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Aliases for MIR93 Gene

Subcategory (RNA class) for MIR93 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR93 Gene

  • MicroRNA 93 2 3 5
  • Hsa-Mir-93 3
  • MiR-93 3
  • MIRN93 3
  • MIRN9 3

External Ids for MIR93 Gene

Previous HGNC Symbols for MIR93 Gene

  • MIRN93

Previous GeneCards Identifiers for MIR93 Gene

  • GC07M099537
  • GC07M099692
  • GC07M099694
  • GC07M099697
  • GC07M099720
  • GC07M099742
  • GC07M099785
  • GC07M100094
  • GC07M100101
  • GC07M100105
  • GC07M100109
  • GC07M100111
  • GC07M100121
  • GC07M100138

Summaries for MIR93 Gene

Entrez Gene Summary for MIR93 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR93 Gene

MIR93 (MicroRNA 93) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

fRNAdb sequence ontologies for MIR93 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR93 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR93 Gene

Genomics for MIR93 Gene

GeneHancer (GH) Regulatory Elements for MIR93 Gene

Promoters and enhancers for MIR93 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100040 Enhancer 1 ENCODE dbSUPER 11 +52.1 52149 1.6 PKNOX1 FOXA2 RAD21 THRB TCF12 SCRT2 FOS RCOR1 PAF1 RXRA AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 PILRA GC07P100039
GH07I100061 Enhancer 0.8 ENCODE 11.9 +32.0 32018 0.8 HDAC1 HDGF PKNOX1 TAF9B ARNT TCF12 GATA2 NCOA1 MBD2 NFIC COPS6 MIR25 MIR93 MIR106B MCM7 ZKSCAN1 TRIM4 GC07M100100 PIR44616 ZSCAN21
GH07I100137 Enhancer 0.8 Ensembl ENCODE 10.8 -44.3 -44321 0.8 PKNOX1 CLOCK EBF1 ELF1 FOXA1 GATA3 IKZF1 NFE2 RUNX3 TCF7L2 PVRIG C7orf43 GAL3ST4 GPC2 STAG3 GATS AP4M1 MCM7 MIR106B MIR25
GH07I100044 Enhancer 0.6 ENCODE 11 +49.0 48974 0.2 SMARCA5 CTCF ZNF687 NRF1 MAX SIN3A MNT ELF1 RAD21 GABPA ZKSCAN1 COPS6 MIR25 MIR93 MIR106B MCM7 ZSCAN21 GC07P100039
GH07I100048 Enhancer 0.3 ENCODE 11 +44.9 44924 0 ZNF610 PIR43713 ZSCAN21 ZKSCAN1 COPS6 MIR93 MIR25 MIR106B MCM7 GC07P100039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR93 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR93 Gene

Genomic Locations for MIR93 Gene
chr7:100,093,768-100,093,847
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chr7:99,691,391-99,691,470
(GRCh37/hg19)

Genomic View for MIR93 Gene

Genes around MIR93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR93 Gene

ORGUL Member Location for MIR93 Gene

ORGUL Member Location for MIR93 gene

Proteins for MIR93 Gene

Post-translational modifications for MIR93 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR93 Gene

Domains & Families for MIR93 Gene

Gene Families for MIR93 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR93: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR93 Gene

Function for MIR93 Gene

Gene Ontology (GO) - Molecular Function for MIR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR93: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR93 Gene

Localization for MIR93 Gene

Gene Ontology (GO) - Cellular Components for MIR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR93: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR93 Gene

Pathways & Interactions for MIR93 Gene

genes like me logo Genes that share pathways with MIR93: view

Pathways by source for MIR93 Gene

1 BioSystems pathway for MIR93 Gene

Interacting Proteins for MIR93 Gene

Gene Ontology (GO) - Biological Process for MIR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 18728182
genes like me logo Genes that share ontologies with MIR93: view

No data available for SIGNOR curated interactions for MIR93 Gene

Drugs & Compounds for MIR93 Gene

No Compound Related Data Available

Transcripts for MIR93 Gene

mRNA/cDNA for MIR93 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR93 Gene

No ASD Table

Relevant External Links for MIR93 Gene

GeneLoc Exon Structure for
MIR93
ECgene alternative splicing isoforms for
MIR93

Expression for MIR93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR93 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR93 Gene:

MIR93
genes like me logo Genes that share expression patterns with MIR93: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR93 Gene

Orthologs for MIR93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-93 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-93 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-93 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-93 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir93 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-20a-2 34
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-20a 34
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-20a 34
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-93 34
  • 69 (a)
OneToOne
Species where no ortholog for MIR93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR93 Gene

ENSEMBL:
Gene Tree for MIR93 (if available)
TreeFam:
Gene Tree for MIR93 (if available)

Paralogs for MIR93 Gene

No data available for Paralogs for MIR93 Gene

Variants for MIR93 Gene

Sequence variations from dbSNP and Humsavar for MIR93 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000404937 -- 100,093,901(-) G/A upstream_transcript_variant
rs1001565564 -- 100,095,549(-) T/A upstream_transcript_variant
rs1001912842 -- 100,095,716(-) C/T upstream_transcript_variant
rs1002645151 -- 100,095,414(-) A/T upstream_transcript_variant
rs1004588213 -- 100,095,649(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR93 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781

Additional Variant Information for MIR93 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR93

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR93 Gene

Disorders for MIR93 Gene

Additional Disease Information for MIR93

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR93 Gene

Publications for MIR93 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H … Zheng X (FEBS letters 2005) 1 3 58
  3. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K … Kozu T (Biochemical and biophysical research communications 2004) 1 3 58
  4. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J … Dreyfuss G (RNA (New York, N.Y.) 2003) 1 3 58
  5. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. (PMID: 11914277) Mourelatos Z … Dreyfuss G (Genes & development 2002) 1 3 58

Products for MIR93 Gene

Sources for MIR93 Gene

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