microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR96 Gene

Subcategory (RNA class) for MIR96 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR96 Gene

  • MicroRNA 96 2 3 5
  • Hsa-MiR-96-5p 163 173
  • Hsa-MiR-96-3p 163 173
  • Hsa-Mir-96 2 3
  • MIR96 2 5
  • Deafness, Autosomal Dominant 50 2
  • Hsa-Mir-96-P1 178
  • MIMAT0000095 50
  • MIMAT0004510 50
  • MI0000098 50
  • MiRNA96 3
  • RF00669 168
  • DFNA50 3
  • MIRN96 3
  • MiR-96 3

External Ids for MIR96 Gene

Previous HGNC Symbols for MIR96 Gene

  • MIRN96
  • DFNA50

Previous GeneCards Identifiers for MIR96 Gene

  • GC07M129203
  • GC07M129414

Summaries for MIR96 Gene

Entrez Gene Summary for MIR96 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR96 Gene

MIR96 (MicroRNA 96) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR96 include Deafness, Autosomal Dominant 50 and Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR96 Gene

Additional gene information for MIR96 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR96 Gene

Genomics for MIR96 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR96 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J129775 Enhancer 0.5 ENCODE 600.7 -1.1 -1057 0.2 ZBTB17 POLR2A KLF17 TAF1 ZBTB6 MIR183 MIR96 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
GH07J129777 Enhancer 0.3 ENCODE 600.7 -1.4 -1407 0.2 POLR2A BCOR MIR183 MIR96 ENSG00000273329 ENSG00000242078 RF00017-6611 RF00017-6613 NRF1 UBE2H
GH07J129771 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 0.7 +2.3 2288 4.2 PRDM10 ZNF692 ZIC2 PATZ1 ZBTB20 ZNF10 ZBTB17 ZFHX2 POLR2A SPI1 MIR182 UBE2H ENSG00000273329 KLHDC10 MIR96 piR-62011 RF00017-6611 RF00017-6613 NRF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR96 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR96 Gene

Genomic Locations for MIR96 Gene
chr7:129,774,692-129,774,769
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr7:129,414,532-129,414,609
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR96 Gene

Genes around MIR96 on UCSC Golden Path with GeneCards custom track
MIR96 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR96 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR96 Gene

Proteins for MIR96 Gene

No data available for DME Specific Peptides for MIR96 Gene

Domains & Families for MIR96 Gene

Gene Families for MIR96 Gene

HGNC:
genes like me logo Genes that share domains with MIR96: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR96 Gene

Function for MIR96 Gene

Phenotypes From GWAS Catalog for MIR96 Gene

Gene Ontology (GO) - Molecular Function for MIR96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23823476
genes like me logo Genes that share ontologies with MIR96: view

Human Phenotype Ontology for MIR96 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR96 Gene

Localization for MIR96 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR96 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR96 Gene

Pathways & Interactions for MIR96 Gene

PathCards logo

SuperPathways for MIR96 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR96: view

Pathways by source for MIR96 Gene

1 KEGG pathway for MIR96 Gene

Gene Ontology (GO) - Biological Process for MIR96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 25871906
GO:0045542 positive regulation of cholesterol biosynthetic process IGI 23823476
GO:0045723 positive regulation of fatty acid biosynthetic process IGI 23823476
GO:0071397 cellular response to cholesterol IDA 23823476
genes like me logo Genes that share ontologies with MIR96: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR96 Gene

Drugs & Compounds for MIR96 Gene

No Compound Related Data Available

Transcripts for MIR96 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR96 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004E4AD0_9606 precursor_RNA 78 6

HGNC: 31648,

RefSeq: NR_029512,

Ensembl: ENST00000362288 (view in UCSC) ,

miRBase: MI0000098,

Rfam: RF00669,

ENA: AF480568.1:1..78:misc_RNA, LM608185.1:1..78:precursor_RNA,

URS000016FF9C_9606 miRNA 23 6

RefSeq: NR_029512,

LncBase: hsa-miR-96-5p,

miRBase: MIMAT0000095,

MirGeneDB: Hsa-Mir-96-P1_5p,

TarBase: hsa-miR-96-5p,

ENA: LM378782.1:1..23:ncRNA, LM608185.1:9..31:ncRNA,

URS00005176F0_9606 miRNA 22 5

RefSeq: NR_029512,

LncBase: hsa-miR-96-3p,

miRBase: MIMAT0004510,

TarBase: hsa-miR-96-3p,

ENA: LM380189.1:1..22:ncRNA, LM608185.1:52..73:ncRNA,

URS0000EFBBA3_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-96-P1,

URS000024D008_9606 miRNA 22 1

ENA: AF480534.1:1..22:ncRNA,

MIR96 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR96 Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR96 Gene

No ASD Table

Relevant External Links for MIR96 Gene

GeneLoc Exon Structure for
MIR96

Expression for MIR96 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR96

Evidence on tissue expression from TISSUES for MIR96 Gene

  • Blood(2.1)
  • Nervous system(2.1)
  • Liver(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR96 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR96 Gene

Orthologs for MIR96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR96 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-96 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-96 31
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-96 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-96 31
  • 75 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir96 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-96 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-96 31
  • 50 (a)
OneToOne
Species where no ortholog for MIR96 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR96 Gene

ENSEMBL:
Gene Tree for MIR96 (if available)
TreeFam:
Gene Tree for MIR96 (if available)

Paralogs for MIR96 Gene

No data available for Paralogs for MIR96 Gene

Variants for MIR96 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR96 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
667262 Uncertain Significance: not specified 129,774,774(-) G/A
rs41274239 Benign/Likely Benign: not specified; not provided 129,774,734(-) A/G NON_CODING_TRANSCRIPT_VARIANT
rs587776522 Pathogenic: Deafness, autosomal dominant 50 129,774,757(-) C/T NON_CODING_TRANSCRIPT_VARIANT
rs587776523 Pathogenic: Deafness, autosomal dominant 50 129,774,756(-) G/T NON_CODING_TRANSCRIPT_VARIANT
rs73159662 Benign/Likely Benign: not specified; not provided 129,774,728(-) G/A NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIR96 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR96 Gene

Variant ID Type Subtype PubMed ID
esv23078 CNV gain 19812545
nsv464721 CNV loss 19166990
nsv516024 CNV gain+loss 19592680
nsv608420 CNV loss 21841781
nsv949946 CNV deletion 24416366

Additional Variant Information for MIR96 Gene

Human Gene Mutation Database (HGMD)
MIR96
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR96

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR96 Gene

Disorders for MIR96 Gene

MalaCards: The human disease database

(34) MalaCards diseases for MIR96 Gene - From: miR2Disease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MIR96 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MIR96: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR96 Gene

Publications for MIR96 Gene

  1. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. (PMID: 19363479) Mencía A … Moreno-Pelayo MA (Nature genetics 2009) 2 3
  2. A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci. (PMID: 14757864) Modamio-Høybjør S … Moreno F (Journal of medical genetics 2004) 2 3
  3. MiRNA-96-5p contributed to the proliferation of gastric cancer cells by targeting FOXO3. (PMID: 31598681) He X … Zou K (Journal of biochemistry 2020) 3
  4. Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96. (PMID: 31325400) Zhang Y … Zhang X (Cancer science 2019) 3
  5. Long non‑coding RNA MEG3 suppresses the growth of glioma cells by regulating the miR‑96‑5p/MTSS1 signaling pathway. (PMID: 31545491) Zhang S … Guo W (Molecular medicine reports 2019) 3

Products for MIR96 Gene

Sources for MIR96 Gene