microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR758 Gene

Subcategory (RNA class) for MIR758 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR758 Gene

  • MicroRNA 758 2 3 5
  • Hsa-Mir-758 2 3
  • MIR758 2 5
  • Hsa-Mir-154-P26 178
  • Hsa-MiR-758-3p 173
  • MIMAT0003879 50
  • MIMAT0022929 50
  • MI0003757 50
  • MIRN758 3
  • Mir-758 3

External Ids for MIR758 Gene

Previous HGNC Symbols for MIR758 Gene

  • MIRN758

Previous GeneCards Identifiers for MIR758 Gene

  • GC14P100816
  • GC14P100908
  • GC14P101494
  • GC14P101708
  • GC14P101749
  • GC14P101807
  • GC14P101947
  • GC14P102138
  • GC14P101237
  • GC14P101805
  • GC14P103646
  • GC14P103866
  • GC14P104142
  • GC14P104484
  • GC14P102099
  • GC14P102334
  • GC14P102506
  • GC14P102683
  • GC14P102854
  • GC14P103028
  • GC14P103224
  • GC14P103463

Summaries for MIR758 Gene

Entrez Gene Summary for MIR758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR758 Gene

MIR758 (MicroRNA 758) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR758 include Spleen Angiosarcoma.

Additional gene information for MIR758 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR758 Gene

Genomics for MIR758 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR758 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101091 Enhancer 0.3 Ensembl 10.4 +65.3 65281 1 JUN MIR377 MIR154 MIR496 MIR134 MIR323B MIR485 MIR487A MIR329-1 MIR329-2 MIR323A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR758 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR758 Gene

Genomic Locations for MIR758 Gene
chr14:101,026,020-101,026,107
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand
chr14:101,492,357-101,492,444
(GRCh37/hg19)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR758 Gene

Genes around MIR758 on UCSC Golden Path with GeneCards custom track
MIR758 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR758 Gene

Proteins for MIR758 Gene

Post-translational modifications for MIR758 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR758 Gene

Domains & Families for MIR758 Gene

Gene Families for MIR758 Gene

genes like me logo Genes that share domains with MIR758: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR758 Gene

Function for MIR758 Gene

Gene Ontology (GO) - Molecular Function for MIR758 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21885853
genes like me logo Genes that share ontologies with MIR758: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR758 Gene

Localization for MIR758 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR758 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR758 Gene

Pathways & Interactions for MIR758 Gene

PathCards logo

SuperPathways for MIR758 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR758 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 21885853
GO:0071404 cellular response to low-density lipoprotein particle stimulus IDA 21885853
GO:0090370 negative regulation of cholesterol efflux IDA 21885853
genes like me logo Genes that share ontologies with MIR758: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR758 Gene

Drugs & Compounds for MIR758 Gene

No Compound Related Data Available

Transcripts for MIR758 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR758 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DEC1_9606 precursor_RNA 88 5

HGNC: 33133,

RefSeq: NR_030406,

Ensembl: ENST00000390227 (view in UCSC) ,

miRBase: MI0003757,

ENA: LM609618.1:1..88:precursor_RNA,

URS000024B619_9606 miRNA 22 5

RefSeq: NR_030406,

miRBase: MIMAT0003879,

MirGeneDB: Hsa-Mir-154-P26_3p,

TarBase: hsa-miR-758-3p,

ENA: LM380024.1:1..22:ncRNA, LM609618.1:52..73:ncRNA,

URS0000457089_9606 miRNA 22 3

RefSeq: NR_030406,

miRBase: MIMAT0022929,

ENA: LM383088.1:1..22:ncRNA, LM609618.1:15..36:ncRNA,

URS0000EFD757_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-154-P26,

URS00007E3FDA_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-154-P26_5p,

MIR758 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR758 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR758 Gene

No ASD Table

Relevant External Links for MIR758 Gene

GeneLoc Exon Structure for
MIR758

Expression for MIR758 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR758 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR758

genes like me logo Genes that share expression patterns with MIR758: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR758 Gene

Orthologs for MIR758 Gene

Evolution for MIR758 Gene

ENSEMBL:
Gene Tree for MIR758 (if available)
TreeFam:
Gene Tree for MIR758 (if available)

No data available for Orthologs for MIR758 Gene

Paralogs for MIR758 Gene

No data available for Paralogs for MIR758 Gene

Variants for MIR758 Gene

Additional dbSNP identifiers (rs#s) for MIR758 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR758 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR758

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR758 Gene

Disorders for MIR758 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR758 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spleen angiosarcoma
  • angiosarcoma of spleen
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR758

genes like me logo Genes that share disorders with MIR758: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR758 Gene

Publications for MIR758 Gene

  1. Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB. (PMID: 30446524) Zhou GH … Gu WG (Bioscience reports 2019) 3
  2. MicroRNA‑758 inhibits tumorous behavior in tongue squamous cell carcinoma by directly targeting metadherin. (PMID: 30628702) Zhang Y … Zhao F (Molecular medicine reports 2019) 3
  3. MiR-758-3p regulates papillary thyroid cancer cell proliferation and migration by targeting TAB1. (PMID: 30940308) Chen J … Chen B (Die Pharmazie 2019) 3
  4. Glucagon-like peptide-1 contributes to increases ABCA1 expression by downregulating miR-758 to regulate cholesterol homeostasis. (PMID: 29453982) Yao Y … Xu Y (Biochemical and biophysical research communications 2018) 3
  5. Identification of miR-758-3p as Potential Modulator of CBX5 Expression in Gastric Cancer. (PMID: 30486755) Guo J … Zhou Y (Technology in cancer research & treatment 2018) 3

Products for MIR758 Gene

Sources for MIR758 Gene