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Aliases for MIRLET7C Gene

Subcategory (RNA class) for MIRLET7C Gene

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Quality Score for this RNA gene is

3

Aliases for MIRLET7C Gene

  • MicroRNA Let-7c 2 3 5
  • Hsa-Let-7c 3
  • MIRNLET7C 3
  • Let-7c 3
  • LET7C 3

External Ids for MIRLET7C Gene

ORGUL Members for MIRLET7C Gene

Previous HGNC Symbols for MIRLET7C Gene

  • MIRNLET7C

Previous GeneCards Identifiers for MIRLET7C Gene

  • GC21P016842
  • GC21P017912
  • GC21P016540
  • GC21P016541
  • GC21P016542
  • GC21P016544
  • GC21P016545
  • GC21P016547
  • GC21P016549

Summaries for MIRLET7C Gene

Entrez Gene Summary for MIRLET7C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7C Gene

MIRLET7C (MicroRNA Let-7c) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIRLET7C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIRLET7C Gene

Genomics for MIRLET7C Gene

GeneHancer (GH) Regulatory Elements for MIRLET7C Gene

Promoters and enhancers for MIRLET7C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I016586 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +47.9 47917 3 ELF3 FOXA2 SIN3A RAD21 RFX5 YY1 ZNF335 GLIS2 ZNF143 RCOR1 MIR99A MIRLET7C MIR125B2 ENSG00000269950 MIR99AHG
GH21I016578 Enhancer 1.4 VISTA UCNEbase Ensembl ENCODE 11.5 +40.2 40188 2.6 MAFF MAFK MIR99A MIRLET7C ENSG00000269950 GC21P016557 PIR42144 MIR99AHG
GH21I016563 Enhancer 0.9 Ensembl ENCODE 11.7 +24.1 24122 1.2 SOX13 MAX RAD21 ETS1 RFX5 TEAD3 GATA3 RCOR1 CHD2 TCF7L2 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016557 MIR99AHG
GH21I016570 Enhancer 0.7 ENCODE dbSUPER 11.6 +30.6 30599 0.4 MAFF CEBPB NFE2 EP300 NFE2L2 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016557 MIR99AHG
GH21I016573 Enhancer 0.6 Ensembl ENCODE dbSUPER 11.6 +34.0 34025 1.6 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016557 MIR99AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIRLET7C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7C Gene

Genomic Locations for MIRLET7C Gene
chr21:16,539,828-16,539,911
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr21:17,912,143-17,912,236
(GRCh37/hg19)

Genomic View for MIRLET7C Gene

Genes around MIRLET7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7C Gene

Proteins for MIRLET7C Gene

Post-translational modifications for MIRLET7C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7C Gene

Domains & Families for MIRLET7C Gene

Gene Families for MIRLET7C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7C Gene

Function for MIRLET7C Gene

Gene Ontology (GO) - Molecular Function for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22042811
genes like me logo Genes that share ontologies with MIRLET7C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7C Gene

Localization for MIRLET7C Gene

Gene Ontology (GO) - Cellular Components for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7C Gene

Pathways & Interactions for MIRLET7C Gene

genes like me logo Genes that share pathways with MIRLET7C: view

Pathways by source for MIRLET7C Gene

1 BioSystems pathway for MIRLET7C Gene
1 KEGG pathway for MIRLET7C Gene

Interacting Proteins for MIRLET7C Gene

Gene Ontology (GO) - Biological Process for MIRLET7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 22042811
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
genes like me logo Genes that share ontologies with MIRLET7C: view

No data available for SIGNOR curated interactions for MIRLET7C Gene

Drugs & Compounds for MIRLET7C Gene

No Compound Related Data Available

Transcripts for MIRLET7C Gene

mRNA/cDNA for MIRLET7C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7C Gene

No ASD Table

Relevant External Links for MIRLET7C Gene

GeneLoc Exon Structure for
MIRLET7C
ECgene alternative splicing isoforms for
MIRLET7C

Expression for MIRLET7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7C Gene:

MIRLET7C
genes like me logo Genes that share expression patterns with MIRLET7C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7C Gene

Orthologs for MIRLET7C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-let-7c 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7c 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7c 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-let-7c-2 34 34
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mirlet7c-1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7c 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-let-7c-1 34
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7c-1 34
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 34
  • 46 (a)
OneToMany
Species where no ortholog for MIRLET7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7C Gene

ENSEMBL:
Gene Tree for MIRLET7C (if available)
TreeFam:
Gene Tree for MIRLET7C (if available)

Paralogs for MIRLET7C Gene

No data available for Paralogs for MIRLET7C Gene

Variants for MIRLET7C Gene

Sequence variations from dbSNP and Humsavar for MIRLET7C Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1001234213 -- 16,538,598(+) G/A upstream_transcript_variant
rs1001266684 -- 16,538,886(+) A/T upstream_transcript_variant
rs1002553262 -- 16,538,512(+) T/A upstream_transcript_variant
rs1002911021 -- 16,540,100(+) A/G downstream_transcript_variant
rs1002942101 -- 16,540,314(+) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7C Gene

Variant ID Type Subtype PubMed ID
esv3893374 CNV loss 25118596
esv2723192 CNV deletion 23290073

Additional Variant Information for MIRLET7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7C Gene

Disorders for MIRLET7C Gene

Additional Disease Information for MIRLET7C

No disorders were found for MIRLET7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIRLET7C Gene

Publications for MIRLET7C Gene

  1. MiR-199a-5p and let-7c cooperatively inhibit migration and invasion by targeting MAP4K3 in hepatocellular carcinoma. (PMID: 28099144) Liu L … Wu G (Oncotarget 2017) 3 58
  2. Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells. (PMID: 28184029) Lu L … Bian Q (Oncotarget 2017) 3 58
  3. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. (PMID: 28694731) Fedorko M … Slaby O (Biochemia medica 2017) 3 58
  4. let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery. (PMID: 28604753) Spolverini A … Oren M (Oncogene 2017) 3 58
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58

Products for MIRLET7C Gene

Sources for MIRLET7C Gene

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