microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7A2 Gene

Data sources for MIRLET7A2 Gene:

RNA type for MIRLET7A2 Gene

miRNA

Aliases for MIRLET7A2 Gene

External Ids for MIRLET7A2 Gene

Previous HGNC Symbols for MIRLET7A2 Gene

  • MIRNLET7A2

Previous GeneCards Identifiers for MIRLET7A2 Gene

  • GC11M121525
  • GC11M122017

Summaries for MIRLET7A2 Gene

Entrez Gene Summary for MIRLET7A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A2 Gene

MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A2 include Oral Squamous Cell Carcinoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIRLET7A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene

Genomics for MIRLET7A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIRLET7A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122145 Enhancer 0.8 Ensembl ENCODE dbSUPER 250.7 -0.6 -606 5.6 ATF2 EP300 JUND USF2 ATF7 USF1 MIRLET7A2 BLID MIR100HG MIR10526 ENSG00000255219 UBASH3B
GH11J122185 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -45.8 -45788 13.6 JUND BCL11A CEBPB MAX EP300 FOXA2 PRDM1 MAFF RXRA RAD21 MIRLET7A2 BLID MIR100HG ENSG00000255219 piR-41306-051 lnc-UBASH3B-5 lnc-UBASH3B-6 lnc-UBASH3B-2 UBASH3B
GH11J122150 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.7 -4.9 -4878 2.5 FOXA2 TEAD3 HMG20A HMG20B ZNF792 HNF4A ARID3A HLF TCF7 RERE MIR100 MIR10526 RF00104-008 BLID MIR100HG MIRLET7A2 ENSG00000255219 UBASH3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIRLET7A2 Gene

Latest Assembly
chr11:122,146,520-122,146,595
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand

Previous Assembly
chr11:122,017,230-122,017,301
(GRCh37/hg19 by Entrez Gene)
Size:
72 bases
Orientation:
Minus strand

chr11:122,017,229-122,017,301
(GRCh37/hg19 by Ensembl)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIRLET7A2 Gene

Genes around MIRLET7A2 on UCSC Golden Path with GeneCards custom track
MIRLET7A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIRLET7A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A2 Gene

Proteins for MIRLET7A2 Gene

Post-translational modifications for MIRLET7A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A2 Gene

Domains & Families for MIRLET7A2 Gene

Gene Families for MIRLET7A2 Gene

genes like me logo Genes that share domains with MIRLET7A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7A2 Gene

Function for MIRLET7A2 Gene

Phenotypes From GWAS Catalog for MIRLET7A2 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIRLET7A2: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A2 Gene

Localization for MIRLET7A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIRLET7A2 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:0070062 extracellular exosome IDA --
GO:1903561 extracellular vesicle HDA --
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A2 Gene

Pathways & Interactions for MIRLET7A2 Gene

PathCards logo

SuperPathways for MIRLET7A2 Gene

genes like me logo Genes that share pathways with MIRLET7A2: view

Pathways by source for MIRLET7A2 Gene

1 BioSystems pathway for MIRLET7A2 Gene
1 KEGG pathway for MIRLET7A2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA --
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA --
GO:0098806 deadenylation involved in gene silencing by miRNA IMP --
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7A2 Gene

Drugs & Compounds for MIRLET7A2 Gene

No Compound Related Data Available

Transcripts for MIRLET7A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7A2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000157F5_9606 miRNA 22 6

RefSeq: NR_029477,

LncBase: hsa-let-7a-2-3p,

miRBase: MIMAT0010195,

MirGeneDB: Hsa-Let-7-P1a_3p,

TarBase: hsa-let-7a-2-3p,

ENA: AY940858.1:1..22:ncRNA, LM381217.1:1..22:ncRNA, LM608150.1:50..71:ncRNA,

URS0000416056_9606 miRNA 22 6

RefSeq: NR_029476, NR_029477, NR_029478,

LncBase: hsa-let-7a-5p,

miRBase: MIMAT0000062,

MirGeneDB: Hsa-Let-7-P1a_5p, Hsa-Let-7-P2a1_5p, Hsa-Let-7-P2a2_5p,

TarBase: hsa-let-7a-5p,

ENA: View 8 records in RNAcentral

URS00003F0B88_9606 pre_miRNA 72 4

RefSeq: NR_029477,

Ensembl: ENST00000362105 (view in UCSC) ,

miRBase: MI0000061,

ENA: LM608150.1:1..72:precursor_RNA,

URS0000475C77_9606 pre_miRNA 76 1

Rfam: RF00027,

URS0001BC2BFD_9606 pre_miRNA 76 1

Rfam: RF00027,

MIRLET7A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIRLET7A2 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A2 Gene

No ASD Table

Relevant External Links for MIRLET7A2 Gene

GeneLoc Exon Structure for
MIRLET7A2

Expression for MIRLET7A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7A2

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A2 Gene

Orthologs for MIRLET7A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7a-2 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-let-7a-2 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-let-7a-2 30
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 69 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-let-7a-2 30
  • 68 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mirlet7a-2 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-let-7a-2 30
  • 92 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 77 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-2 30
  • 80 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 30
  • 42 (a)
OneToMany
Species where no ortholog for MIRLET7A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIRLET7A2 Gene

ENSEMBL:
Gene Tree for MIRLET7A2 (if available)
TreeFam:
Gene Tree for MIRLET7A2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIRLET7A2

Paralogs for MIRLET7A2 Gene

No data available for Paralogs for MIRLET7A2 Gene

Variants for MIRLET7A2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIRLET7A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A2 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897
esv275465 CNV gain+loss 21479260

Additional Variant Information for MIRLET7A2 Gene

Human Gene Mutation Database (HGMD)
MIRLET7A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A2
Leiden Open Variation Database (LOVD)
MIRLET7A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7A2 Gene

Disorders for MIRLET7A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIRLET7A2 Gene - From: MID and COP

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
lung cancer
  • lung cancer, susceptibility to
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7A2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIRLET7A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A2 Gene

Publications for MIRLET7A2 Gene

  1. Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. (PMID: 32208417) Fadhil RS … Nair RG (PloS one 2020) 3
  2. Let-7a-5p represses proliferation, migration, invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells. (PMID: 32345785) Liu H … Jiang B (Journal of biosciences 2020) 3
  3. Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor. (PMID: 31330067) Singh A … Eswarappa SM (The EMBO journal 2019) 3
  4. Inhibition effect of exosomes-mediated Let-7a on the development and metastasis of triple negative breast cancer by down-regulating the expression of c-Myc. (PMID: 31298382) Du J … Ma BL (European review for medical and pharmacological sciences 2019) 3
  5. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. (PMID: 29748571) Ottaviani S … Castellano L (Nature communications 2018) 3

Products for MIRLET7A2 Gene

Sources for MIRLET7A2 Gene