Genes that share expression patterns with MIRLET7D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7D Gene

Orthologs for MIRLET7D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7D Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia -- 34
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-let-7d 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-let-7d 34
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mirlet7d 34
  • 77 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-let-7d 34
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-let-7d 34
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-let-7d 34
  • 76 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-let-7d 34
  • 64 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii CR847944.3 34
  • 71 (a)
 ManyToMany
Species where no ortholog for MIRLET7D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7D Gene

ENSEMBL:
Gene Tree for MIRLET7D (if available)
TreeFam:
Gene Tree for MIRLET7D (if available)

Paralogs for MIRLET7D Gene

No data available for Paralogs for MIRLET7D Gene

Variants for MIRLET7D Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIRLET7D Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000798696 -- 94,179,002(+) G/T downstream_transcript_variant
rs1001770030 -- 94,179,362(+) G/A downstream_transcript_variant
rs1005217701 -- 94,177,081(+) G/A upstream_transcript_variant
rs1006321302 -- 94,178,034(+) C/T upstream_transcript_variant
rs1006679205 -- 94,178,270(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7D Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Additional Variant Information for MIRLET7D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7D Gene

Disorders for MIRLET7D Gene

Additional Disease Information for MIRLET7D

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIRLET7D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7D Gene

Publications for MIRLET7D Gene

  1. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
  2. Different levels of let-7d expression modulate response of FaDu cells to irradiation and chemotherapeutics. (PMID: 28665983) Lamperska KM … Kozlowski P (PloS one 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. (PMID: 26679758) Di Fiore R … Vento R (Journal of cellular physiology 2016) 3 58
  5. miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF. (PMID: 26787543) Liang H … Shan H (Journal of molecular medicine (Berlin, Germany) 2016) 3 58

Products for MIRLET7D Gene

Sources for MIRLET7D Gene

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