microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR921 Gene

Subcategory (RNA class) for MIR921 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR921 Gene

  • MicroRNA 921 2 3 5
  • Hsa-Mir-921 2 3
  • Hsa-MiR-921 163 173
  • MIR921 2 5
  • MIMAT0004971 50
  • MI0005713 50
  • MIRN921 3

External Ids for MIR921 Gene

Previous HGNC Symbols for MIR921 Gene

  • MIRN921

Previous GeneCards Identifiers for MIR921 Gene

  • GC01M164392
  • GC01M166123

Summaries for MIR921 Gene

Entrez Gene Summary for MIR921 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR921 Gene

MIR921 (MicroRNA 921) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR921 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR921 Gene

Genomics for MIR921 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR921 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J166153 Enhancer 0.3 Ensembl 600.7 +0.9 897 1 POLR2A SMARCA4 MIR921 piR-37123 FAM78B ENSG00000230898 piR-54758 TMCO1
GH01J166089 Enhancer 0.5 Ensembl 10.4 +64.6 64597 0.8 ZNF143 RAD21 CTCF ELF1 MYNN SMARCA5 HLF ZNF687 piR-40916 ENSG00000230898 FAM78B MIR921 RF00017-381 FAM78B-AS1 TMCO1
GH01J166086 Enhancer 0.5 Ensembl 10.4 +68.3 68297 0.6 DPF2 RELB IKZF1 NR2F1 ESRRA ETV6 ENSG00000230898 FAM78B MIR921 piR-40916 RF00017-381 FAM78B-AS1 TMCO1
GH01J166185 Enhancer 0.3 Ensembl ENCODE 10.4 -30.5 -30502 1 MIR921 ENSG00000229588 FAM78B LOC112268276 piR-47086-016 POGK
GH01J166122 Enhancer 0.3 Ensembl 11.5 +31.8 31797 0.8 POLR2A FAM78B MIR921 ENSG00000230898 FAM78B-AS1 piR-54758 piR-57195-020 TMCO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR921 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR921 Gene

Genomic Locations for MIR921 Gene
chr1:166,154,743-166,154,798
(GRCh38/hg38)
Size:
56 bases
Orientation:
Minus strand
chr1:166,123,980-166,124,035
(GRCh37/hg19)
Size:
56 bases
Orientation:
Minus strand

Genomic View for MIR921 Gene

Genes around MIR921 on UCSC Golden Path with GeneCards custom track
MIR921 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR921 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR921 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR921 Gene

Proteins for MIR921 Gene

Post-translational modifications for MIR921 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR921 Gene

Domains & Families for MIR921 Gene

Gene Families for MIR921 Gene

HGNC:
genes like me logo Genes that share domains with MIR921: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR921 Gene

Function for MIR921 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR921 Gene

Localization for MIR921 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR921 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR921 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR921: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR921 Gene

Pathways & Interactions for MIR921 Gene

PathCards logo

SuperPathways for MIR921 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR921 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR921 Gene

Drugs & Compounds for MIR921 Gene

No Compound Related Data Available

Transcripts for MIR921 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR921 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C577_9606 precursor_RNA 56 4

HGNC: 33671,

RefSeq: NR_030626,

Ensembl: ENST00000401133 (view in UCSC) ,

miRBase: MI0005713,

URS0000759CD8_9606 miRNA 25 4

RefSeq: NR_030626,

LncBase: hsa-miR-921,

miRBase: MIMAT0004971,

TarBase: hsa-miR-921,

MIR921 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR921 Gene

No ASD Table

Relevant External Links for MIR921 Gene

GeneLoc Exon Structure for
MIR921

No data available for mRNA/cDNA for MIR921 Gene

Expression for MIR921 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR921

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR921 Gene

Orthologs for MIR921 Gene

Evolution for MIR921 Gene

ENSEMBL:
Gene Tree for MIR921 (if available)
TreeFam:
Gene Tree for MIR921 (if available)

No data available for Orthologs for MIR921 Gene

Paralogs for MIR921 Gene

No data available for Paralogs for MIR921 Gene

Variants for MIR921 Gene

Additional dbSNP identifiers (rs#s) for MIR921 Gene

Additional Variant Information for MIR921 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR921

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR921 Gene

Disorders for MIR921 Gene

Additional Disease Information for MIR921

No disorders were found for MIR921 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR921 Gene

Publications for MIR921 Gene

  1. MiR-921 directly downregulates GPx3 in A549 lung cancer cells. (PMID: 30898707) Choi JY … Lee SW (Gene 2019) 3
  2. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  3. MicroRNAs differentially regulate carbonyl reductase 1 (CBR1) gene expression dependent on the allele status of the common polymorphic variant rs9024. (PMID: 23133646) Kalabus JL … Blanco JG (PloS one 2012) 3
  4. Analysis of gene expression in normal and neoplastic human testis: new roles of RNA. (PMID: 17573847) Novotny GW … Leffers H (International journal of andrology 2007) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR921 Gene

Sources for MIR921 Gene