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MIR96 Gene(RNA Gene)

MicroRNA 96

GCID:
GC07M129774
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR96 Gene

Subcategory (RNA class) for MIR96 Gene

miRNA

Quality Score for this RNA gene is

23

Aliases for MIR96 Gene

  • MicroRNA 96 2 3 5
  • Deafness, Autosomal Dominant 50 2
  • Hsa-Mir-96 3
  • MiRNA96 3
  • MiR-96 3
  • DFNA50 3
  • MIRN96 3

External Ids for MIR96 Gene

ORGUL Members for MIR96 Gene

Previous HGNC Symbols for MIR96 Gene

  • MIRN96
  • DFNA50

Previous GeneCards Identifiers for MIR96 Gene

  • GC07M129203
  • GC07M129414

Summaries for MIR96 Gene

Entrez Gene Summary for MIR96 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR96 Gene

MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include Deafness, Autosomal Dominant 50 and Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR96 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR96 Gene

Genomics for MIR96 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR96 Gene

Promoters and enhancers for MIR96 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J129775 Enhancer 0.5 ENCODE 650.7 -1.1 -1057 0.2 ZBTB6 KLF17 CTBP2 ZBTB17 GC07P129777 GC07M129786 MIR183 MIR96 GC07M129785
GH07J129777 Enhancer 0.4 ENCODE 650.7 -1.4 -1407 0.2 BCOR CTBP2 GC07P129777 GC07M129786 MIR183 MIR96 ENSG00000273329 GC07M129785
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR96 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR96 Gene

Genomic Locations for MIR96 Gene
chr7:129,774,692-129,774,769
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr7:129,414,532-129,414,609
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR96 Gene

Genes around MIR96 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR96 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR96 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR96 Gene

ORGUL Member Location for MIR96 Gene

ORGUL Member Location for MIR96 gene

Proteins for MIR96 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR96 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR96 Gene

Domains & Families for MIR96 Gene

Gene Families for MIR96 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR96: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR96 Gene

Function for MIR96 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Human Phenotype Ontology for MIR96 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR96 Gene

Localization for MIR96 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR96 Gene

Pathways & Interactions for MIR96 Gene

SuperPathways for MIR96 Gene

PathCards logo More details on SuperPathways for MIR96
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR96: view

Pathways by source for MIR96 Gene

1 KEGG pathway for MIR96 Gene

Interacting Proteins for MIR96 Gene

Gene Ontology (GO) - Biological Process for MIR96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 25871906
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP 25871906
genes like me logo Genes that share ontologies with MIR96: view

No data available for SIGNOR curated interactions for MIR96 Gene

Drugs & Compounds for MIR96 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR96 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR96 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR96 Gene

No ASD Table

Relevant External Links for MIR96 Gene

GeneLoc Exon Structure for
MIR96
ECgene alternative splicing isoforms for
MIR96

Expression for MIR96 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR96 Gene:

MIR96

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR96 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MIR96 Gene

Orthologs for MIR96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR96 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-96 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-96 34
  • 88 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-96 34
  • 75 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-96 34
  • 75 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir96 34
  • 72 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-96 34
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 34
  • 63 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-96 34
  • 50 (a)
 OneToOne
Species where no ortholog for MIR96 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR96 Gene

ENSEMBL:
Gene Tree for MIR96 (if available)
TreeFam:
Gene Tree for MIR96 (if available)

Paralogs for MIR96 Gene

No data available for Paralogs for MIR96 Gene

Variants for MIR96 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR96 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs587776522 pathogenic, Deafness, autosomal dominant 50 129,774,757(-) C/T non_coding_transcript_variant
rs587776523 pathogenic, Deafness, autosomal dominant 50 129,774,756(-) G/T non_coding_transcript_variant
rs72631833 likely-benign, not specified 129,774,964(-) C/A upstream_transcript_variant
rs73159662 likely-benign, not specified 129,774,728(-) G/A non_coding_transcript_variant
rs41274239 benign, not specified 129,774,734(-) A/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR96 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Additional Variant Information for MIR96 Gene

Human Gene Mutation Database (HGMD)
MIR96
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR96

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR96 Gene

Disorders for MIR96 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR96 Gene - From: miR2Disease, HGMD, OMIM, ClinVar, GTR, Orphanet, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MIR96 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR96

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR96: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR96 Gene

Publications for MIR96 Gene

  1. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. (PMID: 19363479) Mencía A … Moreno-Pelayo MA (Nature genetics 2009) 2 3 58
  2. A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci. (PMID: 14757864) Modamio-Høybjør S … Moreno F (Journal of medical genetics 2004) 2 3 58
  3. MicroRNA-96 Promotes Tumor Invasion in Colorectal Cancer via RECK. (PMID: 29599320) Iseki Y … Ohira M (Anticancer research 2018) 3 58
  4. MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells. (PMID: 26846266) Ma QQ … Zhu WW (Technology in cancer research & treatment 2017) 3 58
  5. Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. (PMID: 27746161) Tsai YC … Liu YN (Cancer letters 2017) 3 58

Products for MIR96 Gene

Sources for MIR96 Gene

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