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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR938 (MicroRNA 938) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR938 include Type 1 Diabetes Mellitus 10.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J029603 | Enhancer | 0.6 | Ensembl ENCODE dbSUPER | 750.6 | -1.4 | -1354 | 3.4 | ZNF121 | MIR938 RNU6-908P SVIL-AS1 piR-31534-061 SVIL lnc-JCAD-7 | |
GH10J029605 | Enhancer | 0.4 | Ensembl dbSUPER | 750.6 | +0.9 | 946 | 0.4 | SCRT2 | MIR938 MIR604 RNU6-908P SVIL SVIL-AS1 ENSG00000212411 lnc-JCAD-7 | |
GH10J029582 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | +16.1 | 16054 | 10.2 | CTCF SREBF1 TCF7L2 RAD21 MNT ZNF280D ZNF384 NCOA3 ZSCAN21 ZNF687 | SVIL MIR604 CKS1BP2 RNU6-908P SVIL-AS1 ENSG00000212411 MIR938 lnc-JCAD-7 | |
GH10J029597 | Enhancer | 0.5 | ENCODE dbSUPER | 0.6 | +3.1 | 3084 | 3.3 | ZNF121 SCRT2 | MIR604 RNU6-908P SVIL SVIL-AS1 MIR938 ENSG00000212411 lnc-JCAD-7 | |
GH10J029611 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 0.4 | -10.2 | -10155 | 2.2 | NFIB PRDM10 CEBPB POLR2A NFIC KLF1 | piR-31534-061 SVIL MIR604 MIR938 lnc-JCAD-7 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016442 | RISC complex | IEA | -- |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-938 33 |
|
OneToOne |
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1002602309 | -- | 29,603,555(-) | T/C | upstream_transcript_variant | |
rs1002634713 | -- | 29,603,788(-) | T/C | upstream_transcript_variant | |
rs1003635410 | -- | 29,602,549(-) | T/C | upstream_transcript_variant | |
rs1003816153 | -- | 29,602,819(-) | C/A | upstream_transcript_variant | |
rs1004061619 | -- | 29,603,185(-) | C/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1129323 | OTHER | inversion | 24896259 |
nsv831819 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
type 1 diabetes mellitus 10 |
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