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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR92A2 (MicroRNA 92a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR92A2 include T-Cell Lymphoblastic Leukemia/Lymphoma and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ134169 | Enhancer | 0.2 | Ensembl | 600.7 | -0.3 | -287 | 0.2 | MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 ENSG00000283638 CCDC160 GPC3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 20484043 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 18766170 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001937 | NOT negative regulation of endothelial cell proliferation | IDA | 19460962 |
GO:0002675 | positive regulation of acute inflammatory response | ISS | -- |
GO:0008016 | regulation of heart contraction | ISS | -- |
GO:0010628 | positive regulation of gene expression | IMP | 22267480 |
GO:0010629 | negative regulation of gene expression | IMP | 20484043 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00003768C5_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-92a-3p, miRBase: MIMAT0000092, MirGeneDB: Hsa-Mir-92-P1a_3p, Hsa-Mir-92-P1b_3p, TarBase: hsa-miR-92a-3p, ENA: AB176708.1:1804..1825:ncRNA, AF480530.1:1..22:ncRNA, LM378779.1:1..22:ncRNA, LM608181.1:48..69:ncRNA, LM608182.1:48..69:ncRNA, |
URS00002E728C_9606 | precursor_RNA | 75 | 5 |
HGNC: 31644, RefSeq: NR_029509, Ensembl: ENST00000385299 (view in UCSC) , miRBase: MI0000094, ENA: AF480564.1:1..75:misc_RNA, LM608182.1:1..75:precursor_RNA, |
URS0000451A59_9606 | miRNA | 22 | 5 |
RefSeq: NR_029509, LncBase: hsa-miR-92a-2-5p, miRBase: MIMAT0004508, TarBase: hsa-miR-92a-2-5p, |
URS0000657EA4_9606 | precursor_RNA | 80 | 1 |
Rfam: RF00464, |
URS0000EFE2B1_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-92-P1b, |
Disorder | Aliases | PubMed IDs |
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t-cell lymphoblastic leukemia/lymphoma |
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pancreatic cancer |
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prostate cancer |
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gastric cancer |
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progesterone resistance |
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