microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR92B Gene

Subcategory (RNA class) for MIR92B Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR92B Gene

  • MicroRNA 92b 2 3 5
  • Hsa-MiR-92b-3p 166 177
  • Hsa-MiR-92b-5p 166 177
  • MIMAT0003218 51
  • MIMAT0004792 51
  • Hsa-Mir-92b 3
  • MI0003560 51
  • Mir-92b 3
  • MIRN92B 3
  • MIR92B 2

External Ids for MIR92B Gene

Previous HGNC Symbols for MIR92B Gene

  • MIRN92B

Previous GeneCards Identifiers for MIR92B Gene

  • GC01U902188
  • GC01P153433
  • GC01P155164

Summaries for MIR92B Gene

Entrez Gene Summary for MIR92B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR92B Gene

MIR92B (MicroRNA 92b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR92B include Coronary Heart Disease 1 and Systemic Lupus Erythematosus.

Additional gene information for MIR92B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR92B Gene

Genomics for MIR92B Gene

GeneHancer (GH) Regulatory Elements for MIR92B Gene

Promoters and enhancers for MIR92B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155191 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.0 25 6.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF TCF12 SIN3A MYC NRF1 POLR2G ENSG00000231064 MUC1 LOC105371450 MIR92B lnc-THBS3-2 GBAP1 CLK2 MSTO2P MSTO1 UBAP2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR92B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR92B Gene

Genomic Locations for MIR92B Gene
chr1:155,195,177-155,195,272
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr1:155,164,968-155,165,063
(GRCh37/hg19)
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR92B Gene

Genes around MIR92B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR92B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR92B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR92B Gene

Proteins for MIR92B Gene

Post-translational modifications for MIR92B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR92B Gene

Domains & Families for MIR92B Gene

Gene Families for MIR92B Gene

genes like me logo Genes that share domains with MIR92B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR92B Gene

Function for MIR92B Gene

Phenotypes From GWAS Catalog for MIR92B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR92B Gene

Localization for MIR92B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR92B gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR92B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR92B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR92B Gene

Pathways & Interactions for MIR92B Gene

PathCards logo

SuperPathways for MIR92B Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR92B Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR92B Gene

Drugs & Compounds for MIR92B Gene

No Compound Related Data Available

Transcripts for MIR92B Gene

mRNA/cDNA for MIR92B Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR92B Gene

No ASD Table

Relevant External Links for MIR92B Gene

GeneLoc Exon Structure for
MIR92B

Expression for MIR92B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR92B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR92B

genes like me logo Genes that share expression patterns with MIR92B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR92B Gene

Orthologs for MIR92B Gene

Evolution for MIR92B Gene

ENSEMBL:
Gene Tree for MIR92B (if available)
TreeFam:
Gene Tree for MIR92B (if available)

No data available for Orthologs for MIR92B Gene

Paralogs for MIR92B Gene

No data available for Paralogs for MIR92B Gene

Variants for MIR92B Gene

Additional dbSNP identifiers (rs#s) for MIR92B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR92B Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781

Additional Variant Information for MIR92B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR92B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR92B Gene

Disorders for MIR92B Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR92B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
coronary heart disease 1
  • coronary heart disease, susceptibility to, 1
systemic lupus erythematosus
  • sle
infratentorial cancer
  • brain neoplasm, infratentorial
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
pancreas disease
  • pancreatic diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR92B

genes like me logo Genes that share disorders with MIR92B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR92B Gene

Publications for MIR92B Gene

  1. MiR-92b targets p57kip2 to modulate the resistance of hepatocellular carcinoma (HCC) to ionizing radiation (IR) -based radiotherapy. (PMID: 30544064) Wang J … Jin J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  2. miR-92b-3p Promotes Colorectal Carcinoma Cell Proliferation, Invasion, and Migration by Inhibiting FBXW7 In Vitro and In Vivo. (PMID: 29638162) Gong L … Wang Z (DNA and cell biology 2018) 3 54
  3. Serum Exosomal MiR-92b-5p as a Potential Biomarker for Acute Heart Failure Caused by Dilated Cardiomyopathy. (PMID: 29719295) Wu T … Yang Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 54
  4. The role of miR-92b in cholangiocarcinoma patients. (PMID: 29749758) Zhou MH … Sun JZ (The International journal of biological markers 2018) 3 54
  5. miR‑92b promotes autophagy and suppresses viability and invasion in breast cancer by targeting EZH2. (PMID: 30066891) Liu F … Geng C (International journal of oncology 2018) 3 54

Products for MIR92B Gene

Sources for MIR92B Gene