microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7C Gene

Subcategory (RNA class) for MIRLET7C Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIRLET7C Gene

  • MicroRNA Let-7c 2 3 5
  • Hsa-Let-7c-5p 163 173
  • Hsa-Let-7c 2 3
  • MIRLET7C 2 5
  • Hsa-Let-7-P1c 178
  • MIMAT0000064 50
  • MIMAT0026472 50
  • MIRNLET7C 3
  • MI0000064 50
  • RF00027 168
  • Let-7c 3
  • LET7C 3

External Ids for MIRLET7C Gene

Previous HGNC Symbols for MIRLET7C Gene

  • MIRNLET7C

Previous GeneCards Identifiers for MIRLET7C Gene

  • GC21P016842
  • GC21P017912
  • GC21P016540
  • GC21P016541
  • GC21P016557
  • GC21P016559
  • GC21P016555
  • GC21P016553
  • GC21P016542
  • GC21P016544
  • GC21P016545
  • GC21P016547
  • GC21P016549

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7C include Leiomyoma, Uterine and Burkitt Lymphoma. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7C Gene

Additional gene information for MIRLET7C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J016586 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +47.9 47917 3 PRDM10 FOXA1 PRDM1 POLR2A PATZ1 SP1 ZNF341 CEBPA SOX13 CEBPB MIR99AHG MIR99A MIRLET7C MIR125B2 ENSG00000269950 CXADR USP25
GH21J016578 Enhancer 1.3 VISTA UCNEbase Ensembl ENCODE CraniofacialAtlas 11.5 +40.2 40212 2.7 MAFF MAFK MIR99A MIRLET7C ENSG00000269950 lnc-BTG3-10 lnc-USP25-11 MIR99AHG USP25 CXADR
GH21J016570 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.6 +31.2 31243 3.1 FOXA1 NFE2 CEBPB EP300 MAFK NFE2L2 ATF2 MAFF ZNF680 MIR99A MIRLET7C lnc-BTG3-10 lnc-USP25-11 MIR99AHG USP25 CXADR
GH21J016563 Enhancer 0.9 Ensembl ENCODE 11.7 +24.1 24141 1.7 TEAD4 FOXA1 SOX13 ETS1 SP1 ESR1 CEBPB CHD2 RCOR1 YY1 MIR99A MIRLET7C lnc-USP25-11 lnc-BTG3-10 MIR99AHG USP25 CXADR
GH21J016573 Enhancer 0.5 Ensembl ENCODE dbSUPER 11.6 +34.0 33996 1.6 MIR99A MIRLET7C lnc-BTG3-10 lnc-USP25-11 MIR99AHG USP25 CXADR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7C Gene

Genomic Locations for MIRLET7C Gene
chr21:16,539,828-16,539,911
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr21:17,912,143-17,912,236
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIRLET7C Gene

Genes around MIRLET7C on UCSC Golden Path with GeneCards custom track
MIRLET7C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains & Families for MIRLET7C Gene

Gene Families for MIRLET7C Gene

genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

Gene Ontology (GO) - Molecular Function for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22042811
genes like me logo Genes that share ontologies with MIRLET7C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7C gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7C Gene

Pathways & Interactions for MIRLET7C Gene

PathCards logo

SuperPathways for MIRLET7C Gene

genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 BioSystems pathway for MIRLET7C Gene
1 KEGG pathway for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045081 negative regulation of interleukin-10 biosynthetic process IDA 22835429
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 29582468
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA 26455324
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7C Gene

Drugs & Compounds for MIRLET7C Gene

No Compound Related Data Available

Transcripts for MIRLET7C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7C Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000050DE77_9606 miRNA 22 6

RefSeq: NR_029480,

LncBase: hsa-let-7c-5p,

miRBase: MIMAT0000064,

MirGeneDB: Hsa-Let-7-P1c_5p,

TarBase: hsa-let-7c-5p,

ENA: AJ421728.1:1..22:misc_RNA, HB859636.1:1..22:misc_RNA, LM378751.1:1..22:ncRNA, LM608153.1:11..32:ncRNA,

URS0000031E12_9606 precursor_RNA 84 5

HGNC: 31480,

RefSeq: NR_029480,

Ensembl: ENST00000362160 (view in UCSC) ,

miRBase: MI0000064,

ENA: LM608153.1:1..84:precursor_RNA,

URS000060A34C_9606 miRNA 22 4

RefSeq: NR_029480,

miRBase: MIMAT0026472,

MirGeneDB: Hsa-Let-7-P1c_3p,

ENA: AB372796.1:1..22:ncRNA, LM383141.1:1..22:ncRNA, LM608153.1:56..77:ncRNA,

URS00002DE03A_9606 precursor_RNA 76 1

Rfam: RF00027,

URS0000EFE150_9606 precursor_RNA 68 1

MirGeneDB: Hsa-Let-7-P1c,

MIRLET7C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7C Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
MIRLET7C

Expression for MIRLET7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7C

Evidence on tissue expression from TISSUES for MIRLET7C Gene

  • Blood(2.3)
  • Liver(2.1)
  • Kidney(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MIRLET7C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7C Gene

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-let-7c 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7c 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7c 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 31 31
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mirlet7c-1 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7c 31
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7c-1 31
  • 100 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7c-1 31
  • 64 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 31
  • 46 (a)
OneToMany
Species where no ortholog for MIRLET7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

ENSEMBL:
Gene Tree for MIRLET7C (if available)
TreeFam:
Gene Tree for MIRLET7C (if available)

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

Additional dbSNP identifiers (rs#s) for MIRLET7C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Additional Variant Information for MIRLET7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7C Gene

Disorders for MIRLET7C Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIRLET7C Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma, uterine
  • ul
burkitt lymphoma
  • bl
prostate cancer
  • prostate cancer, somatic
acute promyelocytic leukemia
  • apl
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIRLET7C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. Evaluating prognostic utility of preoperative Neutrophil to Lymphocyte Ratio and hsa-let-7g/c up-regulation in patients with urinary bladder cancer. (PMID: 31683460) Boubaker NS … Ouerhani S (Cancer biomarkers : section A of Disease markers 2020) 3
  2. LIN28B regulates androgen receptor in human trophoblast cells through Let-7c. (PMID: 31215730) McWhorter ES … Bouma GJ (Molecular reproduction and development 2019) 3
  3. H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells. (PMID: 30338598) Wang M … Sun X (Cell proliferation 2019) 3
  4. The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies. (PMID: 30789054) Zhang HH … Tang LF (Journal of evidence-based integrative medicine 2019) 3
  5. miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy. (PMID: 31118065) Tang H … Guo J (Journal of experimental & clinical cancer research : CR 2019) 3

Products for MIRLET7C Gene

Sources for MIRLET7C Gene