microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR766 Gene

Subcategory (RNA class) for MIR766 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR766 Gene

  • MicroRNA 766 2 3 5
  • Hsa-MiR-766-3p 166 177
  • Hsa-MiR-766-5p 166 177
  • MIMAT0003888 51
  • MIMAT0022714 51
  • Hsa-Mir-766 3
  • MI0003836 51
  • Mir-766 3
  • MIRN766 3
  • MIR766 2

External Ids for MIR766 Gene

Previous HGNC Symbols for MIR766 Gene

  • MIRN766

Previous GeneCards Identifiers for MIR766 Gene

  • GC0XM118665
  • GC0XM118780

Summaries for MIR766 Gene

Entrez Gene Summary for MIR766 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR766 Gene

MIR766 (MicroRNA 766) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR766 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR766 Gene

Genomics for MIR766 Gene

GeneHancer (GH) Regulatory Elements for MIR766 Gene

Promoters and enhancers for MIR766 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119646 Enhancer 1.2 Ensembl ENCODE dbSUPER 500.7 -0.8 -834 3 SP1 EP300 ZIC2 JUND RELA MEF2C RCOR1 RAD21 TRIM22 OSR2 MIR766 CXorf56 RF00017-8653 SEPTIN6
GH0XJ119674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.9 -37.9 -37863 20.2 FOXK2 HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G SP1 SEPTIN6 NKAPP1 UPF3B NKRF MIR766 CXorf56 LINC01402 EEF1A1P30 SLC25A5-AS1 CUL4B
GH0XJ119753 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.8 -110.6 -110562 7.6 CTCF SIN3A USF1 SP1 EP300 ZIC2 KDM6A ZNF423 ZBTB26 RFX1 SOWAHD RNF113A NDUFA1 MIR766 UPF3B SEPTIN6 ZBTB33 HSALNG0139786 piR-50406
GH0XJ119666 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 -20.4 -20446 2.2 USF1 ZIC2 TRIM28 ZNF341 ZBTB17 ZNF263 NBN ZFHX2 ZNF335 IKZF3 MIR766 RF00017-8654 SEPTIN6
GH0XJ119669 Enhancer 1 Ensembl ENCODE dbSUPER 14.1 -22.9 -22875 1.4 TRIM28 TEAD1 MXI1 OSR2 NR2F2 FOXA2 SAP130 MXD4 USF1 FOXP2 MIR766 RF00017-8654 SEPTIN6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR766 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR766 Gene

Genomic Locations for MIR766 Gene
chrX:119,646,738-119,646,848
(GRCh38/hg38)
Size:
111 bases
Orientation:
Minus strand
chrX:118,780,701-118,780,811
(GRCh37/hg19)
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR766 Gene

Genes around MIR766 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR766 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR766 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR766 Gene

Proteins for MIR766 Gene

Post-translational modifications for MIR766 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR766 Gene

Domains & Families for MIR766 Gene

Gene Families for MIR766 Gene

HGNC:
genes like me logo Genes that share domains with MIR766: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR766 Gene

Function for MIR766 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR766 Gene

Localization for MIR766 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR766 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR766: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR766 Gene

Pathways & Interactions for MIR766 Gene

PathCards logo

SuperPathways for MIR766 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031393 negative regulation of prostaglandin biosynthetic process IDA 30769772
GO:0035195 gene silencing by miRNA IDA 30769772
GO:0045409 negative regulation of interleukin-6 biosynthetic process IDA 30769772
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 30769772
GO:0050724 negative regulation of interleukin-1 beta biosynthetic process IDA 30769772
genes like me logo Genes that share ontologies with MIR766: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR766 Gene

Drugs & Compounds for MIR766 Gene

No Compound Related Data Available

Transcripts for MIR766 Gene

mRNA/cDNA for MIR766 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR766 Gene

No ASD Table

Relevant External Links for MIR766 Gene

GeneLoc Exon Structure for
MIR766

Expression for MIR766 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR766 Gene

genes like me logo Genes that share expression patterns with MIR766: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR766 Gene

Orthologs for MIR766 Gene

Evolution for MIR766 Gene

ENSEMBL:
Gene Tree for MIR766 (if available)
TreeFam:
Gene Tree for MIR766 (if available)

No data available for Orthologs for MIR766 Gene

Paralogs for MIR766 Gene

No data available for Paralogs for MIR766 Gene

Variants for MIR766 Gene

Additional dbSNP identifiers (rs#s) for MIR766 Gene

Additional Variant Information for MIR766 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR766

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR766 Gene

Disorders for MIR766 Gene

Additional Disease Information for MIR766

No disorders were found for MIR766 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR766 Gene

Publications for MIR766 Gene

  1. Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells. (PMID: 30664179) Zhao M … Liu H (Oncology reports 2019) 3 54
  2. MicroRNA‑766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway. (PMID: 30387841) Zhao J … Zhang X (International journal of oncology 2019) 3 54
  3. MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling. (PMID: 30769772) Hayakawa K … Sekigawa I (International journal of molecular sciences 2019) 3 54
  4. MicroRNA-766 promotes cancer progression by targeting NR3C2 in hepatocellular carcinoma. (PMID: 30130435) Yang C … Zhuang L (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 54
  5. Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma. (PMID: 31330234) Liu L … Yang L (Gene 2019) 3 54

Products for MIR766 Gene

Sources for MIR766 Gene