microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR92A2 Gene

Subcategory (RNA class) for MIR92A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR92A2 Gene

  • MicroRNA 92a-2 2 3 5
  • Hsa-MiR-92a-2-5p 163 173
  • Hsa-MiR-92a-3p 163 173
  • MicroRNA 92-2 2 3
  • Hsa-Mir-92a-2 2 3
  • Hsa-Mir-92-2 2 3
  • MIR92A2 2 5
  • Hsa-Mir-92-P1b 178
  • MIMAT0000092 50
  • MIMAT0004508 50
  • MIRN92A-2 3
  • Mir-92a-2 3
  • MI0000094 50
  • MIRN92-2 3
  • MIRN92A2 3
  • RF00464 168

External Ids for MIR92A2 Gene

Previous HGNC Symbols for MIR92A2 Gene

  • MIRN92-2
  • MIRN92A2

Previous GeneCards Identifiers for MIR92A2 Gene

  • GC0XM133151
  • GC0XM133158
  • GC0XM133305
  • GC0XM133310
  • GC0XM133314
  • GC0XM133318
  • GC0XM133323
  • GC0XM133327
  • GC0XM133331
  • GC0XM133335
  • GC0XM133347
  • GC0XM133372
  • GC0XM134171
  • GC0XM134176
  • GC0XM134221
  • GC0XM134227
  • GC0XM134235
  • GC0XM134215
  • GC0XM134181
  • GC0XM134188
  • GC0XM134194
  • GC0XM134200

Summaries for MIR92A2 Gene

Entrez Gene Summary for MIR92A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR92A2 Gene

MIR92A2 (MicroRNA 92a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR92A2 include T-Cell Lymphoblastic Leukemia/Lymphoma and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR92A2 Gene

  • mir-92 microRNA precursor family

Additional gene information for MIR92A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR92A2 Gene

Genomics for MIR92A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR92A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ134169 Enhancer 0.2 Ensembl 600.7 -0.3 -287 0.2 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 ENSG00000283638 CCDC160 GPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR92A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR92A2 Gene

Genomic Locations for MIR92A2 Gene
chrX:134,169,535-134,169,614
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chrX:133,303,568-133,303,642
(GRCh37/hg19)
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR92A2 Gene

Genes around MIR92A2 on UCSC Golden Path with GeneCards custom track
MIR92A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR92A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR92A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR92A2 Gene

Proteins for MIR92A2 Gene

Post-translational modifications for MIR92A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR92A2 Gene

Domains & Families for MIR92A2 Gene

Gene Families for MIR92A2 Gene

genes like me logo Genes that share domains with MIR92A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR92A2 Gene

Function for MIR92A2 Gene

Gene Ontology (GO) - Molecular Function for MIR92A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20484043
genes like me logo Genes that share ontologies with MIR92A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR92A2 Gene

Localization for MIR92A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR92A2 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR92A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR92A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR92A2 Gene

Pathways & Interactions for MIR92A2 Gene

PathCards logo

SuperPathways for MIR92A2 Gene

genes like me logo Genes that share pathways with MIR92A2: view

Pathways by source for MIR92A2 Gene

1 BioSystems pathway for MIR92A2 Gene
1 KEGG pathway for MIR92A2 Gene

Gene Ontology (GO) - Biological Process for MIR92A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 NOT negative regulation of endothelial cell proliferation IDA 19460962
GO:0002675 positive regulation of acute inflammatory response ISS --
GO:0008016 regulation of heart contraction ISS --
GO:0010628 positive regulation of gene expression IMP 22267480
GO:0010629 negative regulation of gene expression IMP 20484043
genes like me logo Genes that share ontologies with MIR92A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR92A2 Gene

Drugs & Compounds for MIR92A2 Gene

No Compound Related Data Available

Transcripts for MIR92A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR92A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003768C5_9606 miRNA 22 6

RefSeq: NR_029508, NR_029509,

LncBase: hsa-miR-92a-3p,

miRBase: MIMAT0000092,

MirGeneDB: Hsa-Mir-92-P1a_3p, Hsa-Mir-92-P1b_3p,

TarBase: hsa-miR-92a-3p,

ENA: AB176708.1:1804..1825:ncRNA, AF480530.1:1..22:ncRNA, LM378779.1:1..22:ncRNA, LM608181.1:48..69:ncRNA, LM608182.1:48..69:ncRNA,

URS00002E728C_9606 precursor_RNA 75 5

HGNC: 31644,

RefSeq: NR_029509,

Ensembl: ENST00000385299 (view in UCSC) ,

miRBase: MI0000094,

ENA: AF480564.1:1..75:misc_RNA, LM608182.1:1..75:precursor_RNA,

URS0000451A59_9606 miRNA 22 5

RefSeq: NR_029509,

LncBase: hsa-miR-92a-2-5p,

miRBase: MIMAT0004508,

TarBase: hsa-miR-92a-2-5p,

ENA: LM380187.1:1..22:ncRNA, LM608182.1:9..30:ncRNA,

URS0000657EA4_9606 precursor_RNA 80 1

Rfam: RF00464,

URS0000EFE2B1_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-92-P1b,

MIR92A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR92A2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR92A2 Gene

No ASD Table

Relevant External Links for MIR92A2 Gene

GeneLoc Exon Structure for
MIR92A2

Expression for MIR92A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR92A2

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR92A2 Gene

Orthologs for MIR92A2 Gene

Evolution for MIR92A2 Gene

ENSEMBL:
Gene Tree for MIR92A2 (if available)
TreeFam:
Gene Tree for MIR92A2 (if available)

No data available for Orthologs for MIR92A2 Gene

Paralogs for MIR92A2 Gene

No data available for Paralogs for MIR92A2 Gene

Variants for MIR92A2 Gene

Additional dbSNP identifiers (rs#s) for MIR92A2 Gene

Additional Variant Information for MIR92A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR92A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR92A2 Gene

Disorders for MIR92A2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR92A2 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
pancreatic cancer
  • pancreatic carcinoma
prostate cancer
  • prostate cancer, somatic
gastric cancer
  • gastric cancer, somatic
progesterone resistance
  • pseudocorpus luteum insufficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR92A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR92A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR92A2 Gene

Publications for MIR92A2 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. Plasma Hsa-miR-92a-3p in correlation with lipocalin-2 is associated with sepsis-induced coagulopathy. (PMID: 32075600) Wang Y … Tong Z (BMC infectious diseases 2020) 3
  3. miR-92a promotes progesterone resistance in endometriosis through PTEN/AKT pathway. (PMID: 31863773) Li M … Sun P (Life sciences 2020) 3
  4. Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells. (PMID: 31500278) Yamada NO … Senda T (International journal of molecular sciences 2019) 3
  5. CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. (PMID: 31064356) Hu JL … Liang L (Molecular cancer 2019) 3

Products for MIR92A2 Gene

Sources for MIR92A2 Gene