microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR98 Gene

Subcategory (RNA class) for MIR98 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR98 Gene

  • MicroRNA 98 2 3 5
  • MicroRNA Let-7l 2 3
  • Hsa-MiR-98-5p 166 177
  • Hsa-MiR-98-3p 166
  • MIMAT0000096 51
  • MIMAT0022842 51
  • Hsa-Mir-98 3
  • MI0000100 51
  • MIRLET7L 3
  • RF00027 172
  • MiR-98 3
  • MIRN98 3
  • MIR98 2

External Ids for MIR98 Gene

Previous HGNC Symbols for MIR98 Gene

  • MIRN98

Previous GeneCards Identifiers for MIR98 Gene

  • GC0XM053601
  • GC0XM053589
  • GC0XM053592
  • GC0XM053561
  • GC0XM053562
  • GC0XM053572
  • GC0XM053573
  • GC0XM053557
  • GC0XM053563
  • GC0XM053565
  • GC0XM053566
  • GC0XM053567
  • GC0XM053568
  • GC0XM053569
  • GC0XM053570
  • GC0XM053571

Summaries for MIR98 Gene

Entrez Gene Summary for MIR98 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR98 Gene

MIR98 (MicroRNA 98) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR98 include Niemann-Pick Disease, Type C1 and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Toll-like Receptor Signaling Pathway.

Rfam classification for MIR98 Gene

Additional gene information for MIR98 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR98 Gene

Genomics for MIR98 Gene

GeneHancer (GH) Regulatory Elements for MIR98 Gene

Promoters and enhancers for MIR98 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ053635 Enhancer 0.3 Ensembl 13.4 -79.4 -79360 0.2 ZNF770 HUWE1 MIR98 MIRLET7F2 lnc-HSD17B10-7 piR-50443-404 RF00017-8453 RF00017-8452
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR98 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR98 Gene

Genomic Locations for MIR98 Gene
chrX:53,556,223-53,556,341
(GRCh38/hg38)
Size:
119 bases
Orientation:
Minus strand
chrX:53,583,184-53,583,302
(GRCh37/hg19)
Size:
119 bases
Orientation:
Minus strand

Genomic View for MIR98 Gene

Genes around MIR98 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR98 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR98 Gene

Proteins for MIR98 Gene

Post-translational modifications for MIR98 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR98 Gene

Domains & Families for MIR98 Gene

Gene Families for MIR98 Gene

genes like me logo Genes that share domains with MIR98: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR98 Gene

Function for MIR98 Gene

Phenotypes From GWAS Catalog for MIR98 Gene

Gene Ontology (GO) - Molecular Function for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26098770
genes like me logo Genes that share ontologies with MIR98: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR98 Gene

Localization for MIR98 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR98 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR98: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR98 Gene

Pathways & Interactions for MIR98 Gene

PathCards logo

SuperPathways for MIR98 Gene

genes like me logo Genes that share pathways with MIR98: view

Pathways by source for MIR98 Gene

1 BioSystems pathway for MIR98 Gene
;

Gene Ontology (GO) - Biological Process for MIR98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010716 negative regulation of extracellular matrix disassembly IDA 26587789
GO:0035195 gene silencing by miRNA IDA 26098770
GO:0035278 miRNA mediated inhibition of translation IDA 27541017
GO:0043525 positive regulation of neuron apoptotic process IMP 27541017
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA 26587789
genes like me logo Genes that share ontologies with MIR98: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR98 Gene

Drugs & Compounds for MIR98 Gene

No Compound Related Data Available

Transcripts for MIR98 Gene

mRNA/cDNA for MIR98 Gene

6 RNACentral transcripts :
1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR98 Gene

No ASD Table

Relevant External Links for MIR98 Gene

GeneLoc Exon Structure for
MIR98

Expression for MIR98 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR98 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR98

genes like me logo Genes that share expression patterns with MIR98: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR98 Gene

Orthologs for MIR98 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR98 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-98 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-98 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-98 31
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir98 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
OneToMany
oan-mir-98 31
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-let-7a-3 31
  • 74 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-98 31
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-let-7h 31
  • 62 (a)
OneToOne
Species where no ortholog for MIR98 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR98 Gene

ENSEMBL:
Gene Tree for MIR98 (if available)
TreeFam:
Gene Tree for MIR98 (if available)

Paralogs for MIR98 Gene

No data available for Paralogs for MIR98 Gene

Variants for MIR98 Gene

Additional dbSNP identifiers (rs#s) for MIR98 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR98 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
esv3576879 CNV gain 25503493
nsv435891 CNV deletion 17901297

Additional Variant Information for MIR98 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR98

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR98 Gene

Disorders for MIR98 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR98 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
niemann-pick disease, type c1
  • npc1
squamous cell carcinoma, head and neck
  • hnscc
lung cancer
  • adenocarcinoma of lung
breast cancer
  • breast cancer, familial
henoch-schoenlein purpura
  • allergic purpura
- elite association - COSMIC cancer census association via MalaCards
Search MIR98 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR98

genes like me logo Genes that share disorders with MIR98: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR98 Gene

Publications for MIR98 Gene

  1. MicroRNA‑98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k‑Ras/Raf/MEK/ERK signaling pathway. (PMID: 30664191) Guo L … Ma H (International journal of oncology 2019) 3 54
  2. MiR-98-5p may be a Biomarker for Screening Bronchial Asthma in Children by Targeting IL-13. (PMID: 30868866) Du J … Wu Y (Clinical laboratory 2019) 3 54
  3. MicroRNA-98 targets HMGA2 to inhibit the development of retinoblastoma through mediating Wnt/β-catenin pathway. (PMID: 31033463) Li W … Zhao L (Cancer biomarkers : section A of Disease markers 2019) 3 54
  4. MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH. (PMID: 30535507) Wang Q … Yu T (Oncology reports 2019) 3 54
  5. MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. (PMID: 30387848) Jiang F … Wang Q (International journal of oncology 2019) 3 54

Products for MIR98 Gene

Sources for MIR98 Gene