microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR7108 Gene

Subcategory (RNA class) for MIR7108 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR7108 Gene

  • MicroRNA 7108 2 3 5
  • Hsa-Mir-7108 2 3
  • MIR7108 2 5
  • MicroRNA Mir-7108 3
  • MIMAT0028114 50
  • MIMAT0028113 50
  • MI0022959 50

External Ids for MIR7108 Gene

Previous GeneCards Identifiers for MIR7108 Gene

  • GC19U901843

Summaries for MIR7108 Gene

Entrez Gene Summary for MIR7108 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7108 Gene

MIR7108 (MicroRNA 7108) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR7108 include Epilepsy, Progressive Myoclonic, 9 and Lipodystrophy, Partial, Acquired. Among its related pathways are Gastric Cancer Network 2 and Apoptosis and survival Caspase cascade.

Additional gene information for MIR7108 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR7108 Gene

Genomics for MIR7108 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR7108 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002454 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -21.1 -21087 3.5 GATAD2A PRDM10 ZNF629 ZNF512 SIX5 IKZF1 LARP7 ZNF143 RBFOX2 PKNOX1 LMNB2 lnc-TIMM13-2 TMPRSS9 TIMM13 ENSG00000267214 MIR7108 lnc-GADD45B-1 ENSG00000267412
GH19J002446 Enhancer 0.7 Ensembl ENCODE 0.4 -11.8 -11801 2.8 PKNOX1 SP2 CTCF RUNX3 POLR2A SPI1 EBF1 SMARCA4 BHLHE40 TMPRSS9 TIMM13 LMNB2 MIR7108 lnc-TIMM13-2 lnc-GADD45B-1 ENSG00000267412
GH19J002452 Enhancer 0.5 ENCODE 0.4 -18.0 -18030 0.6 ZNF692 ZNF600 ZNF341 ZNF18 GLIS1 KLF1 POLR2A CREM TMPRSS9 TIMM13 REXO1 LMNB2 lnc-TIMM13-2 MIR7108 lnc-GADD45B-1 ENSG00000267412
GH19J002449 Enhancer 0.3 Ensembl 0.4 -14.1 -14101 0.2 ZNF664 ZNF121 TIMM13 LMNB2 lnc-TIMM13-2 MIR7108 lnc-GADD45B-1 ENSG00000267412
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR7108 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR7108 Gene

Genomic Locations for MIR7108 Gene
chr19:2,434,914-2,435,000
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR7108 Gene

Genes around MIR7108 on UCSC Golden Path with GeneCards custom track
MIR7108 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR7108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7108 Gene

Proteins for MIR7108 Gene

Post-translational modifications for MIR7108 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7108 Gene

Domains & Families for MIR7108 Gene

Gene Families for MIR7108 Gene

HGNC:
genes like me logo Genes that share domains with MIR7108: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR7108 Gene

Function for MIR7108 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7108 Gene

Localization for MIR7108 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR7108 Gene

Pathways & Interactions for MIR7108 Gene

genes like me logo Genes that share pathways with MIR7108: view

Pathways by source for MIR7108 Gene

Gene Ontology (GO) - Biological Process for MIR7108 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR7108 Gene

Drugs & Compounds for MIR7108 Gene

No Compound Related Data Available

Transcripts for MIR7108 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR7108 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B9C6_9606 precursor_RNA 87 4

HGNC: 49998,

RefSeq: NR_106958,

Ensembl: ENST00000614319 (view in UCSC) ,

miRBase: MI0022959,

URS000075A4B1_9606 miRNA 21 2

RefSeq: NR_106958,

miRBase: MIMAT0028113,

URS000075BD2F_9606 miRNA 20 2

RefSeq: NR_106958,

miRBase: MIMAT0028114,

MIR7108 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7108 Gene

No ASD Table

Relevant External Links for MIR7108 Gene

GeneLoc Exon Structure for
MIR7108

No data available for mRNA/cDNA for MIR7108 Gene

Expression for MIR7108 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7108 Gene

Orthologs for MIR7108 Gene

Evolution for MIR7108 Gene

ENSEMBL:
Gene Tree for MIR7108 (if available)
TreeFam:
Gene Tree for MIR7108 (if available)

No data available for Orthologs for MIR7108 Gene

Paralogs for MIR7108 Gene

No data available for Paralogs for MIR7108 Gene

Variants for MIR7108 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR7108 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs375918278 Likely Benign: Epilepsy, progressive myoclonic, 9; Lipodystrophy, partial, acquired, susceptibility to 2,434,993(-) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs766316644 Likely Benign: Epilepsy, progressive myoclonic, 9; Lipodystrophy, partial, acquired, susceptibility to 2,434,921(-) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR7108 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR7108 Gene

Variant ID Type Subtype PubMed ID
nsv1064930 CNV gain 25217958
nsv1160562 CNV deletion 26073780
nsv953944 CNV deletion 24416366

Additional Variant Information for MIR7108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR7108 Gene

Disorders for MIR7108 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR7108 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR7108

genes like me logo Genes that share disorders with MIR7108: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR7108 Gene

Publications for MIR7108 Gene

  1. Discovery of hundreds of mirtrons in mouse and human small RNA data. (PMID: 22955976) Ladewig E … Lai EC (Genome research 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR7108 Gene

Sources for MIR7108 Gene