microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR9-1 Gene

Subcategory (RNA class) for MIR9-1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR9-1 Gene

  • MicroRNA 9-1 2 3 5
  • Hsa-MiR-9-5p 163 173
  • Hsa-MiR-9-3p 163 173
  • Hsa-Mir-9-1 2 3
  • MIR9-1 2 5
  • MIMAT0000441 50
  • Hsa-Mir-9-P1 178
  • MIMAT0000442 50
  • MI0000466 50
  • MiRNA9-1 3
  • MIRN9-1 3
  • Mir-9-1 3
  • RF00237 168

External Ids for MIR9-1 Gene

Previous HGNC Symbols for MIR9-1 Gene

  • MIRN9-1

Previous GeneCards Identifiers for MIR9-1 Gene

  • GC01M154657
  • GC01M156390

Summaries for MIR9-1 Gene

Entrez Gene Summary for MIR9-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR9-1 Gene

MIR9-1 (MicroRNA 9-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR9-1 include Oral Squamous Cell Carcinoma and Schizophrenia. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.

Rfam classification for MIR9-1 Gene

  • mir-9/mir-79 microRNA precursor family

Additional gene information for MIR9-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR9-1 Gene

Genomics for MIR9-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR9-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR9-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR9-1 Gene

Genomic Locations for MIR9-1 Gene
chr1:156,420,341-156,420,429
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand
chr1:156,390,133-156,390,221
(GRCh37/hg19)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR9-1 Gene

Genes around MIR9-1 on UCSC Golden Path with GeneCards custom track
MIR9-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR9-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR9-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR9-1 Gene

Proteins for MIR9-1 Gene

Post-translational modifications for MIR9-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR9-1 Gene

Domains & Families for MIR9-1 Gene

Gene Families for MIR9-1 Gene

genes like me logo Genes that share domains with MIR9-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR9-1 Gene

Function for MIR9-1 Gene

Phenotypes From GWAS Catalog for MIR9-1 Gene

Gene Ontology (GO) - Molecular Function for MIR9-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003727 single-stranded RNA binding IDA 23985560
GO:0008035 high-density lipoprotein particle binding ISS --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25809226
genes like me logo Genes that share ontologies with MIR9-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR9-1 Gene

Localization for MIR9-1 Gene

Gene Ontology (GO) - Cellular Components for MIR9-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23985560
GO:0005737 cytoplasm IDA 23985560
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR9-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR9-1 Gene

Pathways & Interactions for MIR9-1 Gene

genes like me logo Genes that share pathways with MIR9-1: view

Pathways by source for MIR9-1 Gene

2 BioSystems pathways for MIR9-1 Gene
1 KEGG pathway for MIR9-1 Gene

Gene Ontology (GO) - Biological Process for MIR9-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion ISS --
GO:0008285 negative regulation of cell proliferation IDA 25809226
GO:0030336 negative regulation of cell migration IDA 25809226
GO:0031047 gene silencing by RNA IDA 23985560
GO:0033689 negative regulation of osteoblast proliferation ISS --
genes like me logo Genes that share ontologies with MIR9-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR9-1 Gene

Drugs & Compounds for MIR9-1 Gene

No Compound Related Data Available

Transcripts for MIR9-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR9-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004208C5_9606 miRNA 23 6

RefSeq: NR_029691, NR_029692, NR_030741,

LncBase: hsa-miR-9-5p,

miRBase: MIMAT0000441,

MirGeneDB: Hsa-Mir-9-P1_5p, Hsa-Mir-9-P2_5p, Hsa-Mir-9-P3_5p,

TarBase: hsa-miR-9-5p,

ENA: LM379059.1:1..23:ncRNA, LM608506.1:16..38:ncRNA, LM608507.1:16..38:ncRNA, LM608508.1:16..38:ncRNA,

URS00003496BE_9606 miRNA 22 6

RefSeq: NR_029691, NR_029692, NR_030741,

LncBase: hsa-miR-9-3p,

miRBase: MIMAT0000442,

MirGeneDB: Hsa-Mir-9-P1_3p, Hsa-Mir-9-P2_3p, Hsa-Mir-9-P3_3p,

TarBase: hsa-miR-9-3p,

ENA: LM379060.1:1..22:ncRNA, LM608506.1:55..76:ncRNA, LM608507.1:53..74:ncRNA, LM608508.1:55..76:ncRNA,

URS000075C54E_9606 precursor_RNA 89 5

HGNC: 31641,

RefSeq: NR_029691,

Ensembl: ENST00000385198 (view in UCSC) ,

miRBase: MI0000466,

ENA: LM608506.1:1..89:precursor_RNA,

URS0000634891_9606 precursor_RNA 62 1

Rfam: RF00237,

URS0000EFC850_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-9-P1,

MIR9-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR9-1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR9-1 Gene

No ASD Table

Relevant External Links for MIR9-1 Gene

GeneLoc Exon Structure for
MIR9-1

Expression for MIR9-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR9-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR9-1

genes like me logo Genes that share expression patterns with MIR9-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR9-1 Gene

Orthologs for MIR9-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR9-1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-9-1 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-9-1 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm25641 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-9a-3 31
  • 65 (a)
ManyToMany
mdo-mir-9b 31
  • 50 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-9-1 31
  • 46 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 93 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-9-2 31
  • 76 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-9-1 31
  • 68 (a)
ManyToMany
dre-mir-9-4 31
  • 64 (a)
ManyToMany
Species where no ortholog for MIR9-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR9-1 Gene

ENSEMBL:
Gene Tree for MIR9-1 (if available)
TreeFam:
Gene Tree for MIR9-1 (if available)

Paralogs for MIR9-1 Gene

No data available for Paralogs for MIR9-1 Gene

Variants for MIR9-1 Gene

Additional dbSNP identifiers (rs#s) for MIR9-1 Gene

Additional Variant Information for MIR9-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR9-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR9-1 Gene

Disorders for MIR9-1 Gene

MalaCards: The human disease database

(143) MalaCards diseases for MIR9-1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
schizophrenia
  • sczd
epithelioid cell melanoma
  • epithelioid melanoma
central nervous system cancer
  • central nervous system tumor
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR9-1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR9-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR9-1 Gene

Publications for MIR9-1 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis. (PMID: 32267380) Coêlho MC … Oliveira NFP (Journal of applied oral science : revista FOB 2020) 3
  3. Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9. (PMID: 31432701) Deng W … Wang Y (Artificial cells, nanomedicine, and biotechnology 2019) 3
  4. DKK1 expression is suppressed by miR-9 during induced dopaminergic differentiation of human trabecular meshwork mesenchymal stem cells. (PMID: 31173848) Mirfazeli ES … Zeynali B (Neuroscience letters 2019) 3
  5. Down-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells. (PMID: 30803553) Park YR … Kim SW (Cancer genetics 2019) 3

Products for MIR9-1 Gene

Sources for MIR9-1 Gene