microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR889 Gene

Subcategory (RNA class) for MIR889 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR889 Gene

  • MicroRNA 889 2 3 5
  • Hsa-Mir-889 2 3
  • MIR889 2 5
  • Hsa-Mir-154-P27 178
  • Hsa-MiR-889-3p 173
  • MIMAT0004921 50
  • MIMAT0026719 50
  • MI0005540 50
  • MIRN889 3
  • Mir-889 3
  • RF00641 168

External Ids for MIR889 Gene

Previous HGNC Symbols for MIR889 Gene

  • MIRN889

Previous GeneCards Identifiers for MIR889 Gene

  • GC14P100827
  • GC14P100917
  • GC14P101518
  • GC14P101547
  • GC14P101581
  • GC14P101621
  • GC14P101649
  • GC14P101682
  • GC14P101720
  • GC14P101762
  • GC14P101820
  • GC14P101960
  • GC14P102157
  • GC14P101259
  • GC14P101870
  • GC14P103649
  • GC14P103868
  • GC14P104144
  • GC14P104486
  • GC14P102189
  • GC14P102358
  • GC14P102528
  • GC14P102708
  • GC14P102881
  • GC14P103053
  • GC14P103249
  • GC14P103465

Summaries for MIR889 Gene

Entrez Gene Summary for MIR889 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR889 Gene

MIR889 (MicroRNA 889) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR889 Gene

Additional gene information for MIR889 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR889 Gene

Genomics for MIR889 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR889 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR889 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR889 Gene

Genomic Locations for MIR889 Gene
chr14:101,047,900-101,047,979
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr14:101,514,238-101,514,316
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR889 Gene

Genes around MIR889 on UCSC Golden Path with GeneCards custom track
MIR889 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR889 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR889 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR889 Gene

Proteins for MIR889 Gene

Post-translational modifications for MIR889 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR889 Gene

Domains & Families for MIR889 Gene

Gene Families for MIR889 Gene

HGNC:
genes like me logo Genes that share domains with MIR889: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR889 Gene

Function for MIR889 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR889 Gene

Localization for MIR889 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR889 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR889 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR889: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR889 Gene

Pathways & Interactions for MIR889 Gene

PathCards logo

SuperPathways for MIR889 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR889 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR889: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR889 Gene

Drugs & Compounds for MIR889 Gene

No Compound Related Data Available

Transcripts for MIR889 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR889 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D4A4_9606 precursor_RNA 79 5

HGNC: 33651,

RefSeq: NR_030595,

Ensembl: ENST00000401280 (view in UCSC) ,

miRBase: MI0005540,

ENA: LM609948.1:1..79:precursor_RNA,

URS000045B99E_9606 miRNA 21 5

RefSeq: NR_030595,

miRBase: MIMAT0004921,

MirGeneDB: Hsa-Mir-154-P27_3p,

TarBase: hsa-miR-889-3p,

ENA: LM380486.1:1..21:ncRNA, LM609948.1:49..69:ncRNA,

URS000075AAF0_9606 miRNA 22 4

RefSeq: NR_030595,

miRBase: MIMAT0026719,

MirGeneDB: Hsa-Mir-154-P27_5p,

ENA: LM609948.1:11..32:ncRNA,

URS000072370A_9606 precursor_RNA 79 1

Rfam: RF00641,

URS0000EFE303_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-154-P27,

MIR889 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR889 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR889 Gene

No ASD Table

Relevant External Links for MIR889 Gene

GeneLoc Exon Structure for
MIR889

Expression for MIR889 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR889 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR889

genes like me logo Genes that share expression patterns with MIR889: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR889 Gene

Orthologs for MIR889 Gene

Evolution for MIR889 Gene

ENSEMBL:
Gene Tree for MIR889 (if available)
TreeFam:
Gene Tree for MIR889 (if available)

No data available for Orthologs for MIR889 Gene

Paralogs for MIR889 Gene

No data available for Paralogs for MIR889 Gene

Variants for MIR889 Gene

Additional dbSNP identifiers (rs#s) for MIR889 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR889 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR889 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR889

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR889 Gene

Disorders for MIR889 Gene

Additional Disease Information for MIR889

No disorders were found for MIR889 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR889 Gene

Publications for MIR889 Gene

  1. ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer. (PMID: 31115539) Dong Z … Wang X (Molecular medicine reports 2019) 3
  2. The mechanism of miR-889 regulates osteogenesis in human bone marrow mesenchymal stem cells. (PMID: 31727100) Xu G … Shi HF (Journal of orthopaedic surgery and research 2019) 3
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  4. miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. (PMID: 25841337) Xu Y … Sun F (FEBS letters 2015) 3
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3

Products for MIR889 Gene

Sources for MIR889 Gene