Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIRLET7A2 Gene
Subcategory (RNA class) for MIRLET7A2 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIRLET7A2 Gene
External Ids for MIRLET7A2 Gene
- HGNC: 31477
- Entrez Gene: 406882
- Ensembl: ENSG00000198975
- OMIM: 612142
- miRBase: hsa-let-7a-2
Previous HGNC Symbols for MIRLET7A2 Gene
- MIRNLET7A2
Previous GeneCards Identifiers for MIRLET7A2 Gene
- GC11M121525
- GC11M122017
Summaries for MIRLET7A2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIRLET7A2 Gene
MIRLET7A2 (MicroRNA Let-7a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A2 include Oral Squamous Cell Carcinoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
Rfam classification for MIRLET7A2 Gene
-
let-7 microRNA precursor
Additional gene information for MIRLET7A2 Gene
- HGNC(31477)
- Entrez Gene(406882)
- Ensembl(ENSG00000198975)
- OMIM(612142)
- Open Targets Platform(ENSG00000198975)
- Search for MIRLET7A2 at DataMed
- Search for MIRLET7A2 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A2 Gene
Genomics for MIRLET7A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIRLET7A2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J122185 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 11.3 | -45.7 | -45690 | 13.4 | REST CEBPB SP1 JUND ATF3 NR3C1 FOS CHD2 FOXA2 JUN | MIRLET7A2 BLID MIR100HG ENSG00000255219 piR-41306-051 lnc-UBASH3B-5 lnc-UBASH3B-6 lnc-UBASH3B-2 UBASH3B | |
| GH11J122144 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.7 | -2.2 | -2178 | 7.9 | ATF7 REST TCF7 SP1 TCF7L2 FOXA2 JUN USF1 TEAD1 ATF2 | BLID MIR100HG MIR100 MIR10526 MIRLET7A2 RF00104-008 ENSG00000255219 UBASH3B | |
| GH11J122145 | Enhancer | 0.3 | Ensembl dbSUPER | 0.7 | +2.1 | 2094 | 0.2 | BLID MIR100HG ENSG00000255219 MIRLET7A2 UBASH3B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIRLET7A2 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIRLET7A2 Gene
Genomic Locations for MIRLET7A2 Gene
- chr11:122,146,520-122,146,595
- (GRCh38/hg38)
- Size:
- 76 bases
- Orientation:
- Minus strand
- chr11:122,017,229-122,017,301
- (GRCh37/hg19)
- Size:
- 73 bases
- Orientation:
- Minus strand
Genomic View for MIRLET7A2 Gene
Genes around MIRLET7A2 on UCSC Golden Path with GeneCards custom track
MIRLET7A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q24.1 by HGNC
- 11q24.1 by Entrez Gene
- 11q24.1 by Ensembl
MIRLET7A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIRLET7A2 Gene
Proteins for MIRLET7A2 Gene
Post-translational modifications for MIRLET7A2 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7A2
- Origene Custom Protein Services for MIRLET7A2
No data available for DME Specific Peptides for MIRLET7A2 Gene
Domains & Families for MIRLET7A2 Gene
Gene Families for MIRLET7A2 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7A2 Gene
Function for MIRLET7A2 Gene
Phenotypes From GWAS Catalog for MIRLET7A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19878981 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7A2 - Select products 50% OFF >
- * MIRLET7A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIRLET7A2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7A2 - Select products 50% OFF >
- * MIRLET7A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A2 Gene
Localization for MIRLET7A2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 18766170 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A2 Gene
Pathways & Interactions for MIRLET7A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
Pathways by source for MIRLET7A2 Gene
1 BioSystems pathway for MIRLET7A2 Gene
1 KEGG pathway for MIRLET7A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 17671087 |
| GO:0070104 | negative regulation of interleukin-6-mediated signaling pathway | IDA | 19878981 |
| GO:0098806 | deadenylation involved in gene silencing by miRNA | IMP | 17671087 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIRLET7A2 Gene
Transcripts for MIRLET7A2 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIRLET7A2 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00000157F5_9606 | miRNA | 22 | 6 |
RefSeq: NR_029477, LncBase: hsa-let-7a-2-3p, miRBase: MIMAT0010195, MirGeneDB: Hsa-Let-7-P1a_3p, TarBase: hsa-let-7a-2-3p, ENA: AY940858.1:1..22:ncRNA, LM381217.1:1..22:ncRNA, LM608150.1:50..71:ncRNA, |
| URS0000416056_9606 | miRNA | 22 | 6 |
RefSeq: NR_029476, NR_029477, NR_029478, LncBase: hsa-let-7a-5p, miRBase: MIMAT0000062, MirGeneDB: Hsa-Let-7-P1a_5p, Hsa-Let-7-P2a1_5p, Hsa-Let-7-P2a2_5p, TarBase: hsa-let-7a-5p, ENA: View 8 records in RNAcentral |
| URS00003F0B88_9606 | precursor_RNA | 72 | 5 |
HGNC: 31477, RefSeq: NR_029477, Ensembl: ENST00000362105 (view in UCSC) , miRBase: MI0000061, |
| URS0000475C77_9606 | precursor_RNA | 76 | 1 |
Rfam: RF00027, |
| URS0000EFEF97_9606 | precursor_RNA | 68 | 1 |
MirGeneDB: Hsa-Let-7-P1a, |
MIRLET7A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIRLET7A2 Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7A2 - Select products 50% OFF >
- * MIRLET7A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIRLET7A2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7A2 - Select products 50% OFF >
- * MIRLET7A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIRLET7A2 Gene
- GeneLoc Exon Structure for
- MIRLET7A2
Expression for MIRLET7A2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIRLET7A2
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIRLET7A2
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A2 Gene
Orthologs for MIRLET7A2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7a-2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-let-7a-2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7a-2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-let-7a-2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mirlet7a-2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-let-7a-2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-let-7a-2 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-let-7c-1 31 |
|
OneToMany |
- Species where no ortholog for MIRLET7A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIRLET7A2 Gene
No data available for Paralogs for MIRLET7A2 Gene
Variants for MIRLET7A2 Gene
Additional Variant Information for MIRLET7A2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIRLET7A2 Gene
Disorders for MIRLET7A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oral squamous cell carcinoma |
|
|
| lung cancer |
|
|
| hepatocellular carcinoma |
|
Search MIRLET7A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIRLET7A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A2 Gene
Publications for MIRLET7A2 Gene
- Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. (PMID: 32208417) Fadhil RS … Nair RG (PloS one 2020) 3
- Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor. (PMID: 31330067) Singh A … Eswarappa SM (The EMBO journal 2019) 3
- TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. (PMID: 29748571) Ottaviani S … Castellano L (Nature communications 2018) 3
- Downregulation of exosomal let-7a-5p in dust exposed- workers contributes to lung cancer development. (PMID: 30497474) Zhang L … Yao W (Respiratory research 2018) 3
- A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3
Products for MIRLET7A2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7A2
- Origene Custom Protein Services for MIRLET7A2
- Browse OriGene Inhibitory RNA Products For MIRLET7A2
- OriGene qPCR primer pairs for MIRLET7A2
- Browse CRISPR knockouts for MIRLET7A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIRLET7A2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIRLET7A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIRLET7A2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIRLET7A2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIRLET7A2
Sources for MIRLET7A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB