microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR744 Gene

Subcategory (RNA class) for MIR744 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR744 Gene

  • MicroRNA 744 2 3 5
  • Hsa-MiR-744-5p 168 179
  • Hsa-MiR-744-3p 168 179
  • MIMAT0004945 53
  • MIMAT0004946 53
  • Hsa-Mir-744 3
  • MI0005559 53
  • Mir-744 3
  • MIRN744 3
  • RF00936 174
  • MIR744 2

External Ids for MIR744 Gene

Previous HGNC Symbols for MIR744 Gene

  • MIRN744

Previous GeneCards Identifiers for MIR744 Gene

  • GC17P011927

Summaries for MIR744 Gene

Entrez Gene Summary for MIR744 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR744 Gene

MIR744 (MicroRNA 744) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR744 Gene

Additional gene information for MIR744 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR744 Gene

Genomics for MIR744 Gene

GeneHancer (GH) Regulatory Elements for MIR744 Gene

Promoters and enhancers for MIR744 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J012023 Enhancer 0.6 ENCODE 11 -57.3 -57296 2.4 FOSL2 CEBPB JUN JUND SP1 SCRT2 ZSCAN5C EP300 FOXA2 STAT3 MIR744 ENSG00000241185 MAP2K4 lnc-ZNF18-3 RNU11-2P
GH17J012046 Enhancer 0.4 ENCODE 11.1 -35.1 -35078 1.4 HLF MAFK SOX6 MAP2K4 MIR744 RNU11-2P HSALNG0114606
GH17J012105 Enhancer 0.3 Ensembl 11.7 +23.6 23603 1.4 HLF PRDM6 MIR744 MAP2K4 LOC103156999
GH17J012104 Enhancer 0.2 Ensembl 11.7 +22.2 22204 0.2 MIR744 MAP2K4 LOC103156999
GH17J012050 Enhancer 0.2 ENCODE 11.6 -31.1 -31056 1.1 MIR744 MAP2K4 RNU11-2P HSALNG0114606
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR744 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR744 Gene

Genomic Locations for MIR744 Gene
chr17:12,081,897-12,081,996
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr17:11,985,216-11,985,313
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR744 Gene

Genes around MIR744 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR744 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR744 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR744 Gene

Proteins for MIR744 Gene

Post-translational modifications for MIR744 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR744 Gene

Domains & Families for MIR744 Gene

Gene Families for MIR744 Gene

HGNC:
genes like me logo Genes that share domains with MIR744: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR744 Gene

Function for MIR744 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR744 Gene

Localization for MIR744 Gene

Gene Ontology (GO) - Cellular Components for MIR744 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR744: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR744 Gene

Pathways & Interactions for MIR744 Gene

PathCards logo

SuperPathways for MIR744 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR744 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR744: view

No data available for Pathways by source and SIGNOR curated interactions for MIR744 Gene

Drugs & Compounds for MIR744 Gene

No Compound Related Data Available

Transcripts for MIR744 Gene

mRNA/cDNA for MIR744 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) TarBase transcripts :
(5) ENA transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR744 Gene

No ASD Table

Relevant External Links for MIR744 Gene

GeneLoc Exon Structure for
MIR744
ECgene alternative splicing isoforms for
MIR744

Expression for MIR744 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR744 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR744 Gene:

MIR744
genes like me logo Genes that share expression patterns with MIR744: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR744 Gene

Orthologs for MIR744 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR744 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-744 33
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir744 33
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-744 33
  • 92 (a)
OneToOne
Species where no ortholog for MIR744 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR744 Gene

ENSEMBL:
Gene Tree for MIR744 (if available)
TreeFam:
Gene Tree for MIR744 (if available)

Paralogs for MIR744 Gene

No data available for Paralogs for MIR744 Gene

Variants for MIR744 Gene

Sequence variations from dbSNP and Humsavar for MIR744 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1002829757 -- 12,079,953(+) T/C upstream_transcript_variant
rs1003321895 -- 12,081,655(+) C/A upstream_transcript_variant
rs1005543001 -- 12,080,723(+) A/G upstream_transcript_variant
rs1005554757 -- 12,080,973(+) A/G upstream_transcript_variant
rs1007003931 -- 12,082,314(+) A/G downstream_transcript_variant

Additional Variant Information for MIR744 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR744

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR744 Gene

Disorders for MIR744 Gene

Additional Disease Information for MIR744

No disorders were found for MIR744 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR744 Gene

Publications for MIR744 Gene

  1. Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744. (PMID: 23695020) Vislovukh A … Groisman I (British journal of cancer 2013) 2 3 56
  2. Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744. (PMID: 21991303) Martin J … Fraser DJ (PloS one 2011) 2 3 56
  3. MicroRNA‑744 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1. (PMID: 30628685) Liu H … Meng X (Molecular medicine reports 2019) 3 56
  4. Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure. (PMID: 30392569) Wang L … Liu Z (The Kaohsiung journal of medical sciences 2018) 3 56
  5. MicroRNA‑744 inhibits migration and invasion of hepatocellular carcinoma cells by targeting SOX12. (PMID: 30542724) Zhang W … Liu Y (Oncology reports 2018) 3 56

Products for MIR744 Gene

Sources for MIR744 Gene