microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR98 Gene

RNA type for MIR98 Gene

miRNA

Aliases for MIR98 Gene

External Ids for MIR98 Gene

Previous HGNC Symbols for MIR98 Gene

  • MIRN98

Previous GeneCards Identifiers for MIR98 Gene

  • GC0XM053601
  • GC0XM053589
  • GC0XM053592
  • GC0XM053561
  • GC0XM053562
  • GC0XM053572
  • GC0XM053573
  • GC0XM053557
  • GC0XM053576
  • GC0XM053563
  • GC0XM053565
  • GC0XM053566
  • GC0XM053567
  • GC0XM053568
  • GC0XM053569
  • GC0XM053570
  • GC0XM053571
  • GC0XM053582
  • GC0XM053585

Summaries for MIR98 Gene

Entrez Gene Summary for MIR98 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR98 Gene

MIR98 (MicroRNA 98) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR98 include Niemann-Pick Disease, Type C1 and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Toll-like Receptor Signaling Pathway.

Rfam classification for MIR98 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR98 Gene

Genomics for MIR98 Gene

Genomic Locations for MIR98 Gene

Latest Assembly
chrX:53,556,223-53,556,341
(GRCh38/hg38)
Size:
119 bases
Orientation:
Minus strand

Previous Assembly
chrX:53,583,184-53,583,302
(GRCh37/hg19 by Entrez Gene)
Size:
119 bases
Orientation:
Minus strand

chrX:53,583,184-53,583,302
(GRCh37/hg19 by Ensembl)
Size:
119 bases
Orientation:
Minus strand

Genomic View for MIR98 Gene

Genes around MIR98 on UCSC Golden Path with GeneCards custom track
MIR98 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR98 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR98 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR98 Gene

Proteins for MIR98 Gene

Post-translational modifications for MIR98 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR98 Gene

Domains & Families for MIR98 Gene

Gene Families for MIR98 Gene

genes like me logo Genes that share domains with MIR98: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR98 Gene

Function for MIR98 Gene

Phenotypes From GWAS Catalog for MIR98 Gene

Gene Ontology (GO) - Molecular Function for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 31886314
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26098770
genes like me logo Genes that share ontologies with MIR98: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR98 Gene

Localization for MIR98 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR98 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR98: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR98 Gene

Pathways & Interactions for MIR98 Gene

PathCards logo

SuperPathways for MIR98 Gene

genes like me logo Genes that share pathways with MIR98: view

Pathways by source for MIR98 Gene

1 BioSystems pathway for MIR98 Gene

Gene Ontology (GO) - Biological Process for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 31886314
GO:0010629 negative regulation of gene expression IDA 31886314
GO:0010716 negative regulation of extracellular matrix disassembly IDA 26587789
GO:0032691 negative regulation of interleukin-1 beta production IGI 31886314
GO:0032693 negative regulation of interleukin-10 production IDA 29702181
genes like me logo Genes that share ontologies with MIR98: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR98 Gene

Drugs & Compounds for MIR98 Gene

No Compound Related Data Available

Transcripts for MIR98 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR98 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004E0808_9606 miRNA 22 6

RefSeq: NR_029513,

LncBase: hsa-miR-98-5p,

miRBase: MIMAT0000096,

MirGeneDB: Hsa-Let-7-P2b3_5p,

TarBase: hsa-miR-98-5p,

ENA: AF480536.1:1..22:ncRNA, LM378783.1:1..22:ncRNA, LM608186.1:22..43:ncRNA,

URS000075BF40_9606 pre_miRNA 119 4

RefSeq: NR_029513,

Ensembl: ENST00000606724 (view in UCSC) ,

miRBase: MI0000100,

ENA: LM608186.1:1..119:precursor_RNA,

URS0000122ED0_9606 miRNA 22 4

RefSeq: NR_029513,

LncBase: hsa-miR-98-3p,

miRBase: MIMAT0022842,

ENA: LM383042.1:1..22:ncRNA, LM608186.1:80..101:ncRNA,

URS0000688C7B_9606 pre_miRNA 89 1

Rfam: RF00027,

URS0000544B5A_9606 pre_miRNA 80 1

ENA: AF480570.1:1..80:misc_RNA,

MIR98 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR98 Gene

3 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR98 Gene

No ASD Table

Relevant External Links for MIR98 Gene

GeneLoc Exon Structure for
MIR98

Expression for MIR98 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR98 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR98

genes like me logo Genes that share expression patterns with MIR98: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR98 Gene

Orthologs for MIR98 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR98 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-98 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-98 30
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-98 30
  • 94 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir98 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 56 (a)
OneToMany
oan-mir-98 30
  • 55 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-let-7a-3 30
  • 74 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-98 30
  • 88 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-let-7h 30
  • 62 (a)
OneToOne
Species where no ortholog for MIR98 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR98 Gene

ENSEMBL:
Gene Tree for MIR98 (if available)
TreeFam:
Gene Tree for MIR98 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR98

Paralogs for MIR98 Gene

No data available for Paralogs for MIR98 Gene

Variants for MIR98 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR98 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR98 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv3576879 CNV gain 25503493
nsv435891 CNV deletion 17901297

Additional Variant Information for MIR98 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR98
Leiden Open Variation Database (LOVD)
MIR98

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR98 Gene

Disorders for MIR98 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR98 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
niemann-pick disease, type c1
  • npc1
squamous cell carcinoma, head and neck
  • hnscc
lung cancer
  • lung cancer, susceptibility to
hypersensitivity reaction type iii disease
  • immune complex disease
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search MIR98 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR98

genes like me logo Genes that share disorders with MIR98: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR98 Gene

Publications for MIR98 Gene

  1. miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. (PMID: 19671678) Du L … Pertsemlidis A (Molecular cancer research : MCR 2009) 3 72
  2. MiRNA-98 inhibits ovarian carcinoma cell proliferation, migration and invasion via targeting SALL4. (PMID: 31282134) Wang Z … Guan Y (Minerva medica 2021) 3
  3. miR-98-5p promotes apoptosis and inhibits migration and cell growth in papillary thyroid carcinoma through Bax/Caspase-3 by HMGA2. (PMID: 31670857) Qiu K … Lin T (Journal of clinical laboratory analysis 2020) 3
  4. ALG3 contributes to the malignancy of non-small cell lung cancer and is negatively regulated by MiR-98-5p. (PMID: 31899049) Ke SB … Chen YS (Pathology, research and practice 2020) 3
  5. MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF-κB-Inducing Kinase. (PMID: 32469170) Fei X … Liu Y (Yonsei medical journal 2020) 3

Products for MIR98 Gene

Sources for MIR98 Gene