microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR770 Gene

Subcategory (RNA class) for MIR770 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR770 Gene

  • MicroRNA 770 2 3 5
  • Hsa-Mir-770 2 3 178
  • Hsa-MiR-770-5p 163 173
  • MIR770 2 5
  • MIMAT0003948 50
  • MI0005118 50
  • MIRN770 3
  • RF00888 168

External Ids for MIR770 Gene

Previous HGNC Symbols for MIR770 Gene

  • MIRN770

Previous GeneCards Identifiers for MIR770 Gene

  • GC14P100389
  • GC14P101318
  • GC14P101215
  • GC14P101796
  • GC14P103647
  • GC14P103867
  • GC14P104143
  • GC14P104485
  • GC14P102089
  • GC14P102323
  • GC14P102494
  • GC14P102669
  • GC14P102842
  • GC14P103015
  • GC14P103213
  • GC14P103464

Summaries for MIR770 Gene

Entrez Gene Summary for MIR770 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR770 Gene

MIR770 (MicroRNA 770) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR770 include Gastric Cardia Adenocarcinoma and Cardia Cancer.

Rfam classification for MIR770 Gene

Additional gene information for MIR770 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR770 Gene

Genomics for MIR770 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR770 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR770 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR770 Gene

Genomic Locations for MIR770 Gene
chr14:100,852,389-100,852,487
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr14:101,318,727-101,318,824
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR770 Gene

Genes around MIR770 on UCSC Golden Path with GeneCards custom track
MIR770 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR770 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR770 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR770 Gene

Proteins for MIR770 Gene

Post-translational modifications for MIR770 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR770 Gene

Domains & Families for MIR770 Gene

Gene Families for MIR770 Gene

HGNC:
genes like me logo Genes that share domains with MIR770: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR770 Gene

Function for MIR770 Gene

Phenotypes From GWAS Catalog for MIR770 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR770 Gene

Localization for MIR770 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR770 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR770 Gene

Pathways & Interactions for MIR770 Gene

PathCards logo

SuperPathways for MIR770 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR770: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR770 Gene

Drugs & Compounds for MIR770 Gene

No Compound Related Data Available

Transcripts for MIR770 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR770 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BA84_9606 precursor_RNA 98 4

HGNC: 33143,

RefSeq: NR_030528,

Ensembl: ENST00000390219 (view in UCSC) ,

miRBase: MI0005118,

URS000075A169_9606 miRNA 23 4

RefSeq: NR_030528,

LncBase: hsa-miR-770-5p,

miRBase: MIMAT0003948,

TarBase: hsa-miR-770-5p,

URS00006F7B40_9606 precursor_RNA 98 1

Rfam: RF00888,

URS0000EFDAFB_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-770,

URS0000EFD7FA_9606 miRNA 25 1

MirGeneDB: Hsa-Mir-770_5p,

MIR770 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR770 Gene

No ASD Table

Relevant External Links for MIR770 Gene

GeneLoc Exon Structure for
MIR770

No data available for mRNA/cDNA for MIR770 Gene

Expression for MIR770 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR770 Gene

mRNA differential expression in normal tissues according to GTEx for MIR770 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Pituitary (x5.7), and Brain - Cerebellar Hemisphere (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR770

genes like me logo Genes that share expression patterns with MIR770: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR770 Gene

Orthologs for MIR770 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR770 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-770 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir770 31
  • 73 (a)
OneToOne
Species where no ortholog for MIR770 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR770 Gene

ENSEMBL:
Gene Tree for MIR770 (if available)
TreeFam:
Gene Tree for MIR770 (if available)

Paralogs for MIR770 Gene

No data available for Paralogs for MIR770 Gene

Variants for MIR770 Gene

Additional dbSNP identifiers (rs#s) for MIR770 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR770 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635518 CNV gain 21293372
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv832876 CNV loss 17160897

Additional Variant Information for MIR770 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR770

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR770 Gene

Disorders for MIR770 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR770 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
cardia cancer
  • ca cardia - stomach
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR770: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR770 Gene

Publications for MIR770 Gene

  1. Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase. (PMID: 28333152) Lee HC … Lee JS (Cell death & disease 2017) 2 3
  2. Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma. (PMID: 26602384) Wu WJ … Wu ZX (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 2 3
  3. Involvement of miR-770-5p in trastuzumab response in HER2 positive breast cancer cells. (PMID: 31009516) Noyan S … Gur Dedeoglu B (PloS one 2019) 3
  4. Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes. (PMID: 29453204) Satake E … Krolewski AS (Diabetes 2018) 3
  5. MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1. (PMID: 29323124) Li Y … Yang Q (Cell death & disease 2018) 3

Products for MIR770 Gene

Sources for MIR770 Gene