microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR718 Gene

Subcategory (RNA class) for MIR718 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR718 Gene

  • MicroRNA 718 2 3 5
  • Hsa-Mir-718 2 3
  • MIR718 2 5
  • MIMAT0012735 50
  • MI0012489 50

External Ids for MIR718 Gene

Previous GeneCards Identifiers for MIR718 Gene

  • GC00U930648
  • GC0XM153286

Summaries for MIR718 Gene

Entrez Gene Summary for MIR718 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR718 Gene

MIR718 (MicroRNA 718) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR718 include Spongiotic Dermatitis and Aortic Valve Disease 1. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Signaling by GPCR.

Additional gene information for MIR718 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR718 Gene

Genomics for MIR718 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR718 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154017 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.0 29 4.3 HNRNPL PRDM10 ZNF692 JUND LARP7 PRDM1 ZIC2 RBFOX2 PATZ1 POLR2A IRAK1 MIR718 lnc-TMEM187-3 TMEM187 lnc-MECP2-1 MECP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR718 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR718 Gene

Genomic Locations for MIR718 Gene
chrX:154,019,920-154,019,989
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chrX:153,285,371-153,285,440
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR718 Gene

Genes around MIR718 on UCSC Golden Path with GeneCards custom track
MIR718 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR718 Gene

Proteins for MIR718 Gene

Post-translational modifications for MIR718 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR718 Gene

Domains & Families for MIR718 Gene

Gene Families for MIR718 Gene

HGNC:
genes like me logo Genes that share domains with MIR718: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR718 Gene

Function for MIR718 Gene

Phenotypes From GWAS Catalog for MIR718 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR718 Gene

Localization for MIR718 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR718 Gene

Pathways & Interactions for MIR718 Gene

PathCards logo

SuperPathways for MIR718 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 p75 NTR receptor-mediated signalling
4 IL-1 signaling pathway
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with MIR718: view

Gene Ontology (GO) - Biological Process for MIR718 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR718 Gene

Drugs & Compounds for MIR718 Gene

No Compound Related Data Available

Transcripts for MIR718 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR718 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EB45_9606 precursor_RNA 70 4

HGNC: 37317,

RefSeq: NR_031757,

Ensembl: ENST00000390190 (view in UCSC) ,

miRBase: MI0012489,

URS000075B1FD_9606 miRNA 21 2

RefSeq: NR_031757,

miRBase: MIMAT0012735,

MIR718 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR718 Gene

No ASD Table

Relevant External Links for MIR718 Gene

GeneLoc Exon Structure for
MIR718

No data available for mRNA/cDNA for MIR718 Gene

Expression for MIR718 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR718 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR718

genes like me logo Genes that share expression patterns with MIR718: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR718 Gene

Orthologs for MIR718 Gene

Evolution for MIR718 Gene

ENSEMBL:
Gene Tree for MIR718 (if available)
TreeFam:
Gene Tree for MIR718 (if available)

No data available for Orthologs for MIR718 Gene

Paralogs for MIR718 Gene

No data available for Paralogs for MIR718 Gene

Variants for MIR718 Gene

Additional dbSNP identifiers (rs#s) for MIR718 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR718 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1133775 CNV deletion 24896259

Additional Variant Information for MIR718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR718 Gene

Disorders for MIR718 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR718 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spongiotic dermatitis
aortic valve disease 1
  • aovd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR718

genes like me logo Genes that share disorders with MIR718: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR718 Gene

Publications for MIR718 Gene

  1. MicroRNA‑718 serves a tumor‑suppressive role in non‑small cell lung cancer by directly targeting CCNB1. (PMID: 31746372) Wang S … Wang Q (International journal of molecular medicine 2020) 3
  2. LncRNA FBXL19-AS1 promotes breast cancer cells proliferation and invasion via acting as a molecular sponge to miR-718. (PMID: 30886065) Ding Z … Cai H (Bioscience reports 2019) 3
  3. MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. (PMID: 31251699) Zhong Y … Zhang D (Physiological genomics 2019) 3
  4. miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1. (PMID: 30166214) Wang X … Qi M (Pathology, research and practice 2018) 3
  5. High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer. (PMID: 30131483) Liu S … Sun Q (Medical science monitor : international medical journal of experimental and clinical research 2018) 3

Products for MIR718 Gene

Sources for MIR718 Gene