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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR9-1 Gene
Subcategory (RNA class) for MIR9-1 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR9-1 Gene
External Ids for MIR9-1 Gene
- HGNC: 31641
- Entrez Gene: 407046
- Ensembl: ENSG00000207933
- OMIM: 611186
- miRBase: hsa-mir-9-1
Previous HGNC Symbols for MIR9-1 Gene
- MIRN9-1
Previous GeneCards Identifiers for MIR9-1 Gene
- GC01M154657
- GC01M156390
Summaries for MIR9-1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR9-1 Gene
MIR9-1 (MicroRNA 9-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR9-1 include Oral Squamous Cell Carcinoma and Schizophrenia. Among its related pathways are Cell Differentiation - Index and MicroRNAs in cancer.
Rfam classification for MIR9-1 Gene
-
mir-9/mir-79 microRNA precursor family
Additional gene information for MIR9-1 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR9-1 Gene
Genomics for MIR9-1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR9-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR9-1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR9-1 Gene
Genomic Locations for MIR9-1 Gene
- chr1:156,420,341-156,420,429
- (GRCh38/hg38)
- Size:
- 89 bases
- Orientation:
- Minus strand
- chr1:156,390,133-156,390,221
- (GRCh37/hg19)
- Size:
- 89 bases
- Orientation:
- Minus strand
Genomic View for MIR9-1 Gene
Genes around MIR9-1 on UCSC Golden Path with GeneCards custom track
MIR9-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1q22 by HGNC
- 1q22 by Entrez Gene
- 1q22 by Ensembl
MIR9-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR9-1 Gene
Proteins for MIR9-1 Gene
Post-translational modifications for MIR9-1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR9-1
- Origene Custom Protein Services for MIR9-1
No data available for DME Specific Peptides for MIR9-1 Gene
Domains & Families for MIR9-1 Gene
Gene Families for MIR9-1 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR9-1 Gene
Function for MIR9-1 Gene
Phenotypes From GWAS Catalog for MIR9-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003727 | single-stranded RNA binding | IDA | 23985560 |
| GO:0008035 | high-density lipoprotein particle binding | ISS | -- |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25809226 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR9-1 - Select products 50% OFF >
- * MIR9-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR9-1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR9-1 - Select products 50% OFF >
- * MIR9-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR9-1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR9-1 Gene
Localization for MIR9-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 23985560 |
| GO:0005737 | cytoplasm | IDA | 23985560 |
| GO:0070062 | extracellular exosome | ISS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR9-1 Gene
Pathways & Interactions for MIR9-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Alzheimers Disease | ||
| 3 | Cell Differentiation - Index | ||
Pathways by source for MIR9-1 Gene
2 BioSystems pathways for MIR9-1 Gene
1 KEGG pathway for MIR9-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | ISS | -- |
| GO:0008285 | negative regulation of cell proliferation | IDA | 25809226 |
| GO:0030336 | negative regulation of cell migration | IDA | 25809226 |
| GO:0031047 | gene silencing by RNA | IDA | 23985560 |
| GO:0033689 | negative regulation of osteoblast proliferation | ISS | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR9-1 Gene
Transcripts for MIR9-1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR9-1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00004208C5_9606 | miRNA | 23 | 6 |
RefSeq: NR_029691, NR_029692, NR_030741, LncBase: hsa-miR-9-5p, miRBase: MIMAT0000441, MirGeneDB: Hsa-Mir-9-P1_5p, Hsa-Mir-9-P2_5p, Hsa-Mir-9-P3_5p, TarBase: hsa-miR-9-5p, ENA: LM379059.1:1..23:ncRNA, LM608506.1:16..38:ncRNA, LM608507.1:16..38:ncRNA, LM608508.1:16..38:ncRNA, |
| URS00003496BE_9606 | miRNA | 22 | 6 |
RefSeq: NR_029691, NR_029692, NR_030741, LncBase: hsa-miR-9-3p, miRBase: MIMAT0000442, MirGeneDB: Hsa-Mir-9-P1_3p, Hsa-Mir-9-P2_3p, Hsa-Mir-9-P3_3p, TarBase: hsa-miR-9-3p, ENA: LM379060.1:1..22:ncRNA, LM608506.1:55..76:ncRNA, LM608507.1:53..74:ncRNA, LM608508.1:55..76:ncRNA, |
| URS000075C54E_9606 | precursor_RNA | 89 | 5 |
HGNC: 31641, RefSeq: NR_029691, Ensembl: ENST00000385198 (view in UCSC) , miRBase: MI0000466, |
| URS0000634891_9606 | precursor_RNA | 62 | 1 |
Rfam: RF00237, |
| URS0000EFC850_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-9-P1, |
MIR9-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR9-1 Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR9-1 - Select products 50% OFF >
- * MIR9-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR9-1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR9-1 - Select products 50% OFF >
- * MIR9-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR9-1
Relevant External Links for MIR9-1 Gene
- GeneLoc Exon Structure for
- MIR9-1
Expression for MIR9-1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR9-1
Primer Products
-
OriGene qPCR primer pairs for MIR9-1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR9-1 Gene
Orthologs for MIR9-1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | cfa-mir-9-1 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-9-1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm25641 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-9a-3 31 |
|
ManyToMany | |
| mdo-mir-9b 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-9-1 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-9-2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-9-1 31 |
|
ManyToMany | |
| dre-mir-9-4 31 |
|
ManyToMany |
- Species where no ortholog for MIR9-1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR9-1 Gene
No data available for Paralogs for MIR9-1 Gene
Variants for MIR9-1 Gene
Additional Variant Information for MIR9-1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR9-1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR9-1 Gene
Disorders for MIR9-1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oral squamous cell carcinoma |
|
|
| schizophrenia |
|
|
| epithelioid cell melanoma |
|
|
| central nervous system cancer |
|
|
| autonomic nervous system neoplasm |
|
|
Search MIR9-1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR9-1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR9-1 Gene
Publications for MIR9-1 Gene
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
- miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis. (PMID: 32267380) Coêlho MC … Oliveira NFP (Journal of applied oral science : revista FOB 2020) 3
- Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9. (PMID: 31432701) Deng W … Wang Y (Artificial cells, nanomedicine, and biotechnology 2019) 3
- DKK1 expression is suppressed by miR-9 during induced dopaminergic differentiation of human trabecular meshwork mesenchymal stem cells. (PMID: 31173848) Mirfazeli ES … Zeynali B (Neuroscience letters 2019) 3
- Down-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells. (PMID: 30803553) Park YR … Kim SW (Cancer genetics 2019) 3
ExternalLinks
Products for MIR9-1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR9-1
- Origene Custom Protein Services for MIR9-1
- Browse OriGene Inhibitory RNA Products For MIR9-1
- OriGene qPCR primer pairs for MIR9-1
- Browse CRISPR knockouts for MIR9-1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR9-1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR9-1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR9-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR9-1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR9-1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR9-1
Sources for MIR9-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB