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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR920 (MicroRNA 920) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J024252 | Enhancer | 0.8 | UCNEbase Ensembl | 10.2 | +40.8 | 40780 | 2.4 | PRDM1 POLR2A ZNF384 GATA2 | MIR920 lnc-LRMP-10 SOX5-AS1 L13714-078 SOX5 lnc-SOX5-5 | |
GH12J024238 | Enhancer | 0.3 | Ensembl | 11 | +26.9 | 26880 | 2.6 | PRDM1 | MIR920 lnc-LRMP-10 SOX5-AS1 SOX5 lnc-SOX5-5 | |
GH12J024245 | Enhancer | 0.3 | ENCODE | 11 | +32.6 | 32611 | 0 | FOS | MIR920 lnc-LRMP-10 SOX5-AS1 SOX5 lnc-SOX5-5 | |
GH12J024244 | Enhancer | 0.3 | Ensembl | 11 | +32.2 | 32180 | 0.8 | FOS | MIR920 lnc-LRMP-10 SOX5-AS1 SOX5 lnc-SOX5-5 | |
GH12J024349 | Enhancer | 0.3 | Ensembl | 10.4 | +137.1 | 137080 | 1.8 | JUN | MIR920 piR-33270-008 L13714-078 SOX5 lnc-SOX5-5 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 28915828 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA, IEA | -- |
GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | IDA | 28915828 |
GO:0045415 | negative regulation of interleukin-8 biosynthetic process | IDA | 28915828 |
GO:0050724 | negative regulation of interleukin-1 beta biosynthetic process | IDA | 28915828 |
GO:0050728 | negative regulation of inflammatory response | IDA | 28915828 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000067E0B9_9606 | precursor_RNA | 75 | 5 |
HGNC: 33670, RefSeq: NR_030625, Ensembl: ENST00000401373 (view in UCSC) , miRBase: MI0005712, Rfam: RF00986, |
URS000075EE93_9606 | miRNA | 20 | 4 |
RefSeq: NR_030625, LncBase: hsa-miR-920, miRBase: MIMAT0004970, TarBase: hsa-miR-920, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-920 31 |
|
OneToOne |
No disorders were found for MIR920 Gene.