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Aliases for MIR99A Gene

Subcategory (RNA class) for MIR99A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR99A Gene

  • MicroRNA 99a 2 3 5
  • Hsa-Mir-99a 3
  • Mir-99a 3
  • MIRN99A 3

External Ids for MIR99A Gene

Previous HGNC Symbols for MIR99A Gene

  • MIRN99A

Previous GeneCards Identifiers for MIR99A Gene

  • GC21P016841
  • GC21P017911

Summaries for MIR99A Gene

Entrez Gene Summary for MIR99A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR99A Gene

MIR99A (MicroRNA 99a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR99A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR99A Gene

Genomics for MIR99A Gene

GeneHancer (GH) Regulatory Elements for MIR99A Gene

Promoters and enhancers for MIR99A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I016586 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +48.7 48656 3 ELF3 FOXA2 SIN3A RAD21 RFX5 YY1 ZNF335 GLIS2 ZNF143 RCOR1 MIR99A MIRLET7C MIR125B2 ENSG00000269950 MIR99AHG
GH21I016578 Enhancer 1.4 VISTA UCNEbase Ensembl ENCODE 11.5 +40.9 40927 2.6 MAFF MAFK MIRLET7C MIR99A ENSG00000269950 GC21P016557 PIR42144 MIR99AHG
GH21I016563 Enhancer 0.9 Ensembl ENCODE 11.7 +24.9 24861 1.2 SOX13 MAX RAD21 ETS1 RFX5 TEAD3 GATA3 RCOR1 CHD2 TCF7L2 MIR99A MIRLET7C ENSG00000269950 PIR42144 GC21P016557 MIR99AHG
GH21I016570 Enhancer 0.7 ENCODE dbSUPER 11.6 +31.3 31338 0.4 MAFF CEBPB NFE2 EP300 NFE2L2 MIR99A MIRLET7C ENSG00000269950 GC21P016557 PIR42144 MIR99AHG
GH21I016573 Enhancer 0.6 Ensembl ENCODE dbSUPER 11.6 +34.8 34764 1.6 MIR99A MIRLET7C ENSG00000269950 GC21P016557 PIR42144 MIR99AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR99A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR99A Gene

Genomic Locations for MIR99A Gene
chr21:16,539,089-16,539,169
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr21:17,911,409-17,911,489
(GRCh37/hg19)

Genomic View for MIR99A Gene

Genes around MIR99A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR99A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR99A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR99A Gene

Proteins for MIR99A Gene

Post-translational modifications for MIR99A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR99A Gene

Domains & Families for MIR99A Gene

Gene Families for MIR99A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR99A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR99A Gene

Function for MIR99A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR99A Gene

Localization for MIR99A Gene

Gene Ontology (GO) - Cellular Components for MIR99A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR99A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR99A Gene

Pathways & Interactions for MIR99A Gene

SuperPathways for MIR99A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR99A: view

Pathways by source for MIR99A Gene

1 KEGG pathway for MIR99A Gene

Interacting Proteins for MIR99A Gene

Gene Ontology (GO) - Biological Process for MIR99A Gene

None

No data available for SIGNOR curated interactions for MIR99A Gene

Drugs & Compounds for MIR99A Gene

No Compound Related Data Available

Transcripts for MIR99A Gene

mRNA/cDNA for MIR99A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR99A Gene

No ASD Table

Relevant External Links for MIR99A Gene

GeneLoc Exon Structure for
MIR99A
ECgene alternative splicing isoforms for
MIR99A

Expression for MIR99A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR99A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR99A Gene:

MIR99A
genes like me logo Genes that share expression patterns with MIR99A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR99A Gene

Orthologs for MIR99A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR99A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-99a 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-99a 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir99a 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-99a-1 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-99 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-99a 34
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-99a 34
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir99-2 34
  • 80 (a)
OneToMany
dre-mir-99-1 34
  • 79 (a)
OneToMany
Species where no ortholog for MIR99A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR99A Gene

ENSEMBL:
Gene Tree for MIR99A (if available)
TreeFam:
Gene Tree for MIR99A (if available)

Paralogs for MIR99A Gene

No data available for Paralogs for MIR99A Gene

Variants for MIR99A Gene

Sequence variations from dbSNP and Humsavar for MIR99A Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1001234213 -- 16,538,598(+) G/A upstream_transcript_variant
rs1001266684 -- 16,538,886(+) A/T upstream_transcript_variant
rs1002217823 -- 16,537,279(+) G/T upstream_transcript_variant
rs1002553262 -- 16,538,512(+) T/A upstream_transcript_variant
rs1006184333 -- 16,537,626(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR99A Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073
esv3893374 CNV loss 25118596

Additional Variant Information for MIR99A Gene

Human Gene Mutation Database (HGMD)
MIR99A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR99A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR99A Gene

Disorders for MIR99A Gene

Additional Disease Information for MIR99A

No disorders were found for MIR99A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR99A Gene

Publications for MIR99A Gene

  1. The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy. (PMID: 27886437) Lin Y … Lu M (Cellular microbiology 2017) 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma. (PMID: 26455324) Lin KY … Chen YQ (Oncogene 2016) 3 58
  4. MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. (PMID: 27994509) Zhang Y … Xu S (International journal of biological sciences 2016) 3 58
  5. Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer. (PMID: 27706621) Li J … Nan X (Genetics and molecular research : GMR 2016) 3 58

Products for MIR99A Gene

Sources for MIR99A Gene

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