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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR8058 (MicroRNA 8058) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J082698 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 0.4 | +11.5 | 11470 | 4.4 | CEBPB ZNF395 MAX VEZF1 EP300 FOXA2 STAT3 JUND TBP FOSL1 | CDH13 MIR8058 ENSG00000280044 lnc-HSD17B2-6 | |
GH16J082651 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 0.3 | -34.3 | -34273 | 6.9 | SP1 BCL11A CEBPA POLR2A CEBPB FOXA2 IRF4 TRIM22 EP300 GABPA | CDH13 5MWI_A-062 MIR8058 | |
GH16J082693 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +5.6 | 5570 | 1.8 | MAFK JUND ATF2 ATF7 | MIR8058 lnc-HSD17B2-6 ENSG00000280044 CDH13 | |
GH16J082659 | Enhancer | 0.7 | FANTOM5 ENCODE dbSUPER | 0.3 | -28.0 | -28022 | 2.5 | RUNX3 | CDH13 PLCG2 5MWI_A-062 MIR8058 | |
GH16J082671 | Enhancer | 0.5 | Ensembl dbSUPER | 0.4 | -16.8 | -16830 | 0.2 | CTCF SMC3 | 5MWI_A-062 MIR8058 CDH13 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BACA_9606 | pre_miRNA | 89 | 3 |
RefSeq: NR_107025, Ensembl: ENST00000615737 (view in UCSC) , miRBase: MI0025894, |
URS000075E3DD_9606 | miRNA | 22 | 2 |
RefSeq: NR_107025, miRBase: MIMAT0030985, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3051n100 | CNV | gain | 25217958 |
dgv5253n54 | CNV | gain | 21841781 |
esv2751616 | CNV | gain | 17911159 |
esv3892916 | CNV | loss | 25118596 |
esv3892917 | CNV | loss | 25118596 |
nsv1059718 | CNV | loss | 25217958 |
nsv1061288 | CNV | gain+loss | 25217958 |
nsv1065896 | CNV | gain | 25217958 |
nsv526366 | CNV | loss | 19592680 |
nsv527828 | CNV | loss | 19592680 |
nsv573367 | CNV | gain | 21841781 |
nsv573371 | CNV | loss | 21841781 |
nsv573379 | CNV | gain | 21841781 |
No disorders were found for MIR8058 Gene.