microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7C Gene

Data sources for MIRLET7C Gene:

RNA type for MIRLET7C Gene

miRNA

Aliases for MIRLET7C Gene

External Ids for MIRLET7C Gene

Previous HGNC Symbols for MIRLET7C Gene

  • MIRNLET7C

Previous GeneCards Identifiers for MIRLET7C Gene

  • GC21P016842
  • GC21P017912
  • GC21P016540
  • GC21P016541
  • GC21P016557
  • GC21P016559
  • GC21P016555
  • GC21P016553
  • GC21P016542
  • GC21P016544
  • GC21P016545
  • GC21P016547
  • GC21P016549

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7C include Leiomyoma, Uterine and Burkitt Lymphoma. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MIRLET7C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7C Gene

Latest Assembly
chr21:16,539,828-16,539,911
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand

Previous Assembly
chr21:17,912,148-17,912,231
(GRCh37/hg19 by Entrez Gene)
Size:
84 bases
Orientation:
Plus strand

chr21:17,912,143-17,912,236
(GRCh37/hg19 by Ensembl)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIRLET7C Gene

Genes around MIRLET7C on UCSC Golden Path with GeneCards custom track
MIRLET7C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains & Families for MIRLET7C Gene

Gene Families for MIRLET7C Gene

genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

Gene Ontology (GO) - Molecular Function for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22042811
genes like me logo Genes that share ontologies with MIRLET7C: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7C gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
GO:0070062 extracellular exosome IDA 31926946
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7C Gene

Pathways & Interactions for MIRLET7C Gene

PathCards logo

SuperPathways for MIRLET7C Gene

genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 BioSystems pathway for MIRLET7C Gene
1 KEGG pathway for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032693 negative regulation of interleukin-10 production IDA 22835429
GO:0032717 negative regulation of interleukin-8 production IDA 29582468
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA 26455324
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7C Gene

Drugs & Compounds for MIRLET7C Gene

No Compound Related Data Available

Transcripts for MIRLET7C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7C Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000050DE77_9606 miRNA 22 6

RefSeq: NR_029480,

LncBase: hsa-let-7c-5p,

miRBase: MIMAT0000064,

MirGeneDB: Hsa-Let-7-P1c_5p,

TarBase: hsa-let-7c-5p,

ENA: AJ421728.1:1..22:misc_RNA, HB859636.1:1..22:misc_RNA, LM378751.1:1..22:ncRNA, LM608153.1:11..32:ncRNA,

URS0000031E12_9606 pre_miRNA 84 4

RefSeq: NR_029480,

Ensembl: ENST00000362160 (view in UCSC) ,

miRBase: MI0000064,

ENA: LM608153.1:1..84:precursor_RNA,

URS000060A34C_9606 miRNA 22 4

RefSeq: NR_029480,

miRBase: MIMAT0026472,

MirGeneDB: Hsa-Let-7-P1c_3p,

ENA: AB372796.1:1..22:ncRNA, LM383141.1:1..22:ncRNA, LM608153.1:56..77:ncRNA,

URS00002DE03A_9606 pre_miRNA 76 1

Rfam: RF00027,

URS0001BC4F66_9606 pre_miRNA 76 1

Rfam: RF00027,

MIRLET7C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7C Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
MIRLET7C

Expression for MIRLET7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7C

Evidence on tissue expression from TISSUES for MIRLET7C Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIRLET7C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7C Gene

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-let-7c 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7c 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7c 30
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 30 30
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mirlet7c-1 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7c 30
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-let-7c-1 30
  • 100 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7c-1 30
  • 64 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 30
  • 46 (a)
OneToMany
Species where no ortholog for MIRLET7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

ENSEMBL:
Gene Tree for MIRLET7C (if available)
TreeFam:
Gene Tree for MIRLET7C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7C

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Additional Variant Information for MIRLET7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7C
Leiden Open Variation Database (LOVD)
MIRLET7C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7C Gene

Disorders for MIRLET7C Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIRLET7C Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
leiomyoma, uterine
  • ul
burkitt lymphoma
  • bl
acute promyelocytic leukemia
  • apl
prostate cancer
  • prostate cancer, somatic
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7C

genes like me logo Genes that share disorders with MIRLET7C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. (PMID: 19372056) Leite KR … Srougi M (Urologic oncology 2011) 3 72
  2. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui WO … Fire A (Cancer research 2007) 3 72
  3. Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells. (PMID: 32258130) Li T … Yan Q (BioMed research international 2020) 3
  4. The let-7c/HoxB7 axis regulates the cell proliferation, migration and apoptosis in hepatocellular carcinoma. (PMID: 31609764) Cai L … Xu L (Anti-cancer drugs 2020) 3
  5. Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations. (PMID: 32641854) Li XF … Zhang J (Scientific reports 2020) 3

Products for MIRLET7C Gene

Sources for MIRLET7C Gene