microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR708 Gene

Subcategory (RNA class) for MIR708 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR708 Gene

  • MicroRNA 708 2 3 5
  • Hsa-MiR-708-3p 166 177
  • Hsa-MiR-708-5p 166 177
  • MIMAT0004926 51
  • MIMAT0004927 51
  • Hsa-Mir-708 3
  • MI0005543 51
  • MIRN708 3
  • RF00917 172
  • MIR708 2

External Ids for MIR708 Gene

Previous HGNC Symbols for MIR708 Gene

  • MIRN708

Previous GeneCards Identifiers for MIR708 Gene

  • GC11M078793
  • GC11M079113

Summaries for MIR708 Gene

Entrez Gene Summary for MIR708 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR708 Gene

MIR708 (MicroRNA 708) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR708 include Leukemia, Acute Lymphoblastic and Lymph Node Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR708 Gene

Additional gene information for MIR708 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR708 Gene

Genomics for MIR708 Gene

GeneHancer (GH) Regulatory Elements for MIR708 Gene

Promoters and enhancers for MIR708 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J079400 Enhancer 0.5 Ensembl 500.7 +1.5 1546 1.1 CTCF TEAD4 RAD21 TRIM22 SMC3 MYC ZNF843 SMARCA4 ZNF143 MIR708 RF00655-001 TENM4 lnc-TENM4-3 lnc-NARS2-2
GH11J079401 Enhancer 0.3 Ensembl 500.7 +0.8 808 0.2 CTCF PKNOX1 MIR708 RF00655-001 lnc-TENM4-3 TENM4 lnc-NARS2-2
GH11J079402 Enhancer 0.3 Ensembl 500.7 -0.6 -592 0.2 EGR2 MIR708 RF00655-001 MIR5579 lnc-TENM4-3 TENM4
GH11J079375 Enhancer 0.6 Ensembl ENCODE 11.5 +26.4 26408 3.4 SIN3A CHD7 SP1 ZNF24 TENM4 MIR708 RF00655-001 lnc-NARS2-2 lnc-TENM4-3
GH11J079371 Enhancer 0.5 Ensembl ENCODE 10.9 +30.6 30608 1 CTCF RAD21 TENM4 MIR708 lnc-NARS2-2 RF00655-001 lnc-TENM4-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR708 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR708 Gene

Genomic Locations for MIR708 Gene
chr11:79,402,022-79,402,109
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr11:79,113,066-79,113,153
(GRCh37/hg19)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR708 Gene

Genes around MIR708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR708 Gene

Proteins for MIR708 Gene

Post-translational modifications for MIR708 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR708 Gene

Domains & Families for MIR708 Gene

Gene Families for MIR708 Gene

HGNC:
genes like me logo Genes that share domains with MIR708: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR708 Gene

Function for MIR708 Gene

Phenotypes From GWAS Catalog for MIR708 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR708 Gene

Localization for MIR708 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR708 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR708 Gene

Pathways & Interactions for MIR708 Gene

genes like me logo Genes that share pathways with MIR708: view

Pathways by source for MIR708 Gene

1 BioSystems pathway for MIR708 Gene
;

Gene Ontology (GO) - Biological Process for MIR708 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR708 Gene

Drugs & Compounds for MIR708 Gene

No Compound Related Data Available

Transcripts for MIR708 Gene

mRNA/cDNA for MIR708 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR708 Gene

No ASD Table

Relevant External Links for MIR708 Gene

GeneLoc Exon Structure for
MIR708

Expression for MIR708 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR708 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR708

genes like me logo Genes that share expression patterns with MIR708: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR708 Gene

Orthologs for MIR708 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR708 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-708 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-708 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-708 31
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir708 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
OneToOne
Species where no ortholog for MIR708 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR708 Gene

ENSEMBL:
Gene Tree for MIR708 (if available)
TreeFam:
Gene Tree for MIR708 (if available)

Paralogs for MIR708 Gene

No data available for Paralogs for MIR708 Gene

Variants for MIR708 Gene

Additional dbSNP identifiers (rs#s) for MIR708 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR708 Gene

Variant ID Type Subtype PubMed ID
nsv832214 CNV gain 17160897
nsv832216 CNV gain 17160897

Additional Variant Information for MIR708 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR708

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR708 Gene

Disorders for MIR708 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR708 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic
  • all
lymph node cancer
  • lymph node neoplasm
pleuropulmonary blastoma
  • ppb
pulmonary blastoma
  • blastoma of lung
pleural disease
  • disorder of pleura
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR708

genes like me logo Genes that share disorders with MIR708: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR708 Gene

Publications for MIR708 Gene

  1. Development of Response Classifier for Vascular Endothelial Growth Factor Receptor (VEGFR)-Tyrosine Kinase Inhibitor (TKI) in Metastatic Renal Cell Carcinoma. (PMID: 28963640) Go H … Cho YM (Pathology oncology research : POR 2019) 3 54
  2. MicroRNA‑708 inhibits the proliferation and invasion of osteosarcoma cells by directly targeting ZEB1. (PMID: 30864726) He J … Lin Y (Molecular medicine reports 2019) 3 54
  3. MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3. (PMID: 30683474) Huang S … Xiong J (Pathology, research and practice 2019) 3 54
  4. MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor. (PMID: 30470587) Roberto GM … Brassesco MS (Cancer genetics 2019) 3 54
  5. MicroRNA-708 activation by glucocorticoid receptor agonists regulate breast cancer tumorigenesis and metastasis via downregulation of NF-κB signaling. (PMID: 30726934) Senthil Kumar KJ … Wang SY (Carcinogenesis 2019) 3 54

Products for MIR708 Gene

Sources for MIR708 Gene