microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7B Gene

Subcategory (RNA class) for MIRLET7B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIRLET7B Gene

  • MicroRNA Let-7b 2 3 5
  • Hsa-Let-7b-5p 163 173
  • Hsa-Let-7b-3p 163 173
  • Hsa-Let-7b 2 3
  • MIRLET7B 2 5
  • Hsa-Let-7-P2b2 178
  • MIMAT0004482 50
  • MIMAT0000063 50
  • MIRNLET7B 3
  • MI0000063 50
  • RF00027 168
  • Let-7b 3
  • LET7B 3

External Ids for MIRLET7B Gene

Previous HGNC Symbols for MIRLET7B Gene

  • MIRNLET7B

Previous GeneCards Identifiers for MIRLET7B Gene

  • GC22P044889
  • GC22P046509
  • GC22P046114
  • GC22P046115
  • GC22P046122
  • GC22P046123
  • GC22P046121
  • GC22P046120
  • GC22P046116
  • GC22P046056
  • GC22P046117
  • GC22P046118

Summaries for MIRLET7B Gene

Entrez Gene Summary for MIRLET7B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7B Gene

MIRLET7B (MicroRNA Let-7b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7B include Melanoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7B Gene

Additional gene information for MIRLET7B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7B Gene

Genomics for MIRLET7B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J046111 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.7 730 5.6 HNRNPL CTCF PRDM10 ZNF629 ZNF692 ZNF143 ZIC2 RXRB PATZ1 REST MIR4763 MIRLET7A3 MIRLET7B HSALNG0136001 PPARA MIRLET7BHG ENSG00000273145 WNT7B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7B Gene

Genomic Locations for MIRLET7B Gene
chr22:46,113,685-46,113,769
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr22:46,509,566-46,509,648
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIRLET7B Gene

Genes around MIRLET7B on UCSC Golden Path with GeneCards custom track
MIRLET7B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7B Gene

Proteins for MIRLET7B Gene

Post-translational modifications for MIRLET7B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7B Gene

Domains & Families for MIRLET7B Gene

Gene Families for MIRLET7B Gene

genes like me logo Genes that share domains with MIRLET7B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7B Gene

Function for MIRLET7B Gene

Gene Ontology (GO) - Molecular Function for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIRLET7B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7B Gene

Localization for MIRLET7B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIRLET7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7B Gene

Pathways & Interactions for MIRLET7B Gene

PathCards logo

SuperPathways for MIRLET7B Gene

genes like me logo Genes that share pathways with MIRLET7B: view

Pathways by source for MIRLET7B Gene

1 BioSystems pathway for MIRLET7B Gene
1 KEGG pathway for MIRLET7B Gene

Gene Ontology (GO) - Biological Process for MIRLET7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010507 negative regulation of autophagy IDA 26296645
GO:0034614 cellular response to reactive oxygen species IDA 26296645
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 26296645
GO:0045766 positive regulation of angiogenesis IDA 26296645
genes like me logo Genes that share ontologies with MIRLET7B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7B Gene

Drugs & Compounds for MIRLET7B Gene

No Compound Related Data Available

Transcripts for MIRLET7B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000324096_9606 miRNA 22 6

RefSeq: NR_029479,

LncBase: hsa-let-7b-5p,

miRBase: MIMAT0000063,

MirGeneDB: Hsa-Let-7-P2b2_5p,

TarBase: hsa-let-7b-5p,

ENA: AJ421727.1:1..22:misc_RNA, HB859655.1:1..22:misc_RNA, LM378750.1:1..22:ncRNA, LM608152.1:6..27:ncRNA,

URS000075A6A4_9606 precursor_RNA 83 5

HGNC: 31479,

RefSeq: NR_029479,

Ensembl: ENST00000385140 (view in UCSC) ,

miRBase: MI0000063,

ENA: LM608152.1:1..83:precursor_RNA,

URS00005918D5_9606 miRNA 22 5

RefSeq: NR_029479,

LncBase: hsa-let-7b-3p,

miRBase: MIMAT0004482,

TarBase: hsa-let-7b-3p,

ENA: LM380163.1:1..22:ncRNA, LM608152.1:60..81:ncRNA,

URS0000631FB7_9606 precursor_RNA 85 1

Rfam: RF00027,

URS0000EFC4FB_9606 precursor_RNA 76 1

MirGeneDB: Hsa-Let-7-P2b2,

MIRLET7B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7B Gene

No ASD Table

Relevant External Links for MIRLET7B Gene

GeneLoc Exon Structure for
MIRLET7B

Expression for MIRLET7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7B Gene

Evidence on tissue expression from TISSUES for MIRLET7B Gene

  • Blood(2.4)
  • Nervous system(2.3)
  • Liver(2.2)
  • Skin(2.1)
  • Muscle(2.1)
  • Intestine(2.1)
  • Heart(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MIRLET7B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7B Gene

Orthologs for MIRLET7B Gene

Evolution for MIRLET7B Gene

ENSEMBL:
Gene Tree for MIRLET7B (if available)
TreeFam:
Gene Tree for MIRLET7B (if available)

No data available for Orthologs for MIRLET7B Gene

Paralogs for MIRLET7B Gene

No data available for Paralogs for MIRLET7B Gene

Variants for MIRLET7B Gene

Additional dbSNP identifiers (rs#s) for MIRLET7B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7B Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Additional Variant Information for MIRLET7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7B Gene

Disorders for MIRLET7B Gene

MalaCards: The human disease database

(43) MalaCards diseases for MIRLET7B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
lung cancer
  • adenocarcinoma of lung
primary biliary cirrhosis
  • pbc
melanoma, uveal
  • uveal melanoma
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIRLET7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7B Gene

Publications for MIRLET7B Gene

  1. Hsa-let-7b Suppresses Cell Proliferation by Targeting UHRF1 in Melanoma. (PMID: 31873045) Lu NH … Gu JY (Cancer investigation 2020) 3
  2. Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis. (PMID: 30483747) Zhang Y … Zhang Y (International journal of molecular medicine 2019) 3
  3. Let-7b-5p inhibits proliferation and motility in squamous cell carcinoma cells through negative modulation of KIAA1377. (PMID: 30958603) Zheng S … Lu X (Cell biology international 2019) 3
  4. Bcl-xL/Bak interaction and regulation by miRNA let-7b in the intrinsic apoptotic pathway of stored platelets. (PMID: 29125379) Yan Y … Xia R (Platelets 2019) 3
  5. An in vitro and in vivo study of the role of long non-coding RNA-HOST2 in the proliferation, migration, and invasion of human glioma cells. (PMID: 30290058) Wang Q … Zhang KM (IUBMB life 2019) 3

Products for MIRLET7B Gene

Sources for MIRLET7B Gene