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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR7107 (MicroRNA 7107) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J121443 | Enhancer | 0.9 | Ensembl ENCODE | 600.7 | +1.2 | 1198 | 0.7 | CTCF IKZF1 ZNF692 ZNF143 ZIC2 REST RAD21 IRF2 TRIM22 ZNF600 | MIR7107 KDM2B FJ601684-089 RNF34 lnc-CAMKK2-1 | |
GH12J121444 | Enhancer | 0.7 | ENCODE | 600.7 | +0.6 | 649 | 0.2 | CTCF ZNF692 ZNF143 REST IRF2 TRIM22 ZNF600 ZBTB48 MAX ZFHX2 | MIR7107 FJ601684-089 RNF34 KDM2B lnc-CAMKK2-1 | |
GH12J121445 | Enhancer | 0.3 | ENCODE | 600.7 | -0.1 | -81 | 0.2 | ZNF189 | MIR7107 HE856031-001 RNF34 KDM2B lnc-CAMKK2-1 | |
GH12J121449 | Enhancer | 0.7 | FANTOM5 ENCODE | 0.4 | -7.5 | -7504 | 3.9 | ZBTB33 IKZF1 FOXA1 ESRRA MEF2D GATA3 SPI1 MAZ SMARCE1 ZNF121 | ENSG00000258435 MIR7107 HE856031-001 RNF34 KDM2B lnc-CAMKK2-1 | |
GH12J121455 | Enhancer | 0.4 | ENCODE | 0.4 | -12.5 | -12463 | 1.8 | ZSCAN4 ZNF248 ZFP3 | ENSG00000258435 TMEM120B KDM2B HE856031-001 MIR7107 RNF34 lnc-CAMKK2-1 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075CB30_9606 | precursor_RNA | 80 | 4 |
HGNC: 50006, RefSeq: NR_106957, Ensembl: ENST00000611489 (view in UCSC) , miRBase: MI0022958, |
URS0000759FB2_9606 | miRNA | 27 | 2 |
RefSeq: NR_106957, miRBase: MIMAT0028112, |
URS000075D394_9606 | miRNA | 22 | 2 |
RefSeq: NR_106957, miRBase: MIMAT0028111, |
No disorders were found for MIR7107 Gene.