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Aliases for MIR873 Gene

Subcategory (RNA class) for MIR873 Gene


Quality Score for this RNA gene is


Aliases for MIR873 Gene

  • MicroRNA 873 2 3 5
  • Hsa-Mir-873 3
  • Mir-873 3
  • MIRN873 3

External Ids for MIR873 Gene

Previous HGNC Symbols for MIR873 Gene

  • MIRN873

Summaries for MIR873 Gene

Entrez Gene Summary for MIR873 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR873 Gene

MIR873 (MicroRNA 873) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinsons Disease Pathway.

Additional gene information for MIR873 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR873 Gene

Genomics for MIR873 Gene

GeneHancer (GH) Regulatory Elements for MIR873 Gene

Promoters and enhancers for MIR873 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I028915 Enhancer 0.6 ENCODE 0.3 -26.7 -26684 0.7 JUN CEBPB EP300 BRCA1 RFX5 SP1 JUND MAFF ATF3 ZBTB33 LINGO2 MIR873 GC09P029173
GH09I028927 Enhancer 0.6 ENCODE 0.3 -38.9 -38943 0.2 JUN CEBPB EP300 RAD21 RFX5 SP1 JUND GATA3 STAT3 FOS MIR873 GC09P029173 LINGO2
GH09I028925 Enhancer 0.6 ENCODE 0.3 -36.5 -36521 0.3 STAT1 JUN CEBPB EP300 ZKSCAN1 JUND POLR2A STAT3 RCOR1 CHD2 ENSG00000260412 LINGO2 MIR873 GC09P029173
GH09I028969 Enhancer 0.7 ENCODE dbSUPER 0.2 -81.7 -81728 2.9 CTCF SP1 USF1 POLR2A POU5F1 LINGO2 MIR873 GC09P029173
GH09I028923 Enhancer 0.3 ENCODE 0.3 -34.6 -34563 0.2 EZH2 MIR873 GC09P029173 LINGO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR873 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR873 Gene

Genomic Locations for MIR873 Gene
77 bases
Minus strand

Genomic View for MIR873 Gene

Genes around MIR873 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR873 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR873 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR873 Gene

ORGUL Member Location for MIR873 Gene

ORGUL Member Location for MIR873 gene

Proteins for MIR873 Gene

Post-translational modifications for MIR873 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR873 Gene

Domains & Families for MIR873 Gene

Gene Families for MIR873 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR873: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR873 Gene

Function for MIR873 Gene

Phenotypes From GWAS Catalog for MIR873 Gene

Gene Ontology (GO) - Molecular Function for MIR873 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28583401
genes like me logo Genes that share ontologies with MIR873: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR873 Gene

Localization for MIR873 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR873 Gene

Pathways & Interactions for MIR873 Gene

genes like me logo Genes that share pathways with MIR873: view

Pathways by source for MIR873 Gene

2 BioSystems pathways for MIR873 Gene

Interacting Proteins for MIR873 Gene

Gene Ontology (GO) - Biological Process for MIR873 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 28583401
GO:0060044 negative regulation of cardiac muscle cell proliferation IDA 28583401
GO:1902807 negative regulation of cell cycle G1/S phase transition IDA 28583401
genes like me logo Genes that share ontologies with MIR873: view

No data available for SIGNOR curated interactions for MIR873 Gene

Drugs & Compounds for MIR873 Gene

No Compound Related Data Available

Transcripts for MIR873 Gene

mRNA/cDNA for MIR873 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR873 Gene

No ASD Table

Relevant External Links for MIR873 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR873 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR873 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR873 Gene:

genes like me logo Genes that share expression patterns with MIR873: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR873 Gene

Orthologs for MIR873 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR873 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-873 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-873 34
  • 97 (a)
(Mus musculus)
Mammalia Mir873 34
  • 95 (a)
(Monodelphis domestica)
Mammalia mdo-mir-873 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-873 34
  • 86 (a)
Species where no ortholog for MIR873 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR873 Gene

Gene Tree for MIR873 (if available)
Gene Tree for MIR873 (if available)

Paralogs for MIR873 Gene

No data available for Paralogs for MIR873 Gene

Variants for MIR873 Gene

Sequence variations from dbSNP and Humsavar for MIR873 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001175947 -- 28,888,734(-) C/G downstream_transcript_variant
rs1002444324 -- 28,889,641(-) A/G upstream_transcript_variant
rs1002851211 -- 28,890,060(-) A/G upstream_transcript_variant
rs1002904060 -- 28,889,839(-) T/C upstream_transcript_variant
rs1003455795 -- 28,890,722(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR873 Gene

Variant ID Type Subtype PubMed ID
nsv471296 CNV loss 18288195
nsv1020624 CNV loss 25217958
dgv7498n100 CNV loss 25217958
dgv12628n54 CNV loss 21841781

Additional Variant Information for MIR873 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR873 Gene

Disorders for MIR873 Gene

Additional Disease Information for MIR873

No disorders were found for MIR873 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR873 Gene

Publications for MIR873 Gene

  1. miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1. (PMID: 28583401) Zhang JS … Qiu GR (Gene 2017) 3 58
  2. Elevated expression of microRNA-873 facilitates Th17 differentiation by targeting forkhead box O1 (Foxo1) in the pathogenesis of systemic lupus erythematosus. (PMID: 28837808) Liu L … Sun H (Biochemical and biophysical research communications 2017) 3 58
  3. MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1. (PMID: 26850595) Wu DD … Zong ZH (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  4. MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells. (PMID: 25531331) Cui J … Zhang C (Oncogene 2015) 3 58
  5. MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1. (PMID: 25670861) Wang RJ … Liang HQ (The Journal of biological chemistry 2015) 3 58

Products for MIR873 Gene

Sources for MIR873 Gene

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