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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIRLET7A1 (MicroRNA Let-7a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIRLET7A1 include Colorectal Cancer and Pituitary Adenoma. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19878981 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 18766170 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Metastatic brain tumor | ||
3 | miRNAs involved in DNA damage response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 17671087 |
GO:0070104 | negative regulation of interleukin-6-mediated signaling pathway | IDA | 19878981 |
GO:0098806 | deadenylation involved in gene silencing by miRNA | IMP | 17671087 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000416056_9606 | miRNA | 22 | 6 |
RefSeq: NR_029476, NR_029477, NR_029478, LncBase: hsa-let-7a-5p, miRBase: MIMAT0000062, MirGeneDB: Hsa-Let-7-P1a_5p, Hsa-Let-7-P2a1_5p, Hsa-Let-7-P2a2_5p, TarBase: hsa-let-7a-5p, ENA: View 8 records in RNAcentral |
URS000004F5D8_9606 | miRNA | 21 | 6 |
LncBase: hsa-let-7a-3p, miRBase: MIMAT0004481, MirGeneDB: Hsa-Let-7-P2a1_3p, Hsa-Let-7-P2a2_3p, TarBase: hsa-let-7a-3p, ENA: LM380162.1:1..21:ncRNA, LM608149.1:57..77:ncRNA, LM608151.1:52..72:ncRNA, |
URS00005EB5B7_9606 | precursor_RNA | 80 | 5 |
HGNC: 31476, RefSeq: NR_029476, Ensembl: ENST00000362295 (view in UCSC) , miRBase: MI0000060, |
URS00001DF052_9606 | precursor_RNA | 82 | 1 |
Rfam: RF00027, |
URS0000EFE28C_9606 | precursor_RNA | 73 | 1 |
MirGeneDB: Hsa-Let-7-P2a1, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-let-7a-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-let-7a-1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-let-7a-1 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Mirlet7a-1 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | gga-let-7k 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | aca-let-7a 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
aca-let-7e 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | dre-let-7a-3 31 |
|
ManyToMany | |
CR354430.2 31 |
|
ManyToMany | |||
dre-let-7e 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer |
|
|
pituitary adenoma |
|
|
oral squamous cell carcinoma |
|
|
cholesteatoma of middle ear |
|
|
hepatocellular carcinoma |
|