microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR99A Gene

Subcategory (RNA class) for MIR99A Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR99A Gene

  • MicroRNA 99a 2 3 5
  • Hsa-MiR-99a-3p 166 177
  • Hsa-MiR-99a-5p 166 177
  • MIMAT0000097 51
  • MIMAT0004511 51
  • Hsa-Mir-99a 3
  • MI0000101 51
  • Mir-99a 3
  • MIRN99A 3
  • RF00104 172
  • MIR99A 2

External Ids for MIR99A Gene

Previous HGNC Symbols for MIR99A Gene

  • MIRN99A

Previous GeneCards Identifiers for MIR99A Gene

  • GC21P016841
  • GC21P017911

Summaries for MIR99A Gene

Entrez Gene Summary for MIR99A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR99A Gene

MIR99A (MicroRNA 99a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR99A include Diabetes Mellitus and Down Syndrome. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR99A Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR99A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR99A Gene

Genomics for MIR99A Gene

GeneHancer (GH) Regulatory Elements for MIR99A Gene

Promoters and enhancers for MIR99A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J016586 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +48.7 48656 3 EP300 USF1 JUND FOS ZNF10 REST TCF7 ZBTB26 MXI1 ZNF341 MIR99A MIRLET7C MIR125B2 ENSG00000269950 MIR99AHG
GH21J016578 Enhancer 1.4 VISTA UCNEbase Ensembl ENCODE CraniofacialAtlas 11.5 +41.0 40951 2.7 MAFF MAFK POLR2A MIR99A MIRLET7C ENSG00000269950 lnc-BTG3-10 lnc-USP25-11 MIR99AHG
GH21J016570 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.6 +32.0 31982 3.1 CEBPB NFE2 MAFK FOS EP300 NFE2L2 ATF2 MAFF ZNF680 FOXA1 MIR99A MIRLET7C lnc-BTG3-10 lnc-USP25-11 MIR99AHG
GH21J016563 Enhancer 0.9 Ensembl ENCODE 11.7 +24.9 24880 1.7 TCF12 TEAD4 EP300 TEAD1 NR2F2 RXRA YY1 CEBPB CHD2 RCOR1 MIR99A MIRLET7C lnc-BTG3-10 lnc-USP25-11 MIR99AHG
GH21J016573 Enhancer 0.5 Ensembl ENCODE dbSUPER 11.6 +34.7 34735 1.6 MIR99A MIRLET7C lnc-BTG3-10 lnc-USP25-11 MIR99AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR99A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR99A Gene

Genomic Locations for MIR99A Gene
chr21:16,539,089-16,539,169
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr21:17,911,409-17,911,489
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR99A Gene

Genes around MIR99A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR99A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR99A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR99A Gene

Proteins for MIR99A Gene

Post-translational modifications for MIR99A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR99A Gene

Domains & Families for MIR99A Gene

Gene Families for MIR99A Gene

genes like me logo Genes that share domains with MIR99A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR99A Gene

Function for MIR99A Gene

Gene Ontology (GO) - Molecular Function for MIR99A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26455324
genes like me logo Genes that share ontologies with MIR99A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR99A Gene

Localization for MIR99A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR99A gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR99A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR99A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR99A Gene

Pathways & Interactions for MIR99A Gene

PathCards logo

SuperPathways for MIR99A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR99A: view

Pathways by source for MIR99A Gene

1 KEGG pathway for MIR99A Gene
;

Gene Ontology (GO) - Biological Process for MIR99A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 26455324
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA 26455324
GO:1904893 negative regulation of STAT cascade IDA 26455324
genes like me logo Genes that share ontologies with MIR99A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR99A Gene

Drugs & Compounds for MIR99A Gene

No Compound Related Data Available

Transcripts for MIR99A Gene

mRNA/cDNA for MIR99A Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
9 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR99A Gene

No ASD Table

Relevant External Links for MIR99A Gene

GeneLoc Exon Structure for
MIR99A

Expression for MIR99A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR99A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR99A

genes like me logo Genes that share expression patterns with MIR99A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR99A Gene

Orthologs for MIR99A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR99A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-99a 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-99a 31
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir99a 31
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-99a-1 31
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-99 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-99a 31
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-99a 31
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir99-2 31
  • 80 (a)
OneToMany
dre-mir-99-1 31
  • 79 (a)
OneToMany
Species where no ortholog for MIR99A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR99A Gene

ENSEMBL:
Gene Tree for MIR99A (if available)
TreeFam:
Gene Tree for MIR99A (if available)

Paralogs for MIR99A Gene

No data available for Paralogs for MIR99A Gene

Variants for MIR99A Gene

Additional dbSNP identifiers (rs#s) for MIR99A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR99A Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Additional Variant Information for MIR99A Gene

Human Gene Mutation Database (HGMD)
MIR99A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR99A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR99A Gene

Disorders for MIR99A Gene

MalaCards: The human disease database

(43) MalaCards diseases for MIR99A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus
  • diabetes
down syndrome
  • trisomy 21
endometriosis
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR99A

genes like me logo Genes that share disorders with MIR99A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR99A Gene

Publications for MIR99A Gene

  1. Silence of lncRNA ANRIL represses cell growth and promotes apoptosis in retinoblastoma cells through regulating miR-99a and c-Myc. (PMID: 31184221) Wang X … Hu J (Artificial cells, nanomedicine, and biotechnology 2019) 3 54
  2. MicroRNA-99a-5p alleviates atherosclerosis via regulating Homeobox A1. (PMID: 31325426) Han Z … Jing B (Life sciences 2019) 3 54
  3. MiRNA-99a can regulate proliferation and apoptosis of human granulosa cells via targeting IGF-1R in polycystic ovary syndrome. (PMID: 30374732) Geng Y … Jin L (Journal of assisted reproduction and genetics 2019) 3 54
  4. Expression level and prospective mechanism of miRNA-99a-3p in head and neck squamous cell carcinoma based on miRNA-chip and miRNA-sequencing data in 1, 167 cases. (PMID: 30904360) Wei GG … Zhang LC (Pathology, research and practice 2019) 3 54
  5. Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2. (PMID: 30816432) Osako Y … Enokida H (International journal of oncology 2019) 3 54

Products for MIR99A Gene

Sources for MIR99A Gene