Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIRLET7A2 Gene

Subcategory (RNA class) for MIRLET7A2 Gene

miRNA

Quality Score for this RNA gene is

18.2

Aliases for MIRLET7A2 Gene

  • MicroRNA Let-7a-2 2 3 5
  • Hsa-Let-7a-2 3
  • MIRNLET7A2 3
  • Let-7a-2 3
  • LET7A2 3

External Ids for MIRLET7A2 Gene

Previous HGNC Symbols for MIRLET7A2 Gene

  • MIRNLET7A2

Previous GeneCards Identifiers for MIRLET7A2 Gene

  • GC11M121525
  • GC11M122017

Summaries for MIRLET7A2 Gene

Entrez Gene Summary for MIRLET7A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A2 Gene

MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A2 include Hepatocellular Carcinoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

fRNAdb sequence ontologies for MIRLET7A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIRLET7A2

Additional gene information for MIRLET7A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene

Genomics for MIRLET7A2 Gene

GeneHancer (GH) Regulatory Elements for MIRLET7A2 Gene

Promoters and enhancers for MIRLET7A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122144 Enhancer 0.7 ENCODE dbSUPER 650.7 -0.2 -229 3.9 JUND USF1 JUN USF2 FOSL2 EP300 MIRLET7A2 BLID MIR100HG GC11M122153
GH11J122185 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -45.6 -45631 13.3 FOXA2 SIN3A BATF RAD21 RFX5 ZNF143 RCOR1 FOS RXRA JUNB GC11M122182 MIRLET7A2 BLID MIR100HG ENSG00000255219 GC11P122184 GC11P122197
GH11J122150 Enhancer 0.9 ENCODE dbSUPER 0.7 -4.9 -4947 2.4 FOXA2 ZNF792 TEAD3 RERE FOSL2 TCF7L2 HMG20B TEAD1 HLF FOXA3 GC11M122153 GC11M122154 GC11M122156 MIR100 BLID MIR100HG MIRLET7A2
GH11J122135 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +7.7 7716 7.3 FOXA2 JUN BRCA1 YY1 ETS1 GATA3 RERE POLR2A HNF4G FOSL2 BLID MIR100HG MIRLET7A2 GC11P122118
GH11J122149 Enhancer 0.4 ENCODE dbSUPER 0.7 -2.8 -2835 0.2 BLID MIR100HG GC11M122153 MIRLET7A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7A2 Gene

Genomic Locations for MIRLET7A2 Gene
chr11:122,146,522-122,146,593
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chr11:122,017,229-122,017,301
(GRCh37/hg19)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIRLET7A2 Gene

Genes around MIRLET7A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 Gene

ORGUL Member Location for MIRLET7A2 gene

Proteins for MIRLET7A2 Gene

Post-translational modifications for MIRLET7A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A2 Gene

Domains & Families for MIRLET7A2 Gene

Gene Families for MIRLET7A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIRLET7A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIRLET7A2 Gene

Function for MIRLET7A2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A2 Gene

Localization for MIRLET7A2 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A2 Gene

Pathways & Interactions for MIRLET7A2 Gene

genes like me logo Genes that share pathways with MIRLET7A2: view

Pathways by source for MIRLET7A2 Gene

1 BioSystems pathway for MIRLET7A2 Gene
1 KEGG pathway for MIRLET7A2 Gene

Interacting Proteins for MIRLET7A2 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 17671087
GO:0098806 deadenylation involved in gene silencing by miRNA IMP 17671087
genes like me logo Genes that share ontologies with MIRLET7A2: view

No data available for SIGNOR curated interactions for MIRLET7A2 Gene

Drugs & Compounds for MIRLET7A2 Gene

No Compound Related Data Available

Transcripts for MIRLET7A2 Gene

fRNAdb Secondary structures for MIRLET7A2 Gene

  • hsa-let-7a-2_MI0000061_Homo_sapiens_let-7a-2_stem-loop_hairpin

mRNA/cDNA for MIRLET7A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A2 Gene

No ASD Table

Relevant External Links for MIRLET7A2 Gene

GeneLoc Exon Structure for
MIRLET7A2
ECgene alternative splicing isoforms for
MIRLET7A2

Expression for MIRLET7A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A2 Gene:

MIRLET7A2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A2 Gene

Orthologs for MIRLET7A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7a-2 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7a-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7a-2 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-let-7a-2 34
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mirlet7a-2 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-let-7a-2 34
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-2 34
  • 80 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-let-7c-1 34
  • 42 (a)
OneToMany
Species where no ortholog for MIRLET7A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7A2 Gene

ENSEMBL:
Gene Tree for MIRLET7A2 (if available)
TreeFam:
Gene Tree for MIRLET7A2 (if available)

Paralogs for MIRLET7A2 Gene

No data available for Paralogs for MIRLET7A2 Gene

Variants for MIRLET7A2 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000060316 -- 122,147,981(-) T/G upstream_transcript_variant
rs1000351087 -- 122,146,233(-) TTTTTTT/TTTTTT downstream_transcript_variant
rs1000670979 -- 122,146,444(-) C/A downstream_transcript_variant
rs1000989418 -- 122,147,905(-) A/G upstream_transcript_variant
rs1003176772 -- 122,148,445(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A2 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897
esv275465 CNV gain+loss 21479260

Additional Variant Information for MIRLET7A2 Gene

Human Gene Mutation Database (HGMD)
MIRLET7A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A2 Gene

Disorders for MIRLET7A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIRLET7A2 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIRLET7A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A2 Gene

Publications for MIRLET7A2 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  2. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. (PMID: 27066911) Tran ND … Blelloch RH (Stem cells (Dayton, Ohio) 2016) 3 58
  3. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. (PMID: 27693636) Deng M … Meng S (Cancer letters 2016) 3 58
  4. Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells. (PMID: 25515921) Song H … Zheng JN (Oncology reports 2015) 3 58
  5. Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. (PMID: 25647078) Iwasaki T … Tsumura H (International journal of oncology 2015) 3 58

Products for MIRLET7A2 Gene

Sources for MIRLET7A2 Gene

Content
Loading form....