microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7A3 Gene

Data sources for MIRLET7A3 Gene:

RNA type for MIRLET7A3 Gene

miRNA

Aliases for MIRLET7A3 Gene

External Ids for MIRLET7A3 Gene

Previous HGNC Symbols for MIRLET7A3 Gene

  • MIRNLET7A3

Previous GeneCards Identifiers for MIRLET7A3 Gene

  • GC22P044887
  • GC22P046508
  • GC22P046058

Summaries for MIRLET7A3 Gene

Entrez Gene Summary for MIRLET7A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A3 Gene

MIRLET7A3 (MicroRNA Let-7a-3) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A3 include Ovarian Epithelial Cancer and Acute Promyelocytic Leukemia. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7A3 Gene

Additional gene information for MIRLET7A3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A3 Gene

Genomics for MIRLET7A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J046111 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.7 1715 5.5 ZNF600 ZNF654 ZNF223 ZIC2 ZBTB10 YY1 CTCF REST ZNF592 TARDBP MIR4763 MIRLET7A3 MIRLET7B HSALNG0136000 HSALNG0136001 PPARA MIRLET7BHG ENSG00000273145 WNT7B
GH22J046096 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.8 -8816 14.9 ZMYM3 CEBPA ZIC2 ZBTB10 YY1 ZNF341 CTCF KLF9 SP2 RXRA GTSE1 MIRLET7BHG PPARA PRR34 HSALNG0135999 MIRLET7A3 LOC112268288 ENSG00000273145 WNT7B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7A3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7A3 Gene

Latest Assembly
chr22:46,112,746-46,112,824
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand

Previous Assembly
chr22:46,508,629-46,508,702
(GRCh37/hg19 by Entrez Gene)
Size:
74 bases
Orientation:
Plus strand

Genomic View for MIRLET7A3 Gene

Genes around MIRLET7A3 on UCSC Golden Path with GeneCards custom track
MIRLET7A3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A3 Gene

Proteins for MIRLET7A3 Gene

Post-translational modifications for MIRLET7A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A3 Gene

Domains & Families for MIRLET7A3 Gene

Gene Families for MIRLET7A3 Gene

genes like me logo Genes that share domains with MIRLET7A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7A3 Gene

Function for MIRLET7A3 Gene

Phenotypes From GWAS Catalog for MIRLET7A3 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIRLET7A3: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A3 Gene

Localization for MIRLET7A3 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:0070062 extracellular exosome IDA --
GO:1903561 extracellular vesicle HDA --
genes like me logo Genes that share ontologies with MIRLET7A3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A3 Gene

Pathways & Interactions for MIRLET7A3 Gene

PathCards logo

SuperPathways for MIRLET7A3 Gene

genes like me logo Genes that share pathways with MIRLET7A3: view

Pathways by source for MIRLET7A3 Gene

1 BioSystems pathway for MIRLET7A3 Gene
1 KEGG pathway for MIRLET7A3 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA --
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA --
GO:0098806 deadenylation involved in gene silencing by miRNA IMP --
genes like me logo Genes that share ontologies with MIRLET7A3: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7A3 Gene

Drugs & Compounds for MIRLET7A3 Gene

No Compound Related Data Available

Transcripts for MIRLET7A3 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7A3 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000416056_9606 miRNA 22 6

RefSeq: NR_029476, NR_029477, NR_029478,

LncBase: hsa-let-7a-5p,

miRBase: MIMAT0000062,

MirGeneDB: Hsa-Let-7-P1a_5p, Hsa-Let-7-P2a1_5p, Hsa-Let-7-P2a2_5p,

TarBase: hsa-let-7a-5p,

ENA: View 8 records in RNAcentral

URS000004F5D8_9606 miRNA 21 6

RefSeq: NR_029476, NR_029478,

LncBase: hsa-let-7a-3p,

miRBase: MIMAT0004481,

MirGeneDB: Hsa-Let-7-P2a1_3p, Hsa-Let-7-P2a2_3p,

TarBase: hsa-let-7a-3p,

ENA: LM380162.1:1..21:ncRNA, LM608149.1:57..77:ncRNA, LM608151.1:52..72:ncRNA,

URS00004BC34C_9606 pre_miRNA 74 4

RefSeq: NR_029478,

Ensembl: ENST00000362116 (view in UCSC) ,

miRBase: MI0000062,

ENA: LM608151.1:1..74:precursor_RNA,

URS0000699FB5_9606 pre_miRNA 79 1

Rfam: RF00027,

URS0001BC7430_9606 pre_miRNA 79 1

Rfam: RF00027,

MIRLET7A3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7A3 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A3 Gene

No ASD Table

Relevant External Links for MIRLET7A3 Gene

GeneLoc Exon Structure for
MIRLET7A3

Expression for MIRLET7A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIRLET7A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7A3

genes like me logo Genes that share expression patterns with MIRLET7A3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A3 Gene

Orthologs for MIRLET7A3 Gene

Evolution for MIRLET7A3 Gene

ENSEMBL:
Gene Tree for MIRLET7A3 (if available)
TreeFam:
Gene Tree for MIRLET7A3 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7A3

No data available for Orthologs for MIRLET7A3 Gene

Paralogs for MIRLET7A3 Gene

No data available for Paralogs for MIRLET7A3 Gene

Variants for MIRLET7A3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A3 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
nsv1152661 OTHER inversion 26484159
nsv459905 CNV loss 19166990
nsv471212 CNV loss 18288195
nsv471213 CNV gain 18288195
nsv516279 CNV loss 19592680
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv834224 CNV loss 17160897

Additional Variant Information for MIRLET7A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A3
Leiden Open Variation Database (LOVD)
MIRLET7A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7A3 Gene

Disorders for MIRLET7A3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIRLET7A3 Gene - From: MID and GCD

Disorder Aliases PubMed IDs
ovarian epithelial cancer
  • eoc
acute promyelocytic leukemia
  • apl
lung cancer
  • lung cancer, susceptibility to
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7A3

genes like me logo Genes that share disorders with MIRLET7A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A3 Gene

Publications for MIRLET7A3 Gene

  1. Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis. (PMID: 17974952) Lu L … Yu H (Cancer research 2007) 3 72
  2. Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. (PMID: 32208417) Fadhil RS … Nair RG (PloS one 2020) 3
  3. Let-7a-5p represses proliferation, migration, invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells. (PMID: 32345785) Liu H … Jiang B (Journal of biosciences 2020) 3
  4. Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor. (PMID: 31330067) Singh A … Eswarappa SM (The EMBO journal 2019) 3
  5. Inhibition effect of exosomes-mediated Let-7a on the development and metastasis of triple negative breast cancer by down-regulating the expression of c-Myc. (PMID: 31298382) Du J … Ma BL (European review for medical and pharmacological sciences 2019) 3

Products for MIRLET7A3 Gene

Sources for MIRLET7A3 Gene