microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR937 Gene

Data sources for MIR937 Gene:

RNA type for MIR937 Gene

miRNA

Aliases for MIR937 Gene

External Ids for MIR937 Gene

Previous HGNC Symbols for MIR937 Gene

  • MIRN937

Previous GeneCards Identifiers for MIR937 Gene

  • GC08M144969
  • GC08M144895
  • GC08M140148
  • GC08M143798

Summaries for MIR937 Gene

Entrez Gene Summary for MIR937 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR937 Gene

MIR937 (MicroRNA 937) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR937 include Intracranial Berry Aneurysm. Among its related pathways are Signaling by GPCR and Human Thyroid Stimulating Hormone (TSH) signaling pathway.

Rfam classification for MIR937 Gene

Additional gene information for MIR937 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR937 Gene

Genomics for MIR937 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR937 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143813 Enhancer 0.8 ENCODE dbSUPER 250.7 -0.4 -364 0.2 ZNF217 CTBP1 SIN3A PKNOX1 DPF2 ZNF687 MNT CREB1 ESRRA RAD21 MIR937 SCRIB RF00017-6801 FAM83H
GH08J143812 Enhancer 0.3 dbSUPER 250.7 +0.3 270 0.8 DPF2 MIR937 PUF60 IQANK1 HSALNG0069337 SCRIB RF00017-6801 FAM83H
GH08J143814 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.3 -2330 2.7 BCLAF1 SP1 ZNF207 MYC SIX5 SSRP1 ZNF592 POLR2A ZIC2 NONO SCRIB AB372758 VPS28 CPSF1 LRRC14 ZNF623 ZNF251 ADCK5 ZNF34 PARP10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR937 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR937 Gene

Latest Assembly
chr8:143,812,957-143,813,042
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand

Previous Assembly
chr8:144,895,127-144,895,212
(GRCh37/hg19 by Entrez Gene)
Size:
86 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr8(ALT_REF_LOCI_1):290,004-290,089 (-)

Genomic View for MIR937 Gene

Genes around MIR937 on UCSC Golden Path with GeneCards custom track
MIR937 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR937 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR937 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR937 Gene

Proteins for MIR937 Gene

Post-translational modifications for MIR937 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR937 Gene

Domains & Families for MIR937 Gene

Gene Families for MIR937 Gene

HGNC:
genes like me logo Genes that share domains with MIR937: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR937 Gene

Function for MIR937 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR937 Gene

Localization for MIR937 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR937 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR937 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR937: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR937 Gene

Pathways & Interactions for MIR937 Gene

genes like me logo Genes that share pathways with MIR937: view

Gene Ontology (GO) - Biological Process for MIR937 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR937: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR937 Gene

Drugs & Compounds for MIR937 Gene

No Compound Related Data Available

Transcripts for MIR937 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR937 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000662FC3_9606 pre_miRNA 86 5

RefSeq: NR_030633,

Ensembl: ENST00000401271 (view in UCSC) ,

miRBase: MI0005759,

Rfam: RF01039,

ENA: LM609992.1:1..86:precursor_RNA,

URS0000553F51_9606 miRNA 22 4

RefSeq: NR_030633,

miRBase: MIMAT0004980,

TarBase: hsa-miR-937-3p,

ENA: LM380527.1:1..22:ncRNA, LM609992.1:51..72:ncRNA,

URS0000776393_9606 miRNA 20 3

RefSeq: NR_030633,

miRBase: MIMAT0022938,

ENA: LM609992.1:14..33:ncRNA,

URS0001BC4E6C_9606 pre_miRNA 86 1

Rfam: RF01039,

MIR937 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR937 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR937 Gene

No ASD Table

Relevant External Links for MIR937 Gene

GeneLoc Exon Structure for
MIR937

Expression for MIR937 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR937 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR937

genes like me logo Genes that share expression patterns with MIR937: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR937 Gene

Orthologs for MIR937 Gene

Evolution for MIR937 Gene

ENSEMBL:
Gene Tree for MIR937 (if available)
TreeFam:
Gene Tree for MIR937 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR937

No data available for Orthologs for MIR937 Gene

Paralogs for MIR937 Gene

No data available for Paralogs for MIR937 Gene

Variants for MIR937 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR937 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs778211172 Likely Benign: not provided 143,812,971(-) G/A
NM_182706.5(SCRIB):c.643-10C>T
NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR937 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR937 Gene

Variant ID Type Subtype PubMed ID
nsv1161815 CNV deletion 26073780
nsv466009 CNV loss 19166990
nsv612895 CNV loss 21841781
nsv612896 CNV loss 21841781
nsv612897 CNV loss 21841781
nsv6442 CNV deletion 18451855
nsv950014 CNV deletion 24416366

Additional Variant Information for MIR937 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR937
Leiden Open Variation Database (LOVD)
MIR937

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR937 Gene

Disorders for MIR937 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR937 Gene - From: COP

Disorder Aliases PubMed IDs
intracranial berry aneurysm
  • familial aneurysmal subarachnoid hemorrhage
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR937

genes like me logo Genes that share disorders with MIR937: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR937 Gene

Publications for MIR937 Gene

  1. MicroRNA-937 is overexpressed and predicts poor prognosis in patients with colon cancer. (PMID: 31856857) Liu H … Yang Y (Diagnostic pathology 2019) 3
  2. Diagnostic Significance of miR-937 in Peripheral Blood Mononuclear Cells of Kawasaki Disease. (PMID: 31710429) Wang Z … Li W (Clinical laboratory 2019) 3
  3. Peripheral Blood miR-937 May Serve as a Biomarker for Metabolic Disorders by Targeting AMPKα. (PMID: 31232032) Yang C … Li J (Clinical laboratory 2019) 3
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  5. miR-937 contributes to the lung cancer cell proliferation by targeting INPP4B. (PMID: 27179609) Zhang L … Xu G (Life sciences 2016) 3

Products for MIR937 Gene

Sources for MIR937 Gene