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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include Deafness, Autosomal Dominant 50 and Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH07J129775 | Enhancer | 0.5 | ENCODE | 600.7 | -1.1 | -1057 | 0.2 | ZBTB17 POLR2A KLF17 TAF1 ZBTB6 | MIR183 MIR96 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H | |
GH07J129777 | Enhancer | 0.3 | ENCODE | 600.7 | -1.4 | -1407 | 0.2 | POLR2A BCOR | MIR183 MIR96 ENSG00000273329 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H | |
GH07J129771 | Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas | 0.7 | +2.3 | 2288 | 4.2 | PRDM10 ZNF692 ZIC2 PATZ1 ZBTB20 ZNF10 ZBTB17 ZFHX2 POLR2A SPI1 | MIR182 UBE2H ENSG00000273329 KLHDC10 MIR96 piR-62011 RF00017-6611 RF00017-6613 NRF1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23823476 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 25871906 |
GO:0045542 | positive regulation of cholesterol biosynthetic process | IGI | 23823476 |
GO:0045723 | positive regulation of fatty acid biosynthetic process | IGI | 23823476 |
GO:0071397 | cellular response to cholesterol | IDA | 23823476 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00004E4AD0_9606 | precursor_RNA | 78 | 6 |
HGNC: 31648, RefSeq: NR_029512, Ensembl: ENST00000362288 (view in UCSC) , miRBase: MI0000098, Rfam: RF00669, ENA: AF480568.1:1..78:misc_RNA, LM608185.1:1..78:precursor_RNA, |
URS000016FF9C_9606 | miRNA | 23 | 6 |
RefSeq: NR_029512, LncBase: hsa-miR-96-5p, miRBase: MIMAT0000095, MirGeneDB: Hsa-Mir-96-P1_5p, TarBase: hsa-miR-96-5p, |
URS00005176F0_9606 | miRNA | 22 | 5 |
RefSeq: NR_029512, LncBase: hsa-miR-96-3p, miRBase: MIMAT0004510, TarBase: hsa-miR-96-3p, |
URS0000EFBBA3_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-96-P1, |
URS000024D008_9606 | miRNA | 22 | 1 |
ENA: AF480534.1:1..22:ncRNA, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-96 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-96 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-96 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-96 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir96 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-96 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-96 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
667262 | Uncertain Significance: not specified | 129,774,774(-) | G/A | ||
rs41274239 | Benign/Likely Benign: not specified; not provided | 129,774,734(-) | A/G | NON_CODING_TRANSCRIPT_VARIANT | |
rs587776522 | Pathogenic: Deafness, autosomal dominant 50 | 129,774,757(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT | |
rs587776523 | Pathogenic: Deafness, autosomal dominant 50 | 129,774,756(-) | G/T | NON_CODING_TRANSCRIPT_VARIANT | |
rs73159662 | Benign/Likely Benign: not specified; not provided | 129,774,728(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
deafness, autosomal dominant 50 |
|
|
ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus |
|
|
pancreatic cancer |
|
|
autosomal dominant non-syndromic sensorineural deafness type dfna |
|
|
breast cancer |
|