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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR7974 (MicroRNA 7974) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J011496 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 600.7 | -1.7 | -1679 | 2.2 | CTCF ZBTB33 PRDM10 ZNF629 IKZF1 JUND REST RAD21 DPF2 ZNF600 | MIR7974 ZNF653 ECSIT ENSG00000267477 lnc-ECSIT-1 ELAVL3 | |
GH19J011489 | Enhancer | 1.1 | FANTOM5 ENCODE | 0.7 | +5.0 | 4957 | 1.9 | GATAD2A TFE3 SIX5 ZNF143 RXRB IRF2 SP1 GABPA ZKSCAN8 FOXA2 | ZNF491 ZNF441 MIR7974 ELAVL3 lnc-ELAVL3-1 ENSG00000267477 ZNF653 | |
GH19J011478 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE | 0.4 | +14.4 | 14421 | 4 | ZNF221 SP1 CREB1 CTCF TEAD4 PRDM10 ZNF629 REST TFE3 RFX1 | ELAVL3 lnc-ELAVL3-1 ILF3 KRI1 ZNF136 ZNF627 TIMM29 ZNF44 ZNF441 ZNF625 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C799_9606 | precursor_RNA | 79 | 4 |
HGNC: 49992, RefSeq: NR_107014, Ensembl: ENST00000615835 (view in UCSC) , miRBase: MI0025750, |
URS000075E96D_9606 | miRNA | 24 | 3 |
RefSeq: NR_107014, LncBase: hsa-miR-7974, miRBase: MIMAT0031177, |
No disorders were found for MIR7974 Gene.