microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR935 Gene

Subcategory (RNA class) for MIR935 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR935 Gene

  • MicroRNA 935 2 3 5
  • Hsa-Mir-935 2 3
  • Hsa-MiR-935 163 173
  • MIR935 2 5
  • Hsa-Mir-935-V1 178
  • Hsa-Mir-935-V2 178
  • MIMAT0004978 50
  • MI0005757 50
  • MIRN935 3
  • Mir-935 3

External Ids for MIR935 Gene

Previous HGNC Symbols for MIR935 Gene

  • MIRN935

Previous GeneCards Identifiers for MIR935 Gene

  • GC19P059179
  • GC19P054485
  • GC19P053984
  • GC19P054066
  • GC19P054068
  • GC19P054063
  • GC19P054123
  • GC19P053986
  • GC19P054017
  • GC19P054040

Summaries for MIR935 Gene

Entrez Gene Summary for MIR935 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR935 Gene

MIR935 (MicroRNA 935) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Phase 0 - rapid depolarisation and Transmission across Chemical Synapses.

Additional gene information for MIR935 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR935 Gene

Genomics for MIR935 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR935 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR935 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR935 Gene

Genomic Locations for MIR935 Gene
chr19:53,982,307-53,982,397
(GRCh38/hg38)
Size:
91 bases
Orientation:
Plus strand
chr19:54,485,561-54,485,651
(GRCh37/hg19)
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR935 Gene

Genes around MIR935 on UCSC Golden Path with GeneCards custom track
MIR935 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR935 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR935 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR935 Gene

Proteins for MIR935 Gene

Post-translational modifications for MIR935 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR935 Gene

Domains & Families for MIR935 Gene

Gene Families for MIR935 Gene

HGNC:
genes like me logo Genes that share domains with MIR935: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR935 Gene

Function for MIR935 Gene

Gene Ontology (GO) - Molecular Function for MIR935 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 30863112
genes like me logo Genes that share ontologies with MIR935: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR935 Gene

Localization for MIR935 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR935 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR935 Gene

Pathways & Interactions for MIR935 Gene

genes like me logo Genes that share pathways with MIR935: view

Gene Ontology (GO) - Biological Process for MIR935 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032711 negative regulation of interleukin-27 production IDA 30863112
GO:0035195 gene silencing by miRNA IDA 30863112
GO:0045535 negative regulation of interleukin-27 biosynthetic process IDA --
genes like me logo Genes that share ontologies with MIR935: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR935 Gene

Drugs & Compounds for MIR935 Gene

No Compound Related Data Available

Transcripts for MIR935 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR935 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000033EBB8_9606 miRNA 23 6

RefSeq: NR_030632,

LncBase: hsa-miR-935,

miRBase: MIMAT0004978,

MirGeneDB: Hsa-Mir-935-v2_3p,

TarBase: hsa-miR-935,

ENA: LM380526.1:1..23:ncRNA, LM609991.1:56..78:ncRNA,

URS000075D91F_9606 precursor_RNA 91 5

HGNC: 33678,

RefSeq: NR_030632,

Ensembl: ENST00000401179 (view in UCSC) ,

miRBase: MI0005757,

ENA: LM609991.1:1..91:precursor_RNA,

URS0000EFCEA4_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-935-v1, Hsa-Mir-935-v2,

URS0000EFEB6F_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-935-v2_5p,

URS0000EFCD8B_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-935-v1_3p,

MIR935 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR935 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR935 Gene

No ASD Table

Relevant External Links for MIR935 Gene

GeneLoc Exon Structure for
MIR935

Expression for MIR935 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR935 Gene

genes like me logo Genes that share expression patterns with MIR935: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR935 Gene

Orthologs for MIR935 Gene

Evolution for MIR935 Gene

ENSEMBL:
Gene Tree for MIR935 (if available)
TreeFam:
Gene Tree for MIR935 (if available)

No data available for Orthologs for MIR935 Gene

Paralogs for MIR935 Gene

No data available for Paralogs for MIR935 Gene

Variants for MIR935 Gene

Additional dbSNP identifiers (rs#s) for MIR935 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR935 Gene

Variant ID Type Subtype PubMed ID
dgv1815n106 CNV deletion 24896259
esv2718812 CNV deletion 23290073
nsv1063127 CNV gain 25217958
nsv458782 CNV gain 19166990
nsv580110 CNV gain 21841781
nsv580111 CNV loss 21841781
nsv833876 CNV loss 17160897
nsv833877 CNV loss 17160897
nsv953612 CNV deletion 24416366

Additional Variant Information for MIR935 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR935

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR935 Gene

Disorders for MIR935 Gene

Additional Disease Information for MIR935

No disorders were found for MIR935 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR935 Gene

Publications for MIR935 Gene

  1. miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression. (PMID: 26742429) Yan C … Zhou L (Biochemical and biophysical research communications 2016) 2 3
  2. miR-935 promotes gastric cancer cell proliferation by targeting SOX7. (PMID: 27044823) Yang M … Chen L (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 2 3
  3. microRNA-935 is reduced in non-small cell lung cancer tissue, is linked to poor outcome, and acts on signal transduction mediator E2F7 and the AKT pathway. (PMID: 30203720) Wang C … Li S (British journal of biomedical science 2019) 3
  4. MicroRNA-935 acts as a prognostic marker and promotes cell proliferation, migration, and invasion in colorectal cancer. (PMID: 31524145) Huang Y … Li H (Cancer biomarkers : section A of Disease markers 2019) 3
  5. IL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro. (PMID: 30863112) Wang T … Yang J (OncoTargets and therapy 2019) 3

Products for MIR935 Gene

Sources for MIR935 Gene