microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIRLET7A1 Gene

Subcategory (RNA class) for MIRLET7A1 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIRLET7A1 Gene

  • MicroRNA Let-7a-1 2 3 5
  • Hsa-Let-7a-5p 168 179
  • Hsa-Let-7a-3p 168 179
  • Hsa-Let-7a-1 3
  • MIMAT0004481 53
  • MIMAT0000062 53
  • MIRNLET7A1 3
  • MI0000060 53
  • MIRLET7A1 2
  • Let-7a-1 3
  • RF00027 174
  • LET7A1 3

External Ids for MIRLET7A1 Gene

Previous HGNC Symbols for MIRLET7A1 Gene

  • MIRNLET7A1

Previous GeneCards Identifiers for MIRLET7A1 Gene

  • GC09P095981
  • GC09P096938

Summaries for MIRLET7A1 Gene

Entrez Gene Summary for MIRLET7A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIRLET7A1 Gene

MIRLET7A1 (MicroRNA Let-7a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A1 include Colorectal Cancer and Pituitary Adenoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.

Rfam classification for MIRLET7A1 Gene

Additional gene information for MIRLET7A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A1 Gene

Genomics for MIRLET7A1 Gene

GeneHancer (GH) Regulatory Elements for MIRLET7A1 Gene

Promoters and enhancers for MIRLET7A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIRLET7A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIRLET7A1 Gene

Genomic Locations for MIRLET7A1 Gene
chr9:94,175,956-94,176,037
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr9:96,938,234-96,938,325
(GRCh37/hg19)
Size:
92 bases
Orientation:
Plus strand

Genomic View for MIRLET7A1 Gene

Genes around MIRLET7A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIRLET7A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIRLET7A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIRLET7A1 Gene

Proteins for MIRLET7A1 Gene

Post-translational modifications for MIRLET7A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIRLET7A1 Gene

Domains & Families for MIRLET7A1 Gene

Gene Families for MIRLET7A1 Gene

genes like me logo Genes that share domains with MIRLET7A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7A1 Gene

Function for MIRLET7A1 Gene

Phenotypes From GWAS Catalog for MIRLET7A1 Gene

Gene Ontology (GO) - Molecular Function for MIRLET7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19878981
genes like me logo Genes that share ontologies with MIRLET7A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A1 Gene

Localization for MIRLET7A1 Gene

Gene Ontology (GO) - Cellular Components for MIRLET7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIRLET7A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A1 Gene

Pathways & Interactions for MIRLET7A1 Gene

genes like me logo Genes that share pathways with MIRLET7A1: view

Pathways by source for MIRLET7A1 Gene

2 BioSystems pathways for MIRLET7A1 Gene
1 KEGG pathway for MIRLET7A1 Gene

Gene Ontology (GO) - Biological Process for MIRLET7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 17671087
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA 19878981
GO:0098806 deadenylation involved in gene silencing by miRNA IMP 17671087
genes like me logo Genes that share ontologies with MIRLET7A1: view

No data available for SIGNOR curated interactions for MIRLET7A1 Gene

Drugs & Compounds for MIRLET7A1 Gene

No Compound Related Data Available

Transcripts for MIRLET7A1 Gene

mRNA/cDNA for MIRLET7A1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(12) ENA transcripts :
(2) LncBase transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :
(3) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIRLET7A1 Gene

No ASD Table

Relevant External Links for MIRLET7A1 Gene

GeneLoc Exon Structure for
MIRLET7A1
ECgene alternative splicing isoforms for
MIRLET7A1

Expression for MIRLET7A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIRLET7A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A1 Gene:

MIRLET7A1
genes like me logo Genes that share expression patterns with MIRLET7A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A1 Gene

Orthologs for MIRLET7A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIRLET7A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-let-7a-1 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-let-7a-1 33
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 89 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-let-7a-1 33
  • 86 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mirlet7a-1 33
  • 80 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-let-7k 33
  • 75 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-let-7a 33
  • 91 (a)
ManyToMany
-- 33
  • 76 (a)
ManyToMany
aca-let-7e 33
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-let-7a-3 33
  • 67 (a)
ManyToMany
CR354430.2 33
  • 67 (a)
ManyToMany
dre-let-7e 33
  • 62 (a)
ManyToMany
Species where no ortholog for MIRLET7A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIRLET7A1 Gene

ENSEMBL:
Gene Tree for MIRLET7A1 (if available)
TreeFam:
Gene Tree for MIRLET7A1 (if available)

Paralogs for MIRLET7A1 Gene

No data available for Paralogs for MIRLET7A1 Gene

Variants for MIRLET7A1 Gene

Sequence variations from dbSNP and Humsavar for MIRLET7A1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001069410 -- 94,174,436(+) C/T upstream_transcript_variant
rs1001242486 -- 94,174,454(+) G/A upstream_transcript_variant
rs1001589170 -- 94,174,757(+) C/T upstream_transcript_variant
rs1002261112 -- 94,176,065(+) G/T downstream_transcript_variant
rs1002305969 -- 94,175,091(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIRLET7A1 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV gain 17160897

Additional Variant Information for MIRLET7A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIRLET7A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A1 Gene

Disorders for MIRLET7A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIRLET7A1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
pituitary adenoma
  • adenoma of the pituitary gland
hepatocellular carcinoma
  • hcc
reproductive system disease
  • genital system disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIRLET7A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIRLET7A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A1 Gene

Publications for MIRLET7A1 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 43 56
  2. H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7. (PMID: 29523225) Kou N … Liu H (Oncology research 2019) 3 56
  3. Tumor suppressor let-7a inhibits breast cancer cell proliferation, migration and invasion by targeting MAGE-A1. (PMID: 30509089) Mi Y … Geng C (Neoplasma 2019) 3 56
  4. ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer. (PMID: 30279206) Zhang Z … Duan W (Bioscience reports 2018) 3 56
  5. Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1. (PMID: 30066899) Zhao W … Xie SY (Oncology reports 2018) 3 56

Products for MIRLET7A1 Gene

Sources for MIRLET7A1 Gene