microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR940 Gene

Subcategory (RNA class) for MIR940 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR940 Gene

  • MicroRNA 940 2 3 5
  • Hsa-MiR-940 168 179
  • MIMAT0004983 53
  • Hsa-Mir-940 3
  • MI0005762 53
  • Mir-940 3
  • MIRN940 3
  • RF01023 174
  • MIR940 2

External Ids for MIR940 Gene

Previous HGNC Symbols for MIR940 Gene

  • MIRN940

Previous GeneCards Identifiers for MIR940 Gene

  • GC16P002263
  • GC16P002321

Summaries for MIR940 Gene

Entrez Gene Summary for MIR940 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR940 Gene

MIR940 (MicroRNA 940) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR940 Gene

Additional gene information for MIR940 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR940 Gene

Genomics for MIR940 Gene

GeneHancer (GH) Regulatory Elements for MIR940 Gene

Promoters and enhancers for MIR940 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002439 Enhancer 0.6 Ensembl ENCODE 10.9 +168.5 168454 1.6 POLR2A ELF1 ZNF217 NTN3 TBC1D24 ABCA3 ABCA17P RNPS1 ECI1 MIR940 PKD1 ENSG00000215154 ENSG00000285970
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR940 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR940 Gene

Genomic Locations for MIR940 Gene
chr16:2,271,747-2,271,840
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr16:2,318,156-2,323,419
(GRCh37/hg19)
Size:
5,264 bases
Orientation:
Plus strand

Genomic View for MIR940 Gene

Genes around MIR940 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR940 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR940 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR940 Gene

Proteins for MIR940 Gene

Post-translational modifications for MIR940 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR940 Gene

Domains & Families for MIR940 Gene

Gene Families for MIR940 Gene

HGNC:
genes like me logo Genes that share domains with MIR940: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR940 Gene

Function for MIR940 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR940 Gene

Localization for MIR940 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR940 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR940 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR940: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR940 Gene

Pathways & Interactions for MIR940 Gene

PathCards logo

SuperPathways for MIR940 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR940 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR940: view

No data available for Pathways by source and SIGNOR curated interactions for MIR940 Gene

Drugs & Compounds for MIR940 Gene

No Compound Related Data Available

Transcripts for MIR940 Gene

mRNA/cDNA for MIR940 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(3) ENA transcripts :
(2) miRBase transcripts :
(1) LncBase transcripts :
(1) Rfam transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR940 Gene

No ASD Table

Relevant External Links for MIR940 Gene

GeneLoc Exon Structure for
MIR940
ECgene alternative splicing isoforms for
MIR940

Expression for MIR940 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR940 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR940 Gene:

MIR940
genes like me logo Genes that share expression patterns with MIR940: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR940 Gene

Orthologs for MIR940 Gene

Evolution for MIR940 Gene

ENSEMBL:
Gene Tree for MIR940 (if available)
TreeFam:
Gene Tree for MIR940 (if available)

No data available for Orthologs for MIR940 Gene

Paralogs for MIR940 Gene

No data available for Paralogs for MIR940 Gene

Variants for MIR940 Gene

Sequence variations from dbSNP and Humsavar for MIR940 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000205570 -- 2,270,509(+) T/C upstream_transcript_variant
rs1000593807 -- 2,271,557(+) C/T upstream_transcript_variant
rs1000657372 -- 2,270,200(+) A/G upstream_transcript_variant
rs1001401232 -- 2,271,497(+) A/C upstream_transcript_variant
rs1001601714 -- 2,271,017(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR940 Gene

Variant ID Type Subtype PubMed ID
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv457351 CNV loss 19166990
nsv457353 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571201 CNV loss 21841781
nsv952902 CNV deletion 24416366

Additional Variant Information for MIR940 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR940

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR940 Gene

Disorders for MIR940 Gene

Additional Disease Information for MIR940

No disorders were found for MIR940 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR940 Gene

Publications for MIR940 Gene

  1. MicroRNA‑940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel‑like factor 9. (PMID: 30431124) Zhang D … Wu S (Molecular medicine reports 2019) 3 56
  2. Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection. (PMID: 30475754) Zhuo X … Zhou Q (Cancer biomarkers : section A of Disease markers 2018) 3 56
  3. MicroRNA-940 Targets INPP4A or GSK3β and Activates the Wnt/β-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells. (PMID: 28337959) Wang R … Chen W (Oncology research 2018) 3 56
  4. Clinical potential of miR-940 as a diagnostic and prognostic biomarker in breast cancer patients. (PMID: 29843213) Liu W … Meng H (Cancer biomarkers : section A of Disease markers 2018) 3 56
  5. Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs. (PMID: 28423620) Rashed MH … Berestein GL (Oncotarget 2017) 3 56

Products for MIR940 Gene

Sources for MIR940 Gene