microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR8058 Gene

Subcategory (RNA class) for MIR8058 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR8058 Gene

  • MicroRNA 8058 2 3 5
  • MicroRNA Mir-8058 3
  • Hsa-Mir-8058 3
  • MIMAT0030985 53
  • MI0025894 53
  • MIR8058 2

External Ids for MIR8058 Gene

Previous GeneCards Identifiers for MIR8058 Gene

  • GC16U901683

Summaries for MIR8058 Gene

Entrez Gene Summary for MIR8058 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR8058 Gene

MIR8058 (MicroRNA 8058) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR8058 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR8058 Gene

Genomics for MIR8058 Gene

GeneHancer (GH) Regulatory Elements for MIR8058 Gene

Promoters and enhancers for MIR8058 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J082698 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 +11.7 11670 4.8 FOXA1 SP1 FOXA2 CEBPB JUN JUND MAX EP300 FOS STAT3 CDH13 MIR8058 ENSG00000280044
GH16J082651 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 0.3 -34.3 -34273 6.9 ZNF24 SP1 POLR2A JUND ETV6 RELA MLLT1 ZNF687 CREM ZBED1 CDH13 5MWI_A-068 MIR8058
GH16J082693 Enhancer 0.6 Ensembl ENCODE 0.4 +5.6 5570 2.6 ATF7 FOS JUND ATF2 MIR8058 ENSG00000280044 CDH13
GH16J082659 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 0.3 -28.0 -28022 2.5 PKNOX1 RUNX3 CDH13 PLCG2 5MWI_A-068 MIR8058
GH16J082682 Enhancer 0.4 Ensembl ENCODE 0.4 -5.8 -5816 1 NR2F2 MIR8058 5MWI_A-068 CDH13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR8058 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR8058 Gene

Genomic Locations for MIR8058 Gene
chr16:82,688,931-82,689,019
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR8058 Gene

Genes around MIR8058 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR8058 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR8058 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR8058 Gene

Proteins for MIR8058 Gene

Post-translational modifications for MIR8058 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR8058 Gene

Domains & Families for MIR8058 Gene

Gene Families for MIR8058 Gene

HGNC:
genes like me logo Genes that share domains with MIR8058: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR8058 Gene

Function for MIR8058 Gene

Phenotypes From GWAS Catalog for MIR8058 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR8058 Gene

Localization for MIR8058 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR8058 Gene

Pathways & Interactions for MIR8058 Gene

PathCards logo

SuperPathways for MIR8058 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR8058 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR8058 Gene

Drugs & Compounds for MIR8058 Gene

No Compound Related Data Available

Transcripts for MIR8058 Gene

mRNA/cDNA for MIR8058 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR8058 Gene

No ASD Table

Relevant External Links for MIR8058 Gene

GeneLoc Exon Structure for
MIR8058
ECgene alternative splicing isoforms for
MIR8058

Expression for MIR8058 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR8058 Gene:

MIR8058
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR8058 Gene

Orthologs for MIR8058 Gene

Evolution for MIR8058 Gene

ENSEMBL:
Gene Tree for MIR8058 (if available)
TreeFam:
Gene Tree for MIR8058 (if available)

No data available for Orthologs for MIR8058 Gene

Paralogs for MIR8058 Gene

No data available for Paralogs for MIR8058 Gene

Variants for MIR8058 Gene

Sequence variations from dbSNP and Humsavar for MIR8058 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000137682 -- 82,688,014(+) C/A upstream_transcript_variant
rs1000474038 -- 82,687,310(+) C/T upstream_transcript_variant
rs1000831052 -- 82,687,916(+) C/T upstream_transcript_variant
rs1001597577 -- 82,687,784(+) A/G upstream_transcript_variant
rs1001628573 -- 82,687,579(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR8058 Gene

Variant ID Type Subtype PubMed ID
dgv3051n100 CNV gain 25217958
dgv5253n54 CNV gain 21841781
esv2751616 CNV gain 17911159
esv3892916 CNV loss 25118596
esv3892917 CNV loss 25118596
nsv1059718 CNV loss 25217958
nsv1061288 CNV gain+loss 25217958
nsv1065896 CNV gain 25217958
nsv526366 CNV loss 19592680
nsv527828 CNV loss 19592680
nsv573367 CNV gain 21841781
nsv573371 CNV loss 21841781
nsv573379 CNV gain 21841781

Additional Variant Information for MIR8058 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR8058

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR8058 Gene

Disorders for MIR8058 Gene

Additional Disease Information for MIR8058

No disorders were found for MIR8058 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR8058 Gene

Publications for MIR8058 Gene

  1. Characterization and Identification of novel serum microRNAs in sepsis patients with different outcomes. (PMID: 23612084) Wang HJ … Xie LX (Shock (Augusta, Ga.) 2013) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR8058 Gene

Sources for MIR8058 Gene