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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR8058 (MicroRNA 8058) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J082698 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 0.4 | +11.7 | 11670 | 4.8 | JUND CEBPB FOXA2 JUN FOS FOSL1 MAX EP300 CEBPG ZNF335 | CDH13 MIR8058 ENSG00000280044 | |
GH16J082651 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 0.3 | -34.3 | -34273 | 6.9 | SP1 POLR2A BACH1 JUND ZNF143 RELA TCF12 IKZF2 RCOR1 TRIM22 | CDH13 5MWI_A-063 MIR8058 | |
GH16J082693 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +5.6 | 5570 | 2.6 | ATF7 FOS MAFK JUND ATF2 | MIR8058 ENSG00000280044 CDH13 | |
GH16J082659 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 0.3 | -28.0 | -28022 | 2.5 | PKNOX1 RUNX3 | CDH13 PLCG2 5MWI_A-063 MIR8058 | |
GH16J082682 | Enhancer | 0.4 | Ensembl ENCODE | 0.4 | -5.8 | -5816 | 1 | NR2F2 | MIR8058 5MWI_A-063 CDH13 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BACA_9606 | precursor_RNA | 89 | 4 |
HGNC: 50018, RefSeq: NR_107025, Ensembl: ENST00000615737 (view in UCSC) , miRBase: MI0025894, |
URS000075E3DD_9606 | miRNA | 22 | 2 |
RefSeq: NR_107025, miRBase: MIMAT0030985, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3051n100 | CNV | gain | 25217958 |
dgv5253n54 | CNV | gain | 21841781 |
esv2751616 | CNV | gain | 17911159 |
esv3892916 | CNV | loss | 25118596 |
esv3892917 | CNV | loss | 25118596 |
nsv1059718 | CNV | loss | 25217958 |
nsv1061288 | CNV | gain+loss | 25217958 |
nsv1065896 | CNV | gain | 25217958 |
nsv526366 | CNV | loss | 19592680 |
nsv527828 | CNV | loss | 19592680 |
nsv573367 | CNV | gain | 21841781 |
nsv573371 | CNV | loss | 21841781 |
nsv573379 | CNV | gain | 21841781 |
No disorders were found for MIR8058 Gene.