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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR7846 (MicroRNA 7846) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Apoptosis Modulation and Signaling and Interleukin-4 and 13 signaling.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J012165 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 600.7 | -1.4 | -1443 | 0.3 | IKZF1 STAT1 | TNFRSF1B MIR7846 MTHFR CLCN6 TNFRSF8 AGTRAP MFN2 lnc-KIAA2013-6 | |
GH01J012166 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | +10.1 | 10068 | 21.6 | CREB1 HNRNPL REST ZNF629 ZNF512 LEF1 IKZF1 KDM1A POLR2A BACH1 | TNFRSF1B MTHFR TNFRSF8 CLCN6 VPS13D AGTRAP MIIP MFN2 lnc-TNFRSF8-2 MIR4632 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Cytokine Signaling in Immune system | ||
3 | Apoptosis Modulation and Signaling |
.41
|
|
4 | Interleukin-10 signaling | ||
5 | Interleukin-4 and 13 signaling |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A795_9606 | precursor_RNA | 96 | 4 |
HGNC: 50029, RefSeq: NR_107000, Ensembl: ENST00000622420 (view in UCSC) , miRBase: MI0025516, |
URS000075B936_9606 | miRNA | 21 | 2 |
RefSeq: NR_107000, miRBase: MIMAT0030421, |
No disorders were found for MIR7846 Gene.