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Aliases for MIR708 Gene

Subcategory (RNA class) for MIR708 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR708 Gene

  • MicroRNA 708 2 3 5
  • Hsa-Mir-708 3
  • MIRN708 3

External Ids for MIR708 Gene

Previous HGNC Symbols for MIR708 Gene

  • MIRN708

Previous GeneCards Identifiers for MIR708 Gene

  • GC11M078793
  • GC11M079113

Summaries for MIR708 Gene

Entrez Gene Summary for MIR708 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR708 Gene

MIR708 (MicroRNA 708) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR708 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR708

Additional gene information for MIR708 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR708 Gene

Genomics for MIR708 Gene

GeneHancer (GH) Regulatory Elements for MIR708 Gene

Promoters and enhancers for MIR708 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I079375 Enhancer 0.4 ENCODE 10.6 +25.8 25840 1.3 SP1 ZNF24 MIR708 TENM4 GC11M079348
GH11I079371 Enhancer 0.3 ENCODE 10.9 +30.7 30737 0.2 CTCF MIR708 TENM4 GC11M079348
GH11I079433 Enhancer 0.3 ENCODE 10.8 -32.2 -32151 0.9 BCL6B MIR708 TENM4 MIR5579
GH11I079266 Enhancer 0.3 ENCODE 9 +135.5 135518 0.2 FEZF1 MIR708 ENSG00000254885 GC11M079348 TENM4
GH11I079267 Enhancer 0.3 ENCODE 9 +136.0 136018 0.2 ZFP3 MIR708 ENSG00000254885 GC11M079348 TENM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR708 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR708 Gene

Genomic Locations for MIR708 Gene
chr11:79,402,022-79,402,109
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr11:79,113,066-79,113,153
(GRCh37/hg19)

Genomic View for MIR708 Gene

Genes around MIR708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR708 Gene

ORGUL Member Location for MIR708 Gene

ORGUL Member Location for MIR708 gene

Proteins for MIR708 Gene

Post-translational modifications for MIR708 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR708 Gene

Domains & Families for MIR708 Gene

Gene Families for MIR708 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR708: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR708 Gene

Function for MIR708 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR708 Gene

Localization for MIR708 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR708 Gene

Pathways & Interactions for MIR708 Gene

genes like me logo Genes that share pathways with MIR708: view

Pathways by source for MIR708 Gene

1 BioSystems pathway for MIR708 Gene

Interacting Proteins for MIR708 Gene

Gene Ontology (GO) - Biological Process for MIR708 Gene

None

No data available for SIGNOR curated interactions for MIR708 Gene

Drugs & Compounds for MIR708 Gene

No Compound Related Data Available

Transcripts for MIR708 Gene

fRNAdb Secondary structures for MIR708 Gene

  • hsa-miR-708-3p_MIMAT0004927_Homo_sapiens_miR-708-3p_mature

mRNA/cDNA for MIR708 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR708 Gene

No ASD Table

Relevant External Links for MIR708 Gene

GeneLoc Exon Structure for
MIR708
ECgene alternative splicing isoforms for
MIR708

Expression for MIR708 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR708 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR708 Gene:

MIR708
genes like me logo Genes that share expression patterns with MIR708: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR708 Gene

Orthologs for MIR708 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR708 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-708 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-708 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-708 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir708 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToOne
Species where no ortholog for MIR708 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR708 Gene

ENSEMBL:
Gene Tree for MIR708 (if available)
TreeFam:
Gene Tree for MIR708 (if available)

Paralogs for MIR708 Gene

No data available for Paralogs for MIR708 Gene

Variants for MIR708 Gene

Sequence variations from dbSNP and Humsavar for MIR708 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000994148 -- 79,403,960(-) C/G upstream_transcript_variant
rs1001893947 -- 79,402,061(-) G/A non_coding_transcript_variant
rs1003452257 -- 79,403,345(-) C/T upstream_transcript_variant
rs1003566760 -- 79,403,691(-) A/G upstream_transcript_variant
rs1003695902 -- 79,402,289(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR708 Gene

Variant ID Type Subtype PubMed ID
nsv832214 CNV gain 17160897
nsv832216 CNV gain 17160897

Additional Variant Information for MIR708 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR708

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR708 Gene

Disorders for MIR708 Gene

Additional Disease Information for MIR708

No disorders were found for MIR708 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR708 Gene

Publications for MIR708 Gene

  1. MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer. (PMID: 26678031) Wu X … Luo Z (Oncotarget 2016) 3 58
  2. miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells. (PMID: 26833707) Ma L … Cheng S (Cancer medicine 2016) 3 58
  3. Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer. (PMID: 26870998) Hu L … Deng Y (Oncotarget 2016) 3 58
  4. MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3. (PMID: 26932538) Hao C … Feng Y (Scientific reports 2016) 3 58
  5. MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells. (PMID: 26998837) Dileepan M … Kannan MS (PloS one 2016) 3 58

Products for MIR708 Gene

Sources for MIR708 Gene

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