microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR92A1 Gene

Subcategory (RNA class) for MIR92A1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR92A1 Gene

  • MicroRNA 92a-1 2 3 5
  • Hsa-MiR-92a-1-5p 163 173
  • Hsa-MiR-92a-3p 163 173
  • MicroRNA 92-1 2 3
  • Hsa-Mir-92a-1 2 3
  • Hsa-Mir-92-1 2 3
  • MIR92A1 2 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-92-P1a 178
  • MIMAT0004507 50
  • MIMAT0000092 50
  • MIRN92A-1 3
  • MiRNA92-1 3
  • Mir-92a-1 3
  • MI0000093 50
  • C13orf25 3
  • MIRN92-1 3
  • MIRN92A1 3
  • MIR17HG 3
  • MIR92-1 3
  • RF00464 168
  • MIRHG1 3
  • MIRH1 3

External Ids for MIR92A1 Gene

Previous HGNC Symbols for MIR92A1 Gene

  • MIRN92-1
  • MIRN92A1

Previous GeneCards Identifiers for MIR92A1 Gene

  • GC13P090874
  • GC13P090882
  • GC13P092013
  • GC13P092022
  • GC13P092029
  • GC13P092037
  • GC13P092046
  • GC13P092056
  • GC13P092065
  • GC13P092075
  • GC13P092083
  • GC13P092096
  • GC13P092109
  • GC13P091355
  • GC13P091361
  • GC13P091378
  • GC13P091384
  • GC13P091385
  • GC13P091420
  • GC13P091369
  • GC13P091348
  • GC13P091366
  • GC13P091367
  • GC13P091370
  • GC13P091372
  • GC13P091377

Summaries for MIR92A1 Gene

Entrez Gene Summary for MIR92A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR92A1 Gene

MIR92A1 (MicroRNA 92a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR92A1 include Leukemia, Chronic Lymphocytic and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR92A1 Gene

  • mir-92 microRNA precursor family

Additional gene information for MIR92A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR92A1 Gene

Genomics for MIR92A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR92A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J091346 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.3 -2313 5.2 GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1
GH13J091353 Enhancer 0.4 Ensembl 0.7 +2.6 2587 1 POLR2A NR2F2 NFATC1 ZNF362 MIR92A1 MIR17HG LOC107984617 GPC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR92A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR92A1 Gene

Genomic Locations for MIR92A1 Gene
chr13:91,351,314-91,351,391
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr13:92,000,074-92,006,833
(GRCh37/hg19)
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR92A1 Gene

Genes around MIR92A1 on UCSC Golden Path with GeneCards custom track
MIR92A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR92A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR92A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR92A1 Gene

Proteins for MIR92A1 Gene

Post-translational modifications for MIR92A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR92A1 Gene

Domains & Families for MIR92A1 Gene

Gene Families for MIR92A1 Gene

genes like me logo Genes that share domains with MIR92A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR92A1 Gene

Function for MIR92A1 Gene

Gene Ontology (GO) - Molecular Function for MIR92A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20484043
genes like me logo Genes that share ontologies with MIR92A1: view

Animal Model Products

CRISPR Products

miRNA for MIR92A1 Gene

miRTarBase miRNAs that target MIR92A1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR92A1 Gene

Localization for MIR92A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR92A1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR92A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0005737 cytoplasm IDA 25336585
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR92A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR92A1 Gene

Pathways & Interactions for MIR92A1 Gene

genes like me logo Genes that share pathways with MIR92A1: view

Pathways by source for MIR92A1 Gene

1 KEGG pathway for MIR92A1 Gene

Gene Ontology (GO) - Biological Process for MIR92A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 NOT negative regulation of endothelial cell proliferation IDA 19460962
GO:0002675 positive regulation of acute inflammatory response ISS --
GO:0008016 regulation of heart contraction ISS --
GO:0010628 positive regulation of gene expression IMP 22267480
GO:0010629 negative regulation of gene expression IMP 20484043
genes like me logo Genes that share ontologies with MIR92A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR92A1 Gene

Drugs & Compounds for MIR92A1 Gene

No Compound Related Data Available

Transcripts for MIR92A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR92A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002B6637_9606 precursor_RNA 78 6

HGNC: 31643,

RefSeq: NR_029508,

Ensembl: ENST00000385233 (view in UCSC) ,

miRBase: MI0000093,

Rfam: RF00464,

ENA: AB176708.1:1757..1834:ncRNA, AF480563.1:1..78:misc_RNA, LM608181.1:1..78:precursor_RNA,

URS00001DA458_9606 miRNA 23 6

RefSeq: NR_029508,

LncBase: hsa-miR-92a-1-5p,

miRBase: MIMAT0004507,

MirGeneDB: Hsa-Mir-92-P1a_5p,

TarBase: hsa-miR-92a-1-5p,

ENA: LM380186.1:1..23:ncRNA, LM608181.1:11..33:ncRNA,

URS00003768C5_9606 miRNA 22 6

RefSeq: NR_029508, NR_029509,

LncBase: hsa-miR-92a-3p,

miRBase: MIMAT0000092,

MirGeneDB: Hsa-Mir-92-P1a_3p, Hsa-Mir-92-P1b_3p,

TarBase: hsa-miR-92a-3p,

ENA: AB176708.1:1804..1825:ncRNA, AF480530.1:1..22:ncRNA, LM378779.1:1..22:ncRNA, LM608181.1:48..69:ncRNA, LM608182.1:48..69:ncRNA,

URS0000EFEE66_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-92-P1a,

MIR92A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR92A1 Gene

4 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR92A1 Gene

No ASD Table

Relevant External Links for MIR92A1 Gene

GeneLoc Exon Structure for
MIR92A1

Expression for MIR92A1 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR92A1 Gene

Orthologs for MIR92A1 Gene

Evolution for MIR92A1 Gene

ENSEMBL:
Gene Tree for MIR92A1 (if available)
TreeFam:
Gene Tree for MIR92A1 (if available)

No data available for Orthologs for MIR92A1 Gene

Paralogs for MIR92A1 Gene

No data available for Paralogs for MIR92A1 Gene

Variants for MIR92A1 Gene

Additional dbSNP identifiers (rs#s) for MIR92A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR92A1 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Additional Variant Information for MIR92A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR92A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR92A1 Gene

Disorders for MIR92A1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for MIR92A1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
pancreatic cancer
  • pancreatic carcinoma
feingold syndrome 1
  • fglds1
rapidly progressive glomerulonephritis
  • glomerulonephritis rapidly progressive
malignant ovarian surface epithelial-stromal neoplasm
  • malignant ovarian surface epithelial-stromal tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR92A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR92A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR92A1 Gene

Publications for MIR92A1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
  3. Plasma Hsa-miR-92a-3p in correlation with lipocalin-2 is associated with sepsis-induced coagulopathy. (PMID: 32075600) Wang Y … Tong Z (BMC infectious diseases 2020) 3
  4. miR-92a promotes progesterone resistance in endometriosis through PTEN/AKT pathway. (PMID: 31863773) Li M … Sun P (Life sciences 2020) 3
  5. MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. (PMID: 30816508) Wang Z … Zhang X (Molecular medicine reports 2019) 3

Products for MIR92A1 Gene

Sources for MIR92A1 Gene