Aliases for MIRLET7A2 Gene
Subcategory (RNA class) for MIRLET7A2 Gene
miRNA
Quality Score for this RNA gene is
18.2
External Ids for MIRLET7A2 Gene
- HGNC: 31477
- Entrez Gene: 406882
- Ensembl: ENSG00000198975
- OMIM: 612142
- miRBase: hsa-let-7a-2
ORGUL Members for MIRLET7A2 Gene
Previous HGNC Symbols for MIRLET7A2 Gene
- MIRNLET7A2
Previous GeneCards Identifiers for MIRLET7A2 Gene
- GC11M121525
- GC11M122017
Summaries for MIRLET7A2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIRLET7A2 Gene
MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A2 include Hepatocellular Carcinoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
fRNAdb sequence ontologies for MIRLET7A2 Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIRLET7A2 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene
Genomics for MIRLET7A2 Gene
GeneHancer (GH) Regulatory Elements for MIRLET7A2 Gene
Promoters and enhancers for MIRLET7A2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J122144 | Enhancer | 0.7 | ENCODE dbSUPER | 650.7 | -0.2 | -229 | 3.9 | JUND USF1 JUN USF2 FOSL2 EP300 | MIRLET7A2 BLID MIR100HG GC11M122153 | |
| GH11J122185 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 11.3 | -45.6 | -45631 | 13.3 | FOXA2 SIN3A BATF RAD21 RFX5 ZNF143 RCOR1 FOS RXRA JUNB | GC11M122182 MIRLET7A2 BLID MIR100HG ENSG00000255219 GC11P122184 GC11P122197 | |
| GH11J122150 | Enhancer | 0.9 | ENCODE dbSUPER | 0.7 | -4.9 | -4947 | 2.4 | FOXA2 ZNF792 TEAD3 RERE FOSL2 TCF7L2 HMG20B TEAD1 HLF FOXA3 | GC11M122153 GC11M122154 GC11M122156 MIR100 BLID MIR100HG MIRLET7A2 | |
| GH11J122135 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 0.4 | +7.7 | 7716 | 7.3 | FOXA2 JUN BRCA1 YY1 ETS1 GATA3 RERE POLR2A HNF4G FOSL2 | BLID MIR100HG MIRLET7A2 GC11P122118 | |
| GH11J122149 | Enhancer | 0.4 | ENCODE dbSUPER | 0.7 | -2.8 | -2835 | 0.2 | BLID MIR100HG GC11M122153 MIRLET7A2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIRLET7A2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIRLET7A2 Gene
Genomic Locations for MIRLET7A2 Gene
- chr11:122,146,522-122,146,593
- (GRCh38/hg38)
- Size:
- 72 bases
- Orientation:
- Minus strand
- chr11:122,017,229-122,017,301
- (GRCh37/hg19)
- Size:
- 73 bases
- Orientation:
- Minus strand
Genomic View for MIRLET7A2 Gene
Genes around MIRLET7A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.1 by Entrez Gene
- 11q24.1 by HGNC
- 11q24.1 by Ensembl
MIRLET7A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIRLET7A2 Gene
ORGUL Member Location for MIRLET7A2 Gene
Proteins for MIRLET7A2 Gene
Post-translational modifications for MIRLET7A2 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIRLET7A2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7A2
- Origene Custom Protein Services for MIRLET7A2
- Search GeneTex for Proteins for MIRLET7A2
No data available for DME Specific Peptides for MIRLET7A2 Gene
Domains & Families for MIRLET7A2 Gene
Gene Families for MIRLET7A2 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A2 Gene
Function for MIRLET7A2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
- Browse CRISPR knockouts for MIRLET7A2
- Applied Biological Materials CRISPR for MIRLET7A2
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIRLET7A2
- Applied Biological Materials Clones for MIRLET7A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A2 Gene
Localization for MIRLET7A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 18766170 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A2 Gene
Pathways & Interactions for MIRLET7A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
Pathways by source for MIRLET7A2 Gene
1 BioSystems pathway for MIRLET7A2 Gene
1 KEGG pathway for MIRLET7A2 Gene
Interacting Proteins for MIRLET7A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 17671087 |
| GO:0098806 | deadenylation involved in gene silencing by miRNA | IMP | 17671087 |
No data available for SIGNOR curated interactions for MIRLET7A2 Gene
Transcripts for MIRLET7A2 Gene
fRNAdb Secondary structures for MIRLET7A2 Gene
mRNA/cDNA for MIRLET7A2 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000362105 72 bps (uc001pyg.4)
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIRLET7A2
- Applied Biological Materials CRISPR for MIRLET7A2
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIRLET7A2
- Applied Biological Materials Clones for MIRLET7A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIRLET7A2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A2 Gene:
MIRLET7A2
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A2 Gene
Orthologs for MIRLET7A2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7a-2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-let-7a-2 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7a-2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-let-7a-2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mirlet7a-2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-let-7a-2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-let-7a-2 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | csa-let-7c-1 34 |
|
OneToMany |
- Species where no ortholog for MIRLET7A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIRLET7A2 Gene
No data available for Paralogs for MIRLET7A2 Gene
Variants for MIRLET7A2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000060316 | -- | 122,147,981(-) | T/G | upstream_transcript_variant | |
| rs1000351087 | -- | 122,146,233(-) | TTTTTTT/TTTTTT | downstream_transcript_variant | |
| rs1000670979 | -- | 122,146,444(-) | C/A | downstream_transcript_variant | |
| rs1000989418 | -- | 122,147,905(-) | A/G | upstream_transcript_variant | |
| rs1003176772 | -- | 122,148,445(-) | A/C | upstream_transcript_variant |
Additional Variant Information for MIRLET7A2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A2 Gene
Disorders for MIRLET7A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
| lung cancer |
|
Search MIRLET7A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIRLET7A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A2 Gene
Publications for MIRLET7A2 Gene
- Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
- A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. (PMID: 27066911) Tran ND … Blelloch RH (Stem cells (Dayton, Ohio) 2016) 3 58
- Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. (PMID: 27693636) Deng M … Meng S (Cancer letters 2016) 3 58
- Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells. (PMID: 25515921) Song H … Zheng JN (Oncology reports 2015) 3 58
- Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. (PMID: 25647078) Iwasaki T … Tsumura H (International journal of oncology 2015) 3 58
Products for MIRLET7A2 Gene
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Sources for MIRLET7A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt