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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A2 include Oral Squamous Cell Carcinoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J122185 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 11.3 | -45.7 | -45690 | 13.4 | REST CEBPB SP1 JUND ATF3 NR3C1 FOS CHD2 FOXA2 JUN | MIRLET7A2 BLID MIR100HG ENSG00000255219 piR-41306-051 lnc-UBASH3B-5 lnc-UBASH3B-6 lnc-UBASH3B-2 UBASH3B | |
GH11J122144 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.7 | -2.2 | -2178 | 7.9 | ATF7 REST TCF7 SP1 TCF7L2 FOXA2 JUN USF1 TEAD1 ATF2 | BLID MIR100HG MIR100 MIR10526 MIRLET7A2 RF00104-008 ENSG00000255219 UBASH3B | |
GH11J122145 | Enhancer | 0.3 | Ensembl dbSUPER | 0.7 | +2.1 | 2094 | 0.2 | BLID MIR100HG ENSG00000255219 MIRLET7A2 UBASH3B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19878981 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 18766170 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Metastatic brain tumor |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 17671087 |
GO:0070104 | negative regulation of interleukin-6-mediated signaling pathway | IDA | 19878981 |
GO:0098806 | deadenylation involved in gene silencing by miRNA | IMP | 17671087 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000157F5_9606 | miRNA | 22 | 6 |
RefSeq: NR_029477, LncBase: hsa-let-7a-2-3p, miRBase: MIMAT0010195, MirGeneDB: Hsa-Let-7-P1a_3p, TarBase: hsa-let-7a-2-3p, ENA: AY940858.1:1..22:ncRNA, LM381217.1:1..22:ncRNA, LM608150.1:50..71:ncRNA, |
URS0000416056_9606 | miRNA | 22 | 6 |
RefSeq: NR_029476, NR_029477, NR_029478, LncBase: hsa-let-7a-5p, miRBase: MIMAT0000062, MirGeneDB: Hsa-Let-7-P1a_5p, Hsa-Let-7-P2a1_5p, Hsa-Let-7-P2a2_5p, TarBase: hsa-let-7a-5p, ENA: View 8 records in RNAcentral |
URS00003F0B88_9606 | precursor_RNA | 72 | 5 |
HGNC: 31477, RefSeq: NR_029477, Ensembl: ENST00000362105 (view in UCSC) , miRBase: MI0000061, |
URS0000475C77_9606 | precursor_RNA | 76 | 1 |
Rfam: RF00027, |
URS0000EFEF97_9606 | precursor_RNA | 68 | 1 |
MirGeneDB: Hsa-Let-7-P1a, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7a-2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-let-7a-2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7a-2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-let-7a-2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mirlet7a-2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-let-7a-2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-let-7a-2 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-let-7c-1 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
oral squamous cell carcinoma |
|
|
lung cancer |
|
|
hepatocellular carcinoma |
|