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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR96 Gene
Subcategory (RNA class) for MIR96 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR96 Gene
External Ids for MIR96 Gene
- HGNC: 31648
- Entrez Gene: 407053
- Ensembl: ENSG00000199158
- OMIM: 611606
- miRBase: hsa-mir-96
Previous HGNC Symbols for MIR96 Gene
- MIRN96
- DFNA50
Previous GeneCards Identifiers for MIR96 Gene
- GC07M129203
- GC07M129414
Summaries for MIR96 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR96 Gene
MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include Deafness, Autosomal Dominant 50 and Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR96 Gene
-
microRNA mir-96
Additional gene information for MIR96 Gene
- HGNC(31648)
- Entrez Gene(407053)
- Ensembl(ENSG00000199158)
- OMIM(611606)
- Open Targets Platform(ENSG00000199158)
- Monarch Initiative
- Search for MIR96 at DataMed
- Search for MIR96 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR96 Gene
Genomics for MIR96 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR96 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J129775 | Enhancer | 0.5 | ENCODE | 600.7 | -1.1 | -1057 | 0.2 | ZBTB17 POLR2A KLF17 TAF1 ZBTB6 | MIR183 MIR96 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H | |
| GH07J129777 | Enhancer | 0.3 | ENCODE | 600.7 | -1.4 | -1407 | 0.2 | POLR2A BCOR | MIR183 MIR96 ENSG00000273329 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H | |
| GH07J129771 | Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas | 0.7 | +2.3 | 2288 | 4.2 | PRDM10 ZNF692 ZIC2 PATZ1 ZBTB20 ZNF10 ZBTB17 ZFHX2 POLR2A SPI1 | MIR182 UBE2H ENSG00000273329 KLHDC10 MIR96 piR-62011 RF00017-6611 RF00017-6613 NRF1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR96 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR96 Gene
Genomic Locations for MIR96 Gene
- chr7:129,774,692-129,774,769
- (GRCh38/hg38)
- Size:
- 78 bases
- Orientation:
- Minus strand
- chr7:129,414,532-129,414,609
- (GRCh37/hg19)
- Size:
- 78 bases
- Orientation:
- Minus strand
Genomic View for MIR96 Gene
Genes around MIR96 on UCSC Golden Path with GeneCards custom track
MIR96 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 7q32.2 by HGNC
- 7q32.2 by Entrez Gene
- 7q32.2 by Ensembl
MIR96 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR96 Gene
Proteins for MIR96 Gene
Post-translational modifications for MIR96 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR96
- Origene Custom Protein Services for MIR96
No data available for DME Specific Peptides for MIR96 Gene
Domains & Families for MIR96 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR96 Gene
Function for MIR96 Gene
Phenotypes From GWAS Catalog for MIR96 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23823476 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR96 - Select products 50% OFF >
- * MIR96 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR96
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR96 - Select products 50% OFF >
- * MIR96 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR96 Gene
Localization for MIR96 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR96 Gene
Pathways & Interactions for MIR96 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR96 Gene
1 KEGG pathway for MIR96 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 25871906 |
| GO:0045542 | positive regulation of cholesterol biosynthetic process | IGI | 23823476 |
| GO:0045723 | positive regulation of fatty acid biosynthetic process | IGI | 23823476 |
| GO:0071397 | cellular response to cholesterol | IDA | 23823476 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR96 Gene
Transcripts for MIR96 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR96 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00004E4AD0_9606 | precursor_RNA | 78 | 6 |
HGNC: 31648, RefSeq: NR_029512, Ensembl: ENST00000362288 (view in UCSC) , miRBase: MI0000098, Rfam: RF00669, ENA: AF480568.1:1..78:misc_RNA, LM608185.1:1..78:precursor_RNA, |
| URS000016FF9C_9606 | miRNA | 23 | 6 |
RefSeq: NR_029512, LncBase: hsa-miR-96-5p, miRBase: MIMAT0000095, MirGeneDB: Hsa-Mir-96-P1_5p, TarBase: hsa-miR-96-5p, |
| URS00005176F0_9606 | miRNA | 22 | 5 |
RefSeq: NR_029512, LncBase: hsa-miR-96-3p, miRBase: MIMAT0004510, TarBase: hsa-miR-96-3p, |
| URS0000EFBBA3_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-96-P1, |
| URS000024D008_9606 | miRNA | 22 | 1 |
ENA: AF480534.1:1..22:ncRNA, |
MIR96 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR96 Gene
- 3 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR96 - Select products 50% OFF >
- * MIR96 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR96
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR96 - Select products 50% OFF >
- * MIR96 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR96 Gene
- GeneLoc Exon Structure for
- MIR96
Expression for MIR96 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR96
Evidence on tissue expression from TISSUES for MIR96 Gene
- Blood(2.1)
- Nervous system(2.1)
- Liver(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR96 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- head
- inner ear
- middle ear
- outer ear
Thorax:
- heart
- heart valve
Limb:
- forearm
General:
- peripheral nerve
- peripheral nervous system
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIR96
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR96 Gene
Orthologs for MIR96 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-96 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-96 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-96 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-96 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir96 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-96 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-96 31 |
|
OneToOne |
- Species where no ortholog for MIR96 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR96 Gene
No data available for Paralogs for MIR96 Gene
Variants for MIR96 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR96 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 667262 | Uncertain Significance: not specified | 129,774,774(-) | G/A | ||
| rs41274239 | Benign/Likely Benign: not specified; not provided | 129,774,734(-) | A/G | NON_CODING_TRANSCRIPT_VARIANT | |
| rs587776522 | Pathogenic: Deafness, autosomal dominant 50 | 129,774,757(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT | |
| rs587776523 | Pathogenic: Deafness, autosomal dominant 50 | 129,774,756(-) | G/T | NON_CODING_TRANSCRIPT_VARIANT | |
| rs73159662 | Benign/Likely Benign: not specified; not provided | 129,774,728(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT |
Additional Variant Information for MIR96 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR96 Gene
Disorders for MIR96 Gene
(34) MalaCards diseases for MIR96 Gene - From: miR2Disease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal dominant 50 |
|
|
| ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus |
|
|
| pancreatic cancer |
|
|
| autosomal dominant non-syndromic sensorineural deafness type dfna |
|
|
| breast cancer |
|
Search MIR96 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR96
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR96 Gene
Publications for MIR96 Gene
- Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. (PMID: 19363479) Mencía A … Moreno-Pelayo MA (Nature genetics 2009) 2 3
- A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci. (PMID: 14757864) Modamio-Høybjør S … Moreno F (Journal of medical genetics 2004) 2 3
- MiRNA-96-5p contributed to the proliferation of gastric cancer cells by targeting FOXO3. (PMID: 31598681) He X … Zou K (Journal of biochemistry 2020) 3
- Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96. (PMID: 31325400) Zhang Y … Zhang X (Cancer science 2019) 3
- Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway. (PMID: 31545491) Zhang S … Guo W (Molecular medicine reports 2019) 3
ExternalLinks
Products for MIR96 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR96
- Origene Custom Protein Services for MIR96
- Browse OriGene Inhibitory RNA Products For MIR96
- OriGene qPCR primer pairs for MIR96
- Browse CRISPR knockouts for MIR96
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR96
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR96
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR96
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR96
Sources for MIR96 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB