microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR939 Gene

Data sources for MIR939 Gene:

RNA type for MIR939 Gene

miRNA

Aliases for MIR939 Gene

External Ids for MIR939 Gene

Previous HGNC Symbols for MIR939 Gene

  • MIRN939

Previous GeneCards Identifiers for MIR939 Gene

  • GC08M145592
  • GC08M145621
  • GC08M145626
  • GC08M145627
  • GC08M140732
  • GC08M145630
  • GC08M145631
  • GC08M145632
  • GC08M145633

Summaries for MIR939 Gene

Entrez Gene Summary for MIR939 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR939 Gene

MIR939 (MicroRNA 939) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR939 include Myopia 27 and Myopia. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Tat-mediated elongation of the HIV-1 transcript.

Rfam classification for MIR939 Gene

Additional gene information for MIR939 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR939 Gene

Genomics for MIR939 Gene

Genomic Locations for MIR939 Gene

Latest Assembly
chr8:144,394,149-144,394,230
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand

Previous Assembly
chr8:145,619,364-145,619,445
(GRCh37/hg19 by Entrez Gene)
Size:
82 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr8(PATCHES):124,752-124,833 (-)

Genomic View for MIR939 Gene

Genes around MIR939 on UCSC Golden Path with GeneCards custom track
MIR939 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR939 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR939 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR939 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR939 Gene

Proteins for MIR939 Gene

Post-translational modifications for MIR939 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR939 Gene

Domains & Families for MIR939 Gene

Gene Families for MIR939 Gene

HGNC:
genes like me logo Genes that share domains with MIR939: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR939 Gene

Function for MIR939 Gene

Gene Ontology (GO) - Molecular Function for MIR939 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28115160
genes like me logo Genes that share ontologies with MIR939: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR939 Gene

Localization for MIR939 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR939 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR939 Gene

Pathways & Interactions for MIR939 Gene

genes like me logo Genes that share pathways with MIR939: view

Pathways by source for MIR939 Gene

Gene Ontology (GO) - Biological Process for MIR939 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 28115160
GO:0016525 negative regulation of angiogenesis IDA 28115160
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 28115160
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 28115160
genes like me logo Genes that share ontologies with MIR939: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR939 Gene

Drugs & Compounds for MIR939 Gene

No Compound Related Data Available

Transcripts for MIR939 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR939 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000069D7BD_9606 pre_miRNA 82 5

RefSeq: NR_030635,

Ensembl: ENST00000401314 (view in UCSC) ,

miRBase: MI0005761,

Rfam: RF00981,

ENA: LM609993.1:1..82:precursor_RNA,

URS00005A31EB_9606 miRNA 24 5

RefSeq: NR_030635,

LncBase: hsa-miR-939-5p,

miRBase: MIMAT0004982,

TarBase: hsa-miR-939-5p,

ENA: LM609993.1:15..38:ncRNA,

URS00003AD2AA_9606 miRNA 21 3

RefSeq: NR_030635,

miRBase: MIMAT0022939,

ENA: LM383091.1:1..21:ncRNA, LM609993.1:50..70:ncRNA,

URS0001BC8A6C_9606 pre_miRNA 82 1

Rfam: RF00981,

MIR939 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR939 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR939 Gene

No ASD Table

Relevant External Links for MIR939 Gene

GeneLoc Exon Structure for
MIR939

Expression for MIR939 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR939 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR939

genes like me logo Genes that share expression patterns with MIR939: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR939 Gene

Orthologs for MIR939 Gene

Evolution for MIR939 Gene

ENSEMBL:
Gene Tree for MIR939 (if available)
TreeFam:
Gene Tree for MIR939 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR939

No data available for Orthologs for MIR939 Gene

Paralogs for MIR939 Gene

No data available for Paralogs for MIR939 Gene

Variants for MIR939 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR939 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1554862601 Pathogenic: Myopia 27 144,394,149(-) C/A
NM_013291.3(CPSF1):c.3823G>T (p.Asp1275Tyr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR939 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR939 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2759652 CNV gain+loss 17122850
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612934 CNV loss 21841781
nsv824805 CNV gain 20364138
nsv831489 CNV loss 17160897

Additional Variant Information for MIR939 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR939
Leiden Open Variation Database (LOVD)
MIR939

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR939 Gene

Disorders for MIR939 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR939 Gene - From: CVR and GCD

Disorder Aliases PubMed IDs
myopia 27
  • myp27
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR939

genes like me logo Genes that share disorders with MIR939: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR939 Gene

Publications for MIR939 Gene

  1. CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection. (PMID: 30689892) Ouyang J … Zhang Q (Human molecular genetics 2019) 72
  2. lncRNA RP5-916L7.2 correlates with advanced tumor stage, and promotes cells proliferation while inhibits cells apoptosis through targeting miR-328 and miR-939 in tongue squamous cell carcinoma. (PMID: 30825424) Chen Y … Yan W (Clinical biochemistry 2019) 3
  3. MicroRNA-939-5p directly targets IGF-1R to inhibit the aggressive phenotypes of osteosarcoma through deactivating the PI3K/Akt pathway. (PMID: 31545400) Zhao X … Yu D (International journal of molecular medicine 2019) 3
  4. Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939‒Mediated Transcriptional Repression of Bcl-xL. (PMID: 29081216) Cui C … Yu J (Cancer research and treatment : official journal of Korean Cancer Association 2018) 3
  5. Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway. (PMID: 29721064) Li H … Ge J (Theranostics 2018) 3

Products for MIR939 Gene

Sources for MIR939 Gene