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Aliases for MIR99B Gene

Subcategory (RNA class) for MIR99B Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR99B Gene

  • MicroRNA 99b 2 3 5
  • Hsa-Mir-99b 3
  • Mir-99b 3
  • MIRN99B 3

External Ids for MIR99B Gene

ORGUL Members for MIR99B Gene

Previous HGNC Symbols for MIR99B Gene

  • MIRN99B

Previous GeneCards Identifiers for MIR99B Gene

  • GC19P056922
  • GC19P056926
  • GC19P052195

Summaries for MIR99B Gene

Entrez Gene Summary for MIR99B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR99B Gene

MIR99B (MicroRNA 99b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR99B include Facioscapulohumeral Muscular Dystrophy 1 and Dermatomyositis.

Additional gene information for MIR99B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR99B Gene

Genomics for MIR99B Gene

GeneHancer (GH) Regulatory Elements for MIR99B Gene

Promoters and enhancers for MIR99B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -142.8 -142839 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B ZNF175 ZNF841 ZNF836 SIGLEC6 ZNF616 ZNF350 ZNF808 CTU1 ZNF613 ZNF766
GH19J051748 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 10.8 +57.9 57889 5 CEBPB FPR1 FPR2 SIGLEC10 FPR3 MIR99B MIRLET7E MIR125A SPACA6 ZNF350 HAS1
GH19J051438 Enhancer 0.6 ENCODE 9.9 -254.2 -254200 0.1 CTCF PKNOX1 TRIM22 SIN3A MIER2 REST RAD21 IKZF1 ZNF143 EHMT2 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 NKG7 CLDND2 ETFB MIR99B
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.7 -2.1 -2121 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR99B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR99B Gene

Genomic Locations for MIR99B Gene
chr19:51,692,612-51,692,681
(GRCh38/hg38)
Size:
70 bases
Orientation:
Plus strand
chr19:52,195,865-52,195,934
(GRCh37/hg19)
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR99B Gene

Genes around MIR99B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR99B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR99B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR99B Gene

Proteins for MIR99B Gene

Post-translational modifications for MIR99B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR99B Gene

Domains & Families for MIR99B Gene

Gene Families for MIR99B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR99B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR99B Gene

Function for MIR99B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR99B Gene

Localization for MIR99B Gene

Gene Ontology (GO) - Cellular Components for MIR99B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR99B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR99B Gene

Pathways & Interactions for MIR99B Gene

SuperPathways for MIR99B Gene

No Data Available

Interacting Proteins for MIR99B Gene

Gene Ontology (GO) - Biological Process for MIR99B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045429 positive regulation of nitric oxide biosynthetic process IDA 22232059
GO:0045603 positive regulation of endothelial cell differentiation IDA 22232059
GO:0045766 positive regulation of angiogenesis IDA 22232059
genes like me logo Genes that share ontologies with MIR99B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR99B Gene

Drugs & Compounds for MIR99B Gene

No Compound Related Data Available

Transcripts for MIR99B Gene

mRNA/cDNA for MIR99B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR99B Gene

No ASD Table

Relevant External Links for MIR99B Gene

GeneLoc Exon Structure for
MIR99B
ECgene alternative splicing isoforms for
MIR99B

Expression for MIR99B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR99B Gene:

MIR99B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR99B Gene

Orthologs for MIR99B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR99B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-99b 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-99b 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir99b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-99b 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-100 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10a 34
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-100 34
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-99b 34
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-10d 34
  • 28 (a)
ManyToMany
Species where no ortholog for MIR99B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR99B Gene

ENSEMBL:
Gene Tree for MIR99B (if available)
TreeFam:
Gene Tree for MIR99B (if available)

Paralogs for MIR99B Gene

No data available for Paralogs for MIR99B Gene

Variants for MIR99B Gene

Sequence variations from dbSNP and Humsavar for MIR99B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000093001 -- 51,690,920(+) /A upstream_transcript_variant
rs1000530929 -- 51,692,052(+) G/A upstream_transcript_variant
rs1000647040 -- 51,692,365(+) G/A upstream_transcript_variant
rs1003007762 -- 51,691,352(+) G/A upstream_transcript_variant
rs1003022639 -- 51,691,127(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR99B Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for MIR99B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR99B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR99B Gene

Disorders for MIR99B Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR99B Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR99B

genes like me logo Genes that share disorders with MIR99B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR99B Gene

Publications for MIR99B Gene

  1. ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. (PMID: 28408353) Ma J … Liu Z (Cancer letters 2017) 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients. (PMID: 27738339) Lukamowicz-Rajska M … Moch H (Oncotarget 2016) 3 58
  4. miR-99b suppresses IGF-1R expression and contributes to inhibition of cell proliferation in human epidermal keratinocytes. (PMID: 26297545) Li J … Wang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3 58
  5. miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. (PMID: 26259252) Li W … Li J (Oncotarget 2015) 3 58

Products for MIR99B Gene

Sources for MIR99B Gene

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