microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR9-2 Gene

Subcategory (RNA class) for MIR9-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR9-2 Gene

  • MIMAT0000441 50
  • MIMAT0000442 50
  • MI0000467 50
  • MiRNA9-2 3
  • MIRN9-2 3
  • Mir-9-2 3
  • RF00237 168

External Ids for MIR9-2 Gene

Previous HGNC Symbols for MIR9-2 Gene

  • MIRN9-2

Previous GeneCards Identifiers for MIR9-2 Gene

  • GC05M088001
  • GC05M087962
  • GC05M087805
  • GC05M088508

Summaries for MIR9-2 Gene

Entrez Gene Summary for MIR9-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR9-2 Gene

MIR9-2 (MicroRNA 9-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR9-2 include Oral Squamous Cell Carcinoma and Glioma Susceptibility 1. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR9-2 Gene

  • mir-9/mir-79 microRNA precursor family

Additional gene information for MIR9-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR9-2 Gene

Genomics for MIR9-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR9-2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR9-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR9-2 Gene

Genomic Locations for MIR9-2 Gene
chr5:88,666,853-88,666,939
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr5:87,803,363-87,986,858
(GRCh37/hg19)
Size:
183,496 bases
Orientation:
Minus strand

Genomic View for MIR9-2 Gene

Genes around MIR9-2 on UCSC Golden Path with GeneCards custom track
MIR9-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR9-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR9-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR9-2 Gene

Proteins for MIR9-2 Gene

Post-translational modifications for MIR9-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR9-2 Gene

Domains & Families for MIR9-2 Gene

Gene Families for MIR9-2 Gene

genes like me logo Genes that share domains with MIR9-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR9-2 Gene

Function for MIR9-2 Gene

Phenotypes From GWAS Catalog for MIR9-2 Gene

Gene Ontology (GO) - Molecular Function for MIR9-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 23985560
GO:0008035 high-density lipoprotein particle binding ISS --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25809226
genes like me logo Genes that share ontologies with MIR9-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR9-2 Gene

Localization for MIR9-2 Gene

Gene Ontology (GO) - Cellular Components for MIR9-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23985560
GO:0005737 cytoplasm IDA 23985560
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR9-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR9-2 Gene

Pathways & Interactions for MIR9-2 Gene

PathCards logo

SuperPathways for MIR9-2 Gene

genes like me logo Genes that share pathways with MIR9-2: view

Pathways by source for MIR9-2 Gene

1 BioSystems pathway for MIR9-2 Gene
1 KEGG pathway for MIR9-2 Gene

Gene Ontology (GO) - Biological Process for MIR9-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion ISS --
GO:0008285 negative regulation of cell proliferation IDA 25809226
GO:0030336 negative regulation of cell migration IDA 25809226
GO:0031047 gene silencing by RNA IDA 23985560
GO:0033689 negative regulation of osteoblast proliferation ISS --
genes like me logo Genes that share ontologies with MIR9-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR9-2 Gene

Drugs & Compounds for MIR9-2 Gene

No Compound Related Data Available

Transcripts for MIR9-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR9-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004208C5_9606 miRNA 23 6

RefSeq: NR_029691, NR_029692, NR_030741,

LncBase: hsa-miR-9-5p,

miRBase: MIMAT0000441,

MirGeneDB: Hsa-Mir-9-P1_5p, Hsa-Mir-9-P2_5p, Hsa-Mir-9-P3_5p,

TarBase: hsa-miR-9-5p,

ENA: LM379059.1:1..23:ncRNA, LM608506.1:16..38:ncRNA, LM608507.1:16..38:ncRNA, LM608508.1:16..38:ncRNA,

URS00003496BE_9606 miRNA 22 6

RefSeq: NR_029691, NR_029692, NR_030741,

LncBase: hsa-miR-9-3p,

miRBase: MIMAT0000442,

MirGeneDB: Hsa-Mir-9-P1_3p, Hsa-Mir-9-P2_3p, Hsa-Mir-9-P3_3p,

TarBase: hsa-miR-9-3p,

ENA: LM379060.1:1..22:ncRNA, LM608506.1:55..76:ncRNA, LM608507.1:53..74:ncRNA, LM608508.1:55..76:ncRNA,

URS00003FA6CD_9606 precursor_RNA 87 5

HGNC: 31642,

RefSeq: NR_030741,

Ensembl: ENST00000384838 (view in UCSC) ,

miRBase: MI0000467,

ENA: LM608507.1:1..87:precursor_RNA,

URS00002A6B75_9606 precursor_RNA 60 1

Rfam: RF00237,

URS0000EFE40E_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-9-P2,

MIR9-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR9-2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR9-2 Gene

No ASD Table

Relevant External Links for MIR9-2 Gene

GeneLoc Exon Structure for
MIR9-2

Expression for MIR9-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR9-2

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR9-2 Gene

Orthologs for MIR9-2 Gene

Evolution for MIR9-2 Gene

ENSEMBL:
Gene Tree for MIR9-2 (if available)
TreeFam:
Gene Tree for MIR9-2 (if available)

No data available for Orthologs for MIR9-2 Gene

Paralogs for MIR9-2 Gene

No data available for Paralogs for MIR9-2 Gene

Variants for MIR9-2 Gene

Additional dbSNP identifiers (rs#s) for MIR9-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR9-2 Gene

Variant ID Type Subtype PubMed ID
nsv524630 CNV loss 19592680

Additional Variant Information for MIR9-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR9-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR9-2 Gene

Disorders for MIR9-2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR9-2 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
glioma susceptibility 1
  • glm1
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR9-2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR9-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR9-2 Gene

Publications for MIR9-2 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9. (PMID: 31432701) Deng W … Wang Y (Artificial cells, nanomedicine, and biotechnology 2019) 3
  3. Down-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells. (PMID: 30803553) Park YR … Kim SW (Cancer genetics 2019) 3
  4. Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication. (PMID: 31597449) Chang YJ … Chien S (Arteriosclerosis, thrombosis, and vascular biology 2019) 3
  5. MicroRNA-9 enhanced radiosensitivity and its mechanism of DNA methylation in non-small cell lung cancer. (PMID: 31158449) Wei W … Jin SZ (Gene 2019) 3

Products for MIR9-2 Gene

Sources for MIR9-2 Gene