microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR769 Gene

Subcategory (RNA class) for MIR769 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR769 Gene

  • MIMAT0003886 50
  • MIMAT0003887 50
  • MI0003834 50
  • MIRN769 3
  • Mir-769 3

External Ids for MIR769 Gene

Previous HGNC Symbols for MIR769 Gene

  • MIRN769

Previous GeneCards Identifiers for MIR769 Gene

  • GC19P051215
  • GC19P046522

Summaries for MIR769 Gene

Entrez Gene Summary for MIR769 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR769 Gene

MIR769 (MicroRNA 769) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR769 include Systemic Lupus Erythematosus. Among its related pathways are Alzheimers Disease.

Additional gene information for MIR769 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR769 Gene

Genomics for MIR769 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR769 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046020 Enhancer 0.6 Ensembl 600.7 +1.5 1478 1.2 JUND ZNF639 MYNN ZBTB17 FOSL1 DPF2 ADNP ATF3 GLIS1 FOS MIR769 PGLYRP1 CCDC61
GH19J046263 Enhancer 1.1 Ensembl ENCODE 11.1 +244.2 244169 1.8 SP1 PRDM10 ZNF629 ZNF692 POLR2A ZNF174 ZNF300 PATZ1 IKZF2 ZNF311 IRF2BP1 ZC3H4 CCDC61 PPP5D1 ENSG00000269124 NOVA2 ENSG00000268810 PNMA8A HIF3A IGFL4
GH19J045952 Enhancer 0.9 ENCODE 11.3 -64.2 -64160 4.5 ZBTB33 ZNF629 REST TFE3 RFX1 NFKBIZ RFX5 ZNF692 GABPA ZNF143 CCDC61 MYPOP MIR769 PGLYRP1 FOXA3 SYMPK IGFL4 HIF3A DMWD ERCC1
GH19J046065 Enhancer 0.8 Ensembl ENCODE 11.5 +47.1 47069 1.6 BDP1 CEBPB JUN JUND CUX1 GATA3 POLR3A DPF2 STAT1 STAT3 IRF2BP1 PPP1R37 ENSG00000268810 PGLYRP1 MIR769 PPP5C HIF3A ENSG00000268460 piR-42317 lnc-CCDC61-4
GH19J046258 Enhancer 0.7 Ensembl 11.1 +240.4 240385 1.1 ZNF512 PRDM1 SCRT2 MGA ZXDB CTBP1 FOXA2 ZBTB17 FOSL1 FOSL2 IGFL1P2 lnc-IGFL3-6 piR-34822-163 HIF3A IGFL4 PGLYRP1 MIR769 CCDC61 NOVA2 HSALNG0126659
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR769 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR769 Gene

Genomic Locations for MIR769 Gene
chr19:46,018,932-46,019,049
(GRCh38/hg38)
Size:
118 bases
Orientation:
Plus strand
chr19:46,522,190-46,522,307
(GRCh37/hg19)
Size:
118 bases
Orientation:
Plus strand

Genomic View for MIR769 Gene

Genes around MIR769 on UCSC Golden Path with GeneCards custom track
MIR769 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR769 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR769 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR769 Gene

Proteins for MIR769 Gene

Post-translational modifications for MIR769 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR769 Gene

Domains & Families for MIR769 Gene

Gene Families for MIR769 Gene

HGNC:
genes like me logo Genes that share domains with MIR769: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR769 Gene

Function for MIR769 Gene

Animal Model Products

CRISPR Products

miRNA for MIR769 Gene

miRTarBase miRNAs that target MIR769

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR769 Gene

Localization for MIR769 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR769 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR769 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR769: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR769 Gene

Pathways & Interactions for MIR769 Gene

PathCards logo

SuperPathways for MIR769 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR769: view

Pathways by source for MIR769 Gene

1 BioSystems pathway for MIR769 Gene

Gene Ontology (GO) - Biological Process for MIR769 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR769 Gene

Drugs & Compounds for MIR769 Gene

No Compound Related Data Available

Transcripts for MIR769 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR769 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004E008F_9606 miRNA 22 6

RefSeq: NR_030412,

LncBase: hsa-miR-769-5p,

miRBase: MIMAT0003886,

MirGeneDB: Hsa-Mir-769_5p,

TarBase: hsa-miR-769-5p,

ENA: LM380030.1:1..22:ncRNA, LM609635.1:30..51:ncRNA,

URS000075D819_9606 precursor_RNA 118 5

HGNC: 33138,

RefSeq: NR_030412,

Ensembl: ENST00000390225 (view in UCSC) ,

miRBase: MI0003834,

ENA: LM609635.1:1..118:precursor_RNA,

URS00005F5472_9606 miRNA 23 5

RefSeq: NR_030412,

LncBase: hsa-miR-769-3p,

miRBase: MIMAT0003887,

TarBase: hsa-miR-769-3p,

ENA: LM380031.1:1..23:ncRNA, LM609635.1:69..91:ncRNA,

URS0000EFC77D_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-769,

URS0000EFBEF7_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-769_3p,

MIR769 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR769 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR769 Gene

No ASD Table

Relevant External Links for MIR769 Gene

GeneLoc Exon Structure for
MIR769

Expression for MIR769 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR769 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR769

genes like me logo Genes that share expression patterns with MIR769: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR769 Gene

Orthologs for MIR769 Gene

Evolution for MIR769 Gene

ENSEMBL:
Gene Tree for MIR769 (if available)
TreeFam:
Gene Tree for MIR769 (if available)

No data available for Orthologs for MIR769 Gene

Paralogs for MIR769 Gene

No data available for Paralogs for MIR769 Gene

Variants for MIR769 Gene

Additional dbSNP identifiers (rs#s) for MIR769 Gene

Additional Variant Information for MIR769 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR769

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR769 Gene

Disorders for MIR769 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR769 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR769: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR769 Gene

Publications for MIR769 Gene

  1. MiR-769 promoted cell proliferation in human melanoma by suppressing GSK3B expression. (PMID: 27470346) Qiu HJ … Chen FC (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 2 3
  2. MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation. (PMID: 25081069) Luo EC … Lai LC (Scientific reports 2014) 2 3
  3. Long Noncoding RNA LINC00460 Promotes the Gefitinib Resistance of Nonsmall Cell Lung Cancer Through Epidermal Growth Factor Receptor by Sponging miR-769-5p. (PMID: 30601026) Ma G … Yang Y (DNA and cell biology 2019) 3
  4. MicroRNA-769-5p contributes to the proliferation, migration and invasion of hepatocellular carcinoma cells by attenuating RYBP. (PMID: 31545279) Xian Y … Tu K (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. Characterization of a novel panel of plasma microRNAs that discriminates between Mycobacterium tuberculosis infection and healthy individuals. (PMID: 28910318) Cui JY … Ling H (PloS one 2017) 3

Products for MIR769 Gene

Sources for MIR769 Gene