microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIRLET7A1 Gene
Subcategory (RNA class) for MIRLET7A1 Gene
miRNA
Quality Score for this RNA gene is
17
Aliases for MIRLET7A1 Gene
External Ids for MIRLET7A1 Gene
- HGNC: 31476
- Entrez Gene: 406881
- Ensembl: ENSG00000199165
- OMIM: 605386
- miRBase: hsa-let-7a-1
Previous HGNC Symbols for MIRLET7A1 Gene
- MIRNLET7A1
Previous GeneCards Identifiers for MIRLET7A1 Gene
- GC09P095981
- GC09P096938
Summaries for MIRLET7A1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIRLET7A1 Gene
MIRLET7A1 (MicroRNA Let-7a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A1 include Colorectal Cancer and Pituitary Adenoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.
Rfam classification for MIRLET7A1 Gene
-
let-7 microRNA precursor
Additional gene information for MIRLET7A1 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIRLET7A1 Gene
Genomics for MIRLET7A1 Gene
GeneHancer (GH) Regulatory Elements for MIRLET7A1 Gene
Promoters and enhancers for MIRLET7A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIRLET7A1 on UCSC Golden Path with GeneCards custom track
Genomic Locations for MIRLET7A1 Gene
Genomic Locations for MIRLET7A1 Gene
- chr9:94,175,956-94,176,037
- (GRCh38/hg38)
- Size:
- 82 bases
- Orientation:
- Plus strand
- chr9:96,938,234-96,938,325
- (GRCh37/hg19)
- Size:
- 92 bases
- Orientation:
- Plus strand
Genomic View for MIRLET7A1 Gene
Genes around MIRLET7A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.32 by HGNC
- 9q22.32 by Entrez Gene
- 9q22.32 by Ensembl
MIRLET7A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIRLET7A1 Gene
Proteins for MIRLET7A1 Gene
Post-translational modifications for MIRLET7A1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIRLET7A1
- Origene Custom Protein Services for MIRLET7A1
No data available for DME Specific Peptides for MIRLET7A1 Gene
Domains & Families for MIRLET7A1 Gene
Gene Families for MIRLET7A1 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIRLET7A1 Gene
Function for MIRLET7A1 Gene
Phenotypes From GWAS Catalog for MIRLET7A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19878981 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7A1 - Select products 50% OFF >
- * MIRLET7A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIRLET7A1 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIRLET7A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7A1 - Select products 50% OFF >
- * MIRLET7A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIRLET7A1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Addgene plasmids for MIRLET7A1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIRLET7A1 Gene
Localization for MIRLET7A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 18766170 |
| GO:0016442 | RISC complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIRLET7A1 Gene
Pathways & Interactions for MIRLET7A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
| 3 | miRNAs involved in DNA damage response | ||
Pathways by source for MIRLET7A1 Gene
2 BioSystems pathways for MIRLET7A1 Gene
1 KEGG pathway for MIRLET7A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 17671087 |
| GO:0070104 | negative regulation of interleukin-6-mediated signaling pathway | IDA | 19878981 |
| GO:0098806 | deadenylation involved in gene silencing by miRNA | IMP | 17671087 |
No data available for SIGNOR curated interactions for MIRLET7A1 Gene
Transcripts for MIRLET7A1 Gene
mRNA/cDNA for MIRLET7A1 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000362295 80 bps (ENST00000362295.3)
- (4) RNACentral transcripts :
- (12) ENA transcripts :
- (2) LncBase transcripts :
- (2) TarBase transcripts :
- (1) Rfam transcripts :
- (3) miRBase transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIRLET7A1 - Select products 50% OFF >
- * MIRLET7A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIRLET7A1 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIRLET7A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIRLET7A1 - Select products 50% OFF >
- * MIRLET7A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIRLET7A1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Addgene plasmids for MIRLET7A1
Expression for MIRLET7A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIRLET7A1 Gene:
MIRLET7A1Primer Products
-
OriGene qPCR primer pairs for MIRLET7A1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIRLET7A1 Gene
Orthologs for MIRLET7A1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7a-1 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-let-7a-1 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7a-1 33 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Mirlet7a-1 33 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | gga-let-7k 33 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | aca-let-7a 33 |
|
ManyToMany | |
| -- 33 |
|
ManyToMany | |||
| aca-let-7e 33 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | dre-let-7a-3 33 |
|
ManyToMany | |
| CR354430.2 33 |
|
ManyToMany | |||
| dre-let-7e 33 |
|
ManyToMany |
- Species where no ortholog for MIRLET7A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIRLET7A1 Gene
No data available for Paralogs for MIRLET7A1 Gene
Variants for MIRLET7A1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001069410 | -- | 94,174,436(+) | C/T | upstream_transcript_variant | |
| rs1001242486 | -- | 94,174,454(+) | G/A | upstream_transcript_variant | |
| rs1001589170 | -- | 94,174,757(+) | C/T | upstream_transcript_variant | |
| rs1002261112 | -- | 94,176,065(+) | G/T | downstream_transcript_variant | |
| rs1002305969 | -- | 94,175,091(+) | T/C | upstream_transcript_variant |
Additional Variant Information for MIRLET7A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIRLET7A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIRLET7A1 Gene
Disorders for MIRLET7A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| pituitary adenoma |
|
|
| hepatocellular carcinoma |
|
|
| reproductive system disease |
|
|
Search MIRLET7A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIRLET7A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIRLET7A1 Gene
Publications for MIRLET7A1 Gene
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 43 56
- H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7. (PMID: 29523225) Kou N … Liu H (Oncology research 2019) 3 56
- Tumor suppressor let-7a inhibits breast cancer cell proliferation, migration and invasion by targeting MAGE-A1. (PMID: 30509089) Mi Y … Geng C (Neoplasma 2019) 3 56
- ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer. (PMID: 30279206) Zhang Z … Duan W (Bioscience reports 2018) 3 56
- Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1. (PMID: 30066899) Zhao W … Xie SY (Oncology reports 2018) 3 56
Products for MIRLET7A1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
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- Origene Custom Protein Services for MIRLET7A1
- Browse OriGene Inhibitory RNA Products For MIRLET7A1
- OriGene qPCR primer pairs for MIRLET7A1
- Browse CRISPR knockouts for MIRLET7A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIRLET7A1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIRLET7A1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIRLET7A1
Sources for MIRLET7A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource