microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR765 Gene

Subcategory (RNA class) for MIR765 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR765 Gene

  • MicroRNA 765 2 3 5
  • Hsa-MiR-765 166 177
  • MIMAT0003945 51
  • Hsa-Mir-765 3
  • MI0005116 51
  • Mir-765 3
  • MIRN765 3
  • RF01027 172
  • MIR765 2

External Ids for MIR765 Gene

Previous HGNC Symbols for MIR765 Gene

  • MIRN765

Previous GeneCards Identifiers for MIR765 Gene

  • GC01M155173

Summaries for MIR765 Gene

Entrez Gene Summary for MIR765 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR765 Gene

MIR765 (MicroRNA 765) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR765 include Anxiety.

Rfam classification for MIR765 Gene

Additional gene information for MIR765 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR765 Gene

Genomics for MIR765 Gene

GeneHancer (GH) Regulatory Elements for MIR765 Gene

Promoters and enhancers for MIR765 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156804 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +131.1 131144 4.2 ZIC2 POLR2A ZBTB11 ZNF341 OSR2 NR2F2 WT1 ZNF316 ZBTB17 ZNF263 HDGF MRPL24 INSRR PEAR1 LRRC71 RRNAD1 ISG20L2 MIR765 ARHGEF11 ENSG00000223356
GH01J156890 Enhancer 1.1 Ensembl ENCODE 11.4 +46.1 46109 1 CTCF USF1 RBAK ZNF639 ZBTB10 REST KLF7 TOE1 RAD21 CTBP1 LRRC71 INSRR NTRK1 MIR765 ARHGEF11 ENSG00000223356 MF281431 PEAR1
GH01J156801 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +134.5 134523 1.1 JUND REST POLR2A MXI1 CTCF SMC3 RBM22 EZH2 FOXP2 ZNF654 HDGF MRPL24 INSRR PEAR1 LRRC71 PRCC ISG20L2 RRNAD1 ENSG00000223356 MIR765
GH01J156963 Promoter/Enhancer 0.9 Ensembl ENCODE 11.6 -27.3 -27302 1.1 TOE1 ZBTB17 MYNN GABPA SPI1 RCOR1 ELF1 MITF USF2 KDM1A ARHGEF11 LRRC71 PEAR1 MIR765 lnc-INSRR-2
GH01J156853 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 10 +83.9 83943 1.4 NRF1 TCF7 TBX3 MXI1 FOXA2 WT1 NFIC SAP130 ZFHX2 FOXP1 PEAR1 LRRC71 ENSG00000223356 HDGF MRPL24 MIR765 ARHGEF11 PRCC C1orf61 MIR9-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR765 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR765 Gene

Genomic Locations for MIR765 Gene
chr1:156,936,131-156,936,244
(GRCh38/hg38)
Size:
114 bases
Orientation:
Minus strand
chr1:156,905,923-156,906,036
(GRCh37/hg19)
Size:
114 bases
Orientation:
Minus strand

Genomic View for MIR765 Gene

Genes around MIR765 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR765 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR765 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR765 Gene

Proteins for MIR765 Gene

Post-translational modifications for MIR765 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR765 Gene

Domains & Families for MIR765 Gene

Gene Families for MIR765 Gene

HGNC:
genes like me logo Genes that share domains with MIR765: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR765 Gene

Function for MIR765 Gene

Phenotypes From GWAS Catalog for MIR765 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR765 Gene

Localization for MIR765 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR765 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR765 Gene

Pathways & Interactions for MIR765 Gene

PathCards logo

SuperPathways for MIR765 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR765 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR765 Gene

Drugs & Compounds for MIR765 Gene

No Compound Related Data Available

Transcripts for MIR765 Gene

mRNA/cDNA for MIR765 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR765 Gene

No ASD Table

Relevant External Links for MIR765 Gene

GeneLoc Exon Structure for
MIR765

Expression for MIR765 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR765 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR765

genes like me logo Genes that share expression patterns with MIR765: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR765 Gene

Orthologs for MIR765 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR765 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-765 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR765 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR765 Gene

ENSEMBL:
Gene Tree for MIR765 (if available)
TreeFam:
Gene Tree for MIR765 (if available)

Paralogs for MIR765 Gene

No data available for Paralogs for MIR765 Gene

Variants for MIR765 Gene

Additional dbSNP identifiers (rs#s) for MIR765 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR765 Gene

Variant ID Type Subtype PubMed ID
esv3890682 CNV loss 25118596
nsv831659 CNV loss 17160897

Additional Variant Information for MIR765 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR765

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR765 Gene

Disorders for MIR765 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR765 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR765

genes like me logo Genes that share disorders with MIR765: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR765 Gene

Publications for MIR765 Gene

  1. Regulation of Cancer Stem Cell Self-Renewal by HOXB9 Antagonizes Endoplasmic Reticulum Stress-Induced Melanoma Cell Apoptosis via the miR-765-FOXA2 Axis. (PMID: 29408459) Lin J … Han C (The Journal of investigative dermatology 2018) 3 54
  2. LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2. (PMID: 29315846) Ding J … Yang S (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018) 3 54
  3. Epigenetic regulation of SMARCB1 By miR-206, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma. A miRNA study of 223 soft tissue sarcomas. (PMID: 27223121) Sápi Z … Fletcher CD (Genes, chromosomes & cancer 2016) 3 54
  4. Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma. (PMID: 27062697) Xie BH … Li HP (Cancer biomarkers : section A of Disease markers 2016) 3 54
  5. MicroRNA-765 influences arterial stiffness through modulating apelin expression. (PMID: 25882991) Liao YC … Juo SH (Molecular and cellular endocrinology 2015) 3 54

Products for MIR765 Gene

Sources for MIR765 Gene